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在“Elsevier电子期刊”中，命中：1,009条，耗时：小于0.01 秒

1.Sampling only ten microliters of whole blood for the quantification of poorly soluble drugs: Itraconazole as case study

作者：Justine Thiry^a ; Brigitte Evrard^a ; Gwenaë ; l Nys^b ; Marianne Fillet^b ; Miranda G.M. Kok^b ; ^{miranda.kok@ulg.ac.be}

关键词：ACN ; acetonitrile ; BCS ; biopharmaceutics classification system ; DBS ; dried blood spot ; FA ; formic acid ; FDA ; food and drug administration ; HPLC ; high performance liquid chromatography ; IPA ; isopropanol ; ITZ ; itraconazole ; MeOH ; methanol ; MRM ; multiple reaction monitoring ; MS ; mass spectrometry ; OH-ITZ ; hydroxy-itraconazole ; TFA ; trifluoroacetic acid ; UHPLC ; ultra-high performance liquid chromatography ; UV ; ultraviolet ; VAMS ; volumetric absorptive microsampling

刊名：Journal of Chromatography A

出版年：2017

2.Anti-proliferation of breast cancer cells with itraconazole: Hedgehog pathway inhibition induces apoptosis and autophagic cell death

作者：Xiaoya Wang^a ; ^b ; ¹ ; ^{543596983@qq.com} ; Sanhua Wei^c ; ¹ ; ^{Sanhuawei3@163.com} ; Yong Zhao^a ; ¹ ; ^{zhaoyong8@aliyun.com} ; Changhong Shi^a ; ^{changhong@fmmu.edu.cn} ; Peijuan Liu^a ; ^{liupeij1989077@126.com} ; Caiqin Zhang^a ; ^{zhangcaiqin-beibei@163.com} ; Yingfeng Lei^d ; ^{yflei@fmmu.edu.cn} ; Bo Zhang^e ; ^{zhangbo@fmmu.edu.cn} ; Bing Bai^a ; ^{bone_1999@163.com} ; Yong Huang^b ; ^{Yonghuang@nwsuaf.edu.cn} ; Hai Zhang^a ; ^{hzhang@fmmu.edu.cn}

关键词：Breast cancer ; Itraconazole ; Apoptosis ; Autophagic cell death ; Hedgehog pathway

刊名：Cancer Letters

出版年：2017

3.Improved oral absorption profile of itraconazole in hypochlorhydria by self-micellizing solid dispersion approach

作者：Yoshiki Kojo ; Saori Matsunaga ; Hiroki Suzuki ; Hideyuki Sato ; Yoshiki Seto ; Satomi Onoue ; ^{onoue@u-shizuoka-ken.ac.jp}

关键词：ADI ; acceptable daily intake ; AUC ; area under the curve of blood concentration vs. time ; DLS ; dynamic light scattering ; DMEM ; Dulbecco's modified Eagle's medium ; DMSO ; dimethyl sulfoxide ; DSC ; differential scanning calorimetry ; GI ; gastrointestinal ; IEC6 cell ; intestinal epithelioid cell line No.6 derived from neonatal rat ileum ; ITZ ; itraconazole ; LD50 ; lethal dose 50% ; LDH ; lactate dehydrogenase ; NaPB ; sodium phosphate buffer ; PLM ; polarized light microscopy ; PXRD ; powder X-ray diffraction ; RH

刊名：European Journal of Pharmaceutical Sciences

出版年：2017

4.Bioavailability enhancement of itraconazole-based solid dispersions produced by hot melt extrusion in the framework of the Three Rs rule

作者：Justine Thiry^a ; ^{jthiry@ulg.ac.be} ; Miranda G.M. Kok^b ; Laurence Collard^a ; Antoine Frè ; re^a ; Fabrice Krier^a ; Marianne Fillet^b ; Brigitte Evrard^a

关键词：ACN ; acetonitrile ; API ; active pharmaceutical ingredient ; ASD ; amorphous solid dispersions ; AUC ; area under the curve ; BCS ; biopharmaceutics classification system ; CD ; cyclodextrin ; Cmax ; maximum concentration ; DSC ; differential scanning calorimetry ; FA ; formic acid ; FDA ; Food and Drug Administration ; HME ; hot melt extrusion ; HPLC ; high performance liquid chromatography ; IPA ; isopropanol ; ITZ ; itraconazole ; MeOH ; methanol ; MRM ; multiple reaction monitoring ; MS ; mass spectrometry ; ns ; not signifi

刊名：European Journal of Pharmaceutical Sciences

出版年：2017

5.Simultaneous determination of itraconazole, hydroxy itraconazole, keto itraconazole and N-desalkyl itraconazole concentration in human plasma using liquid chromatography with tandem mass spectrometry

作者：Xiaorong Liang^a ; ^{Liang.Xiaorong@gene.com" class="auth_mail" title="E-mail the corresponding author} ; Michael Van Parys^b ; Xiao Ding^a ; Ning Zeng^c ; Luke Bi^c ; Drew Dorshort^b ; Janine McKnight^b ; Dennis Milanowski^b ; Jialin Mao^a ; Yuan Chen^a ; Joseph A Ware^d ; Brian Dean^a ; Cornelis E.C.A. Hop^a ; Yuzhong Deng^a

关键词：LC&ndash ; MS ; Human plasma ; Itraconazole ; Hydroxy itraconazole ; Keto itraconazole ; N-desalkyl itraconazole ; Drug-drug interaction

刊名：Journal of Chromatography B, Analytical Technologies in the Biomedical and Life Sciences

出版年：2016

6.Impact of detergents on the physiochemical behavior of itraconazole loaded nanostructured lipid carriers

作者：A. Bhadra^a ; G. Karmakar^b ; P. Nahak^b ; P. Chettri^c ; B. Roy^b ; P. Guha^b ; A.K. Mandal^d ; R.K. Nath^e ; A.K. Panda^f ; ^{akpanda@mail.vidyasagar.ac.in} ; ^{akpanda1@yahoo.com}

关键词：NLC ; ITZ ; DLS ; DSC ; Drug release ; Antifungul activity

刊名：Colloids and Surfaces A: Physicochemical and Engineering Aspects

出版年：2017

7.Single jugular vein cannulated rats may not be suitable for intravenous pharmacokinetic screening of high logP compounds

作者：Nilesh Gaud^a ; Anoop Kumar^a ; Muralikrishna Matta^a ; Prashant Kole^a ; Srikanth Sridhar^c ; Sandhya Mandlekar^b ; Vinay K. Holenarsipur^a ; ^{vinay.gupta@syngeneintl.com}

关键词：Amiodarone ; Atenolol ; Blood sampling methods ; Dual cannulation ; Itraconazole ; Jugular vein ; Non-specific binding ; Rat pharmacokinetic studies

刊名：European Journal of Pharmaceutical Sciences

出版年：2017

8.Optimization and scaling-up of ITZ-based dry powders for inhalation

作者：Romain Merlos^a ; ^{rmerlos@ulb.ac.be} ; Nathalie Wauthoz^a ; ^{nawautho@ulb.ac.be} ; Vincent Levet^a ; ^{vlevet@ulb.ac.be} ; Laure Belhassan^b ; ^lbelh@smb.be ; Thami Sebti^b ; ^tsebt@smb.be ; Francis Vanderbist^b ; ^fvdbi@smb.be ; Karim Amighi^a ; ^{kamighi@ulb.ac.be}

关键词：Itraconazole ; Solid dispersion ; Pulmonary delivery ; Spray-drying ; Pilot-scale production

刊名：Journal of Drug Delivery Science and Technology

出版年：2017

9.The in vitro evaluation of ketoconazole and its alternative clinical CYP3A4/5 inhibitors (ritonavir, clarithromycin and itraconazole) as inhibitors of non-CYP enzymes

作者：David B. Buckley ; Brian W. Ogilvie ; Phyllis Yerino

刊名：Drug Metabolism and Pharmacokinetics

出版年：2017

10.Prevalence of Candida spp. in cervical-vaginal samples and the in vitro susceptibility of isolates

作者：Tchana Martinez Brandolt^a ; ^b ; Gabriel Baracy Klafke^a ; Carla Vitola Gonç ; alves^b ; Laura Riffel Bitencourt^a ; Ana Maria Barral de Martinez^b ; Josiara Furtado Mendes^c ; Má ; rio Carlos Araú ; jo Meireles^c ; Melissa Orzechowski Xavier^a ; ^b ; ^{melissaxavierfurg@gmail.com}

关键词：Vulvovaginal candidiasis ; Antifungal ; Susceptibility ; Resistance

刊名：Brazilian Journal of Microbiology

出版年：2017

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