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内部出版物
CNKI学位论文(231)
知网期刊论文(216)
在“
Elsevier电子期刊
”中,
命中:
58
条,耗时:0.0109953 秒
在所有数据库中总计命中:
447
条
1.
Identification of azabenzimidazoles as potent
JAK1
selective
inhibitors
作者:
Melissa M. Vasbinder
a
;
melissa.vasbinder@astrazeneca.com" class="auth_mail" title="E-mail the corresponding author
;
Marat Alimzhanov
a
;
Martin Augustin
d
;
Geraldine Bebernitz
a
;
Kirsten Bell
a
;
Claudio Chuaqui
a
;
Tracy Deegan
a
;
Andrew D. Ferguson
b
;
Kelly Goodwin
a
;
Dennis Huszar
a
;
Aarti Kawatkar
a
;
Sameer Kawatkar
a
;
Jon Read
c
;
Jie Shi
a
;
Stefan Steinbacher
d
;
Holger Steuber
d
;
Qibin Su
a
;
Dorin Toader
a
;
Haixia Wang
a
;
Richard Woessner
a
;
Allan Wu
b
;
Minwei Ye
a
;
Michael Zinda
a
关键词:
Azabenzimidazoles
;
JAK1
;
JAK selectivity
;
JAK1
inhibitors
刊名:Bioorganic & Medicinal Chemistry Letters
出版年:2016
2.
A novel JAK inhibitor, peficitinib, demonstrates potent efficacy in a rat adjuvant-induced arthritis model
作者:
Misato Ito
;
misato.ito@astellas.com
;
Shunji Yamazaki
;
Kaoru Yamagami
;
Masako Kuno
;
Yoshiaki Morita
;
Kenji Okuma
;
Koji Nakamura
;
Noboru Chida
;
Masamichi Inami
;
Takayuki Inoue
;
Shohei Shirakami
;
Yasuyuki Higashi
关键词:
Peficitinib
;
ASP015K
;
Janus kinase
;
Rheumatoid arthritis
;
Adjuvant-induced arthritis
刊名:Journal of Pharmacological Sciences
出版年:2017
3.
Structure-based design and development of (benz)imidazole pyridones as
JAK1
-selective kinase
inhibitors
作者:
Vladimir Simov
a
;
vladimir_simov@merck.com" class="auth_mail" title="E-mail the corresponding author
;
Sujal V. Deshmukh
c
;
Christopher J. Dinsmore
b
;
Fiona Elwood
a
;
Rafael B. Fernandez
a
;
Yudith Garcia
a
;
Craig Gibeau
a
;
Hakan Gunaydin
a
;
Joon Jung
d
;
Jason D. Katz
a
;
Brian Kraybill
e
;
Blair Lapointe
a
;
Sangita B. Patel
a
;
Tony Siu
a
;
Hua Su
a
;
Jonathan R. Young
f
关键词:
Janus Kinase
;
JAK1
kinase inhibitor
;
Structure-based design
刊名:Bioorganic & Medicinal Chemistry Letters
出版年:2016
4.
Ensemble docking-based virtual screening yields novel spirocyclic
JAK1
inhibitors
作者:
Dá
;
vid Bajusz
;
Gyö
;
rgy G. Ferenczy
;
Gyö
;
rgy M. Keserű
;
keseru.gyorgy@ttk.mta.hu
关键词:
AUC
;
area under the (ROC) curve
;
EF
;
enrichment factor
;
FDA
;
Food and Drug Administration
;
FPR
;
false positive rate
;
HTVS
;
high throughput virtual screening
;
JAK
;
Janus kinase
;
LLE
;
lipophilic ligand efficiency
;
LELP
;
lipophilicity-corrected ligand efficiency
;
PME
;
particle mesh Ewald [method]
;
ROC
;
receiver operating characteristic [curve]
;
SP
;
standard precision
;
STAT
;
signal transducers and activators of transcription
;
TPR
;
true positive rate
刊名:Journal of Molecular Graphics and Modelling
出版年:2016
5.
Outcomes of Allogeneic Hematopoietic Cell Transplantation in Patients with Myelofibrosis with Prior Exposure to Janus Kinase 1/2
Inhibitors
作者:
Mohamed Shanavas
1
;
Uday Popat
2
;
Laura C. Michaelis
3
;
Veena Fauble
4
;
Donal McLornan
5
;
Rebecca Klisovic
6
;
John Mascarenhas
7
;
Roni Tamari
8
;
Murat O. Arcasoy
9
;
James Davies
10
;
Usama Gergis
11
;
Oluchi C. Ukaegbu
12
;
Rammurti T. Kamble
13
;
John M. Storring
14
;
Navneet S. Majhail
15
;
Rizwan Romee
16
;
Srdan Verstovsek
17
;
Antonio Pagliuca
5
;
Sumithira Vasu
6
;
Brenda Ernst
4
;
Eshetu G. Atenafu
18
;
Ahmad Hanif
3
;
Richard Champlin
2
;
Paremeswaran Hari
3
;
Vikas Gupta
1
;
vikas.gupta@uhn.ca" class="auth_mail" title="E-mail the corresponding author
关键词:
JAK1
/2
inhibitors
;
Ruxolitinib
;
Myelofibrosis
;
Allogeneic transplantation
;
Survival
刊名:Biology of Blood and Marrow Transplantation
出版年:2016
6.
Feedback Activation of Leukemia Inhibitory Factor Receptor Limits Response to Histone Deacetylase
Inhibitors
in Breast Cancer
作者:
Hanlin Zeng
1
;
2
;
Jia Qu
1
;
2
;
Nan Jin
1
;
2
;
Jun Xu
1
;
Chenchu Lin
1
;
Yi Chen
1
;
Xinying Yang
1
;
Xiang He
1
;
Shuai Tang
1
;
Xiaojing Lan
1
;
Xiaotong Yang
1
;
Ziqi Chen
1
;
Min Huang
1
;
mhuang@simm.ac.cn" class="auth_mail" title="E-mail the corresponding author
;
Jian Ding
1
;
jding@simm.ac.cn" class="auth_mail" title="E-mail the corresponding author
;
Meiyu Geng
1
;
3
;
mygeng@simm.ac.cn" class="auth_mail" title="E-mail the corresponding author
关键词:
histone deacetylases
inhibitors
;
breast cancer
;
leukemia inhibitory factor receptor
;
STAT3
;
BET family proteins
刊名:Cancer Cell
出版年:2016
7.
The discovery of 2,5-isomers of triazole-pyrrolopyrimidine as selective Janus kinase 2 (JAK2)
inhibitors
versus
JAK1
and JAK3
作者:
Sun-Mi Lee
a
;
Kyoung Bin Yoon
b
;
Hyo Jeong Lee
b
;
Jiwon Kim
c
;
You Kyoung Chung
d
;
Won-Jea Cho
e
;
Chisato Mukai
f
;
Sun Choi
d
;
Keon Wook Kang
c
;
Sun-Young Han
b
;
syhan@gnu.ac.kr" class="auth_mail" title="E-mail the corresponding author
;
Hyojin Ko
g
;
kohyojin@gist.ac.kr" class="auth_mail" title="E-mail the corresponding author
;
Yong-Chul Kim
a
;
g
;
yongchul@gist.ac.kr" class="auth_mail" title="E-mail the corresponding author
关键词:
JAK2
;
JAK2V617F
;
JAK2 inhibitor
;
STAT (signal transducer and activator of transcription)
;
4-(2
;
5-Triazole)-pyrrolopyrimidine
刊名:Bioorganic & Medicinal Chemistry
出版年:2016
8.
Novel
JAK1
-selective benzimidazole
inhibitors
with enhanced membrane permeability
作者:
Hyungmi Kim
a
;
&dagger
;
;
Mi Kyoung Kim
a
;
&dagger
;
;
Hyunah Choo
b
;
c
;
Youhoon Chong
a
;
chongy@konkuk.ac.kr" class="auth_mail" title="E-mail the corresponding author
关键词:
Janus kinase
;
Rheumatoid arthritis
;
Benzimidazole
;
Selective inhibition
刊名:Bioorganic & Medicinal Chemistry Letters
出版年:2016
9.
Janus kinase (JAK)
inhibitors
in the treatment of inflammatory and neoplastic diseases
作者:
Robert Roskoski Jr.
rrj@brimr.org" class="auth_mail" title="E-mail the corresponding author
关键词:
ALL
;
acute lymphocytic leukemia
;
AML
;
acute myelogenous leukemia
;
AS
;
activation segment
;
CS or C-spine
;
catalytic spine
;
CL
;
catalytic loop
;
HΦ or Φ
;
hydrophobic
;
IFN
;
interferon
;
IL
;
interleukin
;
JAK1
/2
;
Janus kinases 1 and 2
;
MW
;
molecular weight
;
NSCLC
;
non-small cell lung cancer
;
PKA
;
protein kinase A
;
RA
;
rheumatoid arthritis
;
RS or R-spine
;
regulatory spine
;
Sh1
;
shell residue 1
;
TNF
;
tumor necrosis factor
刊名:Pharmacological Research
出版年:2016
10.
Molecular docking, 3D QSAR and dynamics simulation studies of imidazo-pyrrolopyridines as janus kinase 1 (JAK 1)
inhibitors
作者:
Ramesh Itteboina
;
Srilata Ballu
;
Sree Kanth Sivan
;
Vijjulatha Manga
;
vijjulathamanga@gmail.com" class="auth_mail" title="E-mail the corresponding author
关键词:
CoMFA
;
CoMSIA
;
PLS
;
JAK
;
SP
;
MD
刊名:Computational Biology and Chemistry
出版年:2016
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