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在“Elsevier电子期刊”中，命中：56条，耗时：小于0.01 秒

1.Shikonin inhibits gefitinib-resistant non-small cell lung cancer by inhibiting TrxR and activating the EGFR proteasomal degradation pathway

作者：Xia Li¹ ; Xing-Xing Fan¹ ; Ze-Bo Jiang ; Wings TY Loo ; Xiao-Jun Yao ; Elaine Lai-Han Leung ; ^{lhleung@must.edu.mo} ; Louis WC Chow ; ^{wcchow@must.edu.mo} ; Liang Liu ; ^{lliu@must.edu.mo}

关键词：NSCLC ; non-small cell lung cancer cell ; ROS ; reactive oxygen species ; EGFR ; epidermal growth factor receptor ; T790M ; a substitution mutation of threonine with methionine at position 790 of EGFR ; TrxR ; thioredoxin reductases ; MTT ; 3-(4 ; 5-dimetrylthiazol)-2 ; 5-diphenyltetrazolium bromide ; DCFDA ; dichlorofluorescein diacetate ; PBS ; phosphate-buffered saline ; RIPA ; radioimmunoprecipitation assay ; PARP ; poly (ADP-ribosyl) polymerase ; NAC ; N-acetyl-l-cysteine ; MG132 ; proteasomal degradation pathway inh

刊名：Pharmacological Research

出版年：2017

2.Novel hydrophobic cotton fibers adsorbent for the removal of nitrobenzene in aqueous solution

作者：Yanchen Wu ; Houjuan Qi ; Beizhan Li ; Huang Zhanhua ; ^{huangzh1975@163.com" class="auth_mail" title="E-mail the corresponding author} ; Wei Li ; Shouxin Liu ; ^{liushouxin@126.com" class="auth_mail" title="E-mail the corresponding author}

关键词：Hydrophobic ; Cotton fiber ; Nitrobenzene removal ; Adsorption ; Kinetics

刊名：Carbohydrate Polymers

出版年：2017

3.A structure-guided optimization of pyrido[2,3-d]pyrimidin-7-ones as selective inhibitors of EGFR^L858R/T790M mutant with improved pharmacokinetic properties

作者：Lei Yu^a ; ^b ; Minhao Huang^a ; ^b ; Tianfeng Xu^a ; ^b ; Linjiang Tong^d ; Xiao-e Yan^e ; Zhang Zhang^a ; Yong Xu^a ; Caihong Yun^e ; Hua Xie^d ; ^{hxie@simm.ac.cn} ; Ke Ding^a ; ^c ; ^{ding_ke@gibh.ac.cn} ; Xiaoyun Lu^c ; ^{luxy2016@jnu.edu.cn}

关键词：EGFRT790M mutant ; Pyrido[2 ; 3-d]pyrimidin-7-ones ; Pharmacokinetic property ; NSCLC ; Irreversible inhibitor

刊名：European Journal of Medicinal Chemistry

出版年：2017

4.Facile and efficient synthesis and biological evaluation of 4-anilinoquinazoline derivatives as EGFR inhibitors

作者：Zheng Wang^a ; Xue Wu^c ; Li Wang^a ; Jiao Zhang^a ; Jianli Liu^b ; Zhongxing Song^a ; Zhishu Tang^a ; ^{zst6565@126.com" class="auth_mail" title="E-mail the corresponding author}

关键词：4-Anilinoquinazoline ; Synthesis ; MTT assay ; Western blotting analysis

刊名：Bioorganic & Medicinal Chemistry Letters

出版年：2016

5.CA-1H, a novel oxazole bearing analogue of combretastatin A-4, disrupts the tumor vasculatures and inhibits the tumor growth via inhibiting tubulin polymerization

作者：Fuguo Han^a ; Peng Wang^a ; Wei Zhang^b ; Jing Li^a ; Qun Zhang^c ; Xin Qi^a ; ^{qxhin@163.com" class="auth_mail" title="E-mail the corresponding author} ; Ming Liu^a ; ^{lmouc@hotmail.com" class="auth_mail" title="E-mail the corresponding author}

关键词：Tumor ; Vascular disrupting agents ; Combretastatin A-4 ; Oxazole

刊名：Biomedicine & Pharmacotherapy

出版年：2016

6.The Safety and Efficacy of Mineralocorticoid Receptor Antagonists in Patients Who Require Dialysis: A Systematic Review and Meta-analysis

作者：Kevin Quach ; MSc¹ ; Lyubov Lvtvyn ; MSc¹ ; Colin Baigent ; FRCP² ; Joe Bueti ; MD³ ; Amit X. Garg ; MD ; PhD⁴ ; ⁵ ; Carmel Hawley ; MBBS ; MMedSci⁶ ; ⁷ ; Richard Haynes ; DM² ; Braden Manns ; MD ; MSc⁸ ; ⁹ ; Vlado Perkovic ; MD ; PhD¹⁰ ; Christian G. Rabbat ; MD ; MSc¹¹ ; Ron Wald ; MDCM ; MPH¹² ; Michael Walsh ; MD ; PhD¹ ; ¹¹ ; ¹³ ; ^{lastwalsh1975@gmail.com" class="auth_mail" title="E-mail the corresponding author}

关键词：Mineralocorticoid receptor antagonist (MRA) ; spironolactone ; eplerenone ; hemodialysis ; peritoneal dialysis ; cardiovascular death ; all-cause mortality ; hyperkalemia ; blood pressure ; adverse events ; randomized controlled trials ; aldosterone ; end-stage renal disease (ESRD) ; systematic review ; meta-analysis

刊名：American Journal of Kidney Diseases

出版年：2016

7.Novel 4-anilinoquinazoline derivatives featuring an 1-adamantyl moiety as potent EGFR inhibitors with enhanced activity against NSCLC cell lines

作者：Haiqing Yu^a ; ¹ ; Yanxia Li^b ; ¹ ; Yang Ge^a ; Zhendong Song^a ; Changyuan Wang^a ; Shanshan Huang^a ; Yue Jin^a ; Xu Han^a ; Yuhong Zhen^a ; Kexin Liu^a ; ^{kexinliu@dlmedu.edu.cn" class="auth_mail" title="E-mail the corresponding author} ; Youwen Zhou^c ; ^{youwen.zhou@ubc.ca" class="auth_mail" title="E-mail the corresponding author} ; Xiaodong Ma^a ; ^{xiaodong.ma@139.com" class="auth_mail" title="E-mail the corresponding author}

关键词：NSCLC ; EGFR ; T790M ; Quinazoline ; Adamantyl

刊名：European Journal of Medicinal Chemistry

出版年：2016

8.siRNA delivered by EGFR-specific scFv sensitizes EGFR-TKI-resistant human lung cancer cells

作者：Yuan Lu^a ; ¹ ; Li Liu^a ; ^b ; ¹ ; Yuan Wang^a ; ¹ ; Fakai Li^a ; Jian Zhang^a ; Mingxiang Ye^a ; Hu Zhao^c ; Xiang Zhang^d ; Mi Zhang^e ; Jing Zhao^d ; Bo Yan^d ; Angang Yang^f ; Huasong Feng^e ; ^{fenghs99@163.com" class="auth_mail" title="E-mail the corresponding author} ; Rui Zhang^d ; ^{ruizhang@fmmu.edu.cn" class="auth_mail" title="E-mail the corresponding author} ; Xinling Ren^a ; ^{majrenxl@fmmu.edu.cn" class="auth_mail" title="E-mail the corresponding author}

关键词：NSCLC ; Tyrosine kinase inhibitors (TKIs) ; Resistance ; scFv ; Targeted therapy ; RNA interference

刊名：Biomaterials

出版年：2016

9.Anti-cancer synergy of dichloroacetate and EGFR tyrosine kinase inhibitors in NSCLC cell lines

作者：Zheng Yang ; Kin Y. Tam ; ^{kintam@umac.mo" class="auth_mail" title="E-mail the corresponding author}

关键词：Pyruvate dehydrogenase kinase ; Dichloroacetate ; Epidermal growth factor Receptor ; Erlotinib ; Gefitinib ; Drug combination

刊名：European Journal of Pharmacology

出版年：2016

10.Synthesis and biological evaluation of novel tricyclic oxazine and oxazepine fused quinazolines. Part 2: Gefitinib analogs

作者：Min Sun ; ^{sunmin@ask-pharm.com" class="auth_mail" title="E-mail the corresponding author} ; Jun Zhao ; Xiangfeng Chen ; Zaiwei Zong ; Jiyong Han ; Youguo Du ; Huanliang Sun ; Feidong Wang

关键词：Tricyclic fused quinazolines ; Antitumor activity ; EGFR ; HER2

刊名：Bioorganic & Medicinal Chemistry Letters

出版年：2016

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