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CNKI学位论文(152)
知网期刊论文(203)
在“
Elsevier电子期刊
”中,
命中:
210
条,耗时:0.0189886 秒
在所有数据库中总计命中:
355
条
1.
Structure-
activity
relationships of 4-hydroxy-4-biaryl-proline acylsulfonamide tripeptides: A series of potent
NS3
protease
inhibitor
s for the treatment of hepatitis C virus
作者:
Alan Xiangdong Wang
a
;
alan.wang@bms.com
;
Jie Chen
a
;
Qian Zhao
a
;
Li-Qiang Sun
a
;
Jacques Friborg
b
;
Fei Yu
b
;
Dennis Hernandez
b
;
Andrew C. Good
c
;
Herbert E. Klei
c
;
Ramkumar Rajamani
c
;
Kathy Mosure
d
;
Jay O. Knipe
d
;
Danshi Li
d
;
Jialong Zhu
d
;
Paul C. Levesque
d
;
Fiona McPhee
b
;
Nicholas A. Meanwell
a
;
Paul M. Scola
a
;
关键词:
HCV
NS3
/
4A
serine
protease
inhibitor
s
;
Tripeptide acylsulfonamides
;
C4 aryl
;
C4 hydroxy-proline
;
Potent and orally bioavailable
;
Cardiovascular profiles
刊名:Bioorganic & Medicinal Chemistry Letters
出版年:2017
2.
Large-Scale Structure-Based Prediction and Identification of Novel
Protease
Substrates Using Computational Protein Design
作者:
Manasi A. Pethe
1
;
2
;
Aliza B. Rubenstein
3
;
4
;
Sagar D. Khare
1
;
2
;
3
;
4
;
sagar.khare@rutgers.edu
关键词:
TEV
;
tobacco etch virus
protease
;
HCV
;
hepatitis C virus
protease
;
HIVPR
;
human immunodeficiency virus
protease
1
;
AUC
;
area under curve
;
ROC
;
receiver operator curve
;
SVM
;
support vector machine
;
YESS
;
Yeast Endoplasmic Reticulum Sequestration and Screening
;
TI
;
tetrahedral intermediate
刊名:Journal of Molecular Biology
出版年:2017
3.
Regulatory Analysis of Effects of Hepatitis C Virus NS5A Polymorphisms on Efficacy of Elbasvir and Grazoprevir
作者:
Takashi E. Komatsu
1
;
takashi.komatsu@fda.hhs.gov
;
Sarita Boyd
1
;
Adam Sherwat
1
;
LaRee Tracy
2
;
Lisa K. Naeger
1
;
Julian J. O&rsquo
;
Rear
1
;
Patrick R. Harrington
1
;
patrick.harrington@fda.hhs.gov
关键词:
DAA
;
Replication
;
FDA
;
Post-Hoc Analysis
刊名:Gastroenterology
出版年:2017
4.
Effectiveness of Elbasvir and Grazoprevir Combination, With or Without Ribavirin, for Treatment-Experienced Patients With Chronic Hepatitis C Infection
作者:
Paul Kwo
1
;
pkwo@stanford.edu
;
Edward J. Gane
2
;
Cheng-Yuan Peng
3
;
Brian Pearlman
4
;
John M. Vierling
5
;
Lawrence Serfaty
6
;
Maria Buti
7
;
Stephen Shafran
8
;
Paul Stryszak
9
;
Li Lin
9
;
Jacqueline Gress
9
;
Stuart Black
9
;
Frank J. Dutko
9
;
Michael Robertson
9
;
Janice Wahl
9
;
Lisa Lupinacci
9
;
Eliav Barr
9
;
Barbara Haber
9
关键词:
Hepatitis C
;
Randomized
;
Therapy
;
C-EDGE Treatment-Experienced
刊名:Gastroenterology
出版年:2017
5.
Novel fullerene derivatives as dual
inhibitor
s of Hepatitis C virus NS5B polymerase and
NS3
/
4A
protease
作者:
Hiroki Kataoka
a
;
Tomoyuki Ohe
a
;
ohe-tm@pha.keio.ac.jp" class="auth_mail" title="E-mail the corresponding author
;
Kyoko Takahashi
a
;
Shigeo Nakamura
b
;
Tadahiko Mashino
a
;
mashino-td@pha.keio.ac.jp" class="auth_mail" title="E-mail the corresponding author
关键词:
HCV
;
Hepatitis C virus
;
NS
;
non-structural
刊名:Bioorganic & Medicinal Chemistry Letters
出版年:2016
6.
Direct anti-
HCV
agents
作者:
Xingquan Zhang
xiz002@ucsd.edu" class="auth_mail" title="E-mail the corresponding author
关键词:
Hepatitis C virus
;
Cure
HCV
;
Sustained virologic response
;
Direct antiviral agents
;
NS3
/
4A
protease
inhibitor
刊名:Acta Pharmaceutica Sinica B
出版年:2016
7.
Efficacy of the Combination of Sofosbuvir, Velpatasvir, and the
NS3
/
4A
Protease
Inhibitor
GS-9857 in Treatment-Naïve or Previously Treated Patients With Hepatitis C Virus Genotype 1 or 3 Infections
作者:
Edward J. Gane
1
;
edgane@adhb.govt.nz" class="auth_mail" title="E-mail the corresponding author
;
Christian Schwabe
2
;
Robert H. Hyland
3
;
Yin Yang
3
;
Evguenia Svarovskaia
3
;
Luisa M. Stamm
3
;
Diana M. Brainard
3
;
John G. McHutchison
3
;
Catherine A. Stedman
4
关键词:
Clinical Trial
;
LEPTON
;
Difficult to Treat
;
Time of Treatment
刊名:Gastroenterology
出版年:2016
8.
Impact of
HCV
kinetics on treatment outcome differs by the type of real-time HCV assay in
NS3
/
4A
protease
inhibitor
-based triple therapy
作者:
Eiichi Ogawa
a
;
eogawa@gim.med.kyushu-u.ac.jp" class="auth_mail" title="E-mail the corresponding author
;
Norihiro Furusyo
a
;
Masayuki Murata
a
;
Takeo Hayashi
a
;
Motohiro Shimizu
a
;
Haru Mukae
a
;
Kazuhiro Toyoda
a
;
Taeko Hotta
b
;
Takeshi Uchiumi
b
;
Jun Hayashi
c
关键词:
Hepatitis C virus
;
Protease
inhibitor
;
Real-time PCR
;
Pegylated interferon
;
Simeprevir
刊名:Antiviral Research
出版年:2016
9.
Hepatitis C virus
NS3
/
4a
protease
inhibitor
s
作者:
John A McCauley
john_mccauley@merck.com" class="auth_mail" title="E-mail the corresponding author
;
Michael T Rudd
刊名:Current Opinion in Pharmacology
出版年:2016
10.
Effectiveness of Simeprevir Plus Sofosbuvir, With or Without Ribavirin, in Real-World Patients With
HCV
Genotype 1 Infection
作者:
Mark S. Sulkowski
1
;
msulkowski@jhmi.edu" class="auth_mail" title="E-mail the corresponding author
;
Hugo E. Vargas
2
;
Adrian M. Di Bisceglie
3
;
Alexander Kuo
4
;
K. Rajender Reddy
5
;
Joseph K. Lim
6
;
Giuseppe Morelli
7
;
Jama M. Darling
8
;
Jordan J. Feld
9
;
Robert S. Brown
10
;
Lynn M. Frazier
11
;
Thomas G. Stewart
8
;
Michael W. Fried
8
;
David R. Nelson
7
;
Ira M. Jacobson
12
;
for the
HCV
-TARGET Study GroupN. Afdhal
;
I. Alam
;
Z. Ben-Ari
;
J. Bredfeldt
;
R.S. Brown
;
R.T. Chung
;
J. Darling
;
W. Harlan
;
A.M. Di Bisceglie
;
R.C. Dickson
;
H.A. Elbeshbeshy
;
G. Everson
;
J. Feld
;
J.M. Fenkel
;
M.W. Fried
;
J. Galati
;
S.C. Gordon
;
M. Hassan
;
T.N. Hawkins
;
F. Hinestrosa
;
I.M. Jacobson
;
C.A. Kerr
;
A. Kuo
;
P.Y. Kwo
;
J. Levitsky
;
J. Lim
;
A.S. Lok
;
M. Mailliard
;
M.P. Manns
;
G. Morelli
;
A.J. Muir
;
D. Nelson
;
J.G. O&rsquo
;
Leary
;
B.L. Pearlman
;
P. Pockros
;
A. Ramani
;
N. Reau
;
K.R. Reddy
;
E.R. Schiff
;
K.E. Sherman
;
M.L. Shiffman
;
C. Smith
;
J.R. Spivey
;
R.K. Sterling
;
M.S. Sulkowski
;
G. Szabo
;
N.A. Terrault
;
C. Trautwein
;
H.E. Vargas
;
K. Watts
;
A. Williams
;
S. Zeuzem
关键词:
Chronic Hepatitis
;
Direct-Acting Agent
;
NS3
/
4A
Protease
Inhibitor
;
NS5B
刊名:Gastroenterology
出版年:2016
1
2
3
4
5
6
7
8
9
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