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在“Elsevier电子期刊”中，命中：361条，耗时：小于0.01 秒

1.IMI - oral biopharmaceutics tools project - evaluation of bottom-up PBPK prediction success part 1: Characterisation of the OrBiTo database of compounds

作者：Alison Margolskee^a ; ^{alison.margolskee@manchester.ac.uk} ; Adam S. Darwich^a ; Xavier Pepin^b ; ^c ; Shriram M. Pathak^d ; Michael B. Bolger^e ; Leon Aarons^a ; Amin Rostami-Hodjegan^a ; ^d ; Jonas Angstenberger^f ; Franziska Graf^f ; Loic Laplanche^f ; Thomas Mü ; ller^f ; Sara Carlert^g ; Pankaj Daga^h ; Dó ; nal Murphy^b ; Christer Tannergren^g ; Mohammed Yasin^b ; Susanne Greschat-Schadeⁱ ; Wolfgang Mü ; ckⁱ ; Uwe Muensterⁱ ; Dorina van der Meyⁱ ; Kerstin Julia Frank^j ; Richard Lloyd^k ; Lieve Adriaenssen^l ; Jan Bevernage^l ; Loeckie De Zwart^l ; Dominique Swerts^l ; Christophe Tistaert^l ; An Van Den Bergh^l ; Achiel Van Peer^l ; Stefania Beato^m ; Anh-Thu Nguyen-Trung^m ; Joanne Bennettⁿ ; Mark McAllisterⁿ ; Mei Wongⁿ ; Patricia Zane^o ; Cé ; line Ollier^c ; Pascale Vicat^c ; Markus Kolhmann^p ; Alexander Marker^p ; Priscilla Brun^c ; Florent Mazuir^c ; Sté ; phane Beilles^c ; Marta Venczel^p ; Xavier Boulenc^c ; Petra Loos^p ; Hans Lennernä ; s^q ; Bertil Abrahamsson^g

关键词：API ; active pharmaceutical ingredient ; AUC ; area under the curve ; BCS ; biopharmaceutics classification system ; BP ; blood-to-plasma ratio ; Cmax ; maximum concentration ; CL ; clearance ; Do ; dose number according to BCS ; DDI ; drug-drug interaction ; EFPIA ; European Federation of Pharmaceutical Industries and Associations ; Foral ; absolute oral bioavailability ; Frel ; relative bioavailability ; fup ; fraction unbound in plasma ; IMI ; Innovative Medicines Initiative ; LogP ; logarithm of the octanol/water part

刊名：European Journal of Pharmaceutical Sciences

出版年：2017

2.Concentrations of antibiotics predicted to select for resistant bacteria: Proposed limits for environmental regulation

作者：Johan Bengtsson-Palme ^{johan@microbiology.se" class="auth_mail" title="E-mail the corresponding author} ; D.G. Joakim Larsson ; ^{joakim.larsson@fysiologi.gu.se" class="auth_mail" title="E-mail the corresponding author}

关键词：EC50 ; 50% effect concentration ; GMP ; Good manufacturing practice ; LOEC ; Lowest effect concentration ; MIC ; Minimal inhibitory concentration ; MSC ; Minimal selective concentration ; NOEC ; No effect concentration ; PNEC ; Predicted no effect concentration ; STP ; Sewage treatment plant

刊名：Environment International

出版年：2016

3.Chronic 14-day exposure to insecticides or methylmercury modulates neuronal activity in primary rat cortical cultures

作者：Milou M.L. Dingemans ^{m.dingemans@uu.nl} ; Marijke G. Schü ; tte ^{m.g.schutte@uu.nl} ; Daphne M.M. Wiersma ^{d.m.m.wiersma@uu.nl} ; Aart de Groot ^{a.degroot@uu.nl} ; Regina G.D.M. van Kleef ^{g.vankleef@uu.nl} ; Fiona M.J. Wijnolts ^{f.m.j.wijnolts@uu.nl} ; Remco H.S. Westerink ; ^{r.westerink@uu.nl}

关键词：ANOVA ; analysis of variance ; CAR ; carbaryl ; CP ; chlorpyrifos ; CPO ; chlorpyrifos-oxon ; CYP ; α-cypermethrin ; DIV ; days in vitro ; DMSO ; dimethyl sulfoxide ; ES ; endosulfan ; FBS ; fetal bovine serum ; ITS ; integrated testing strategies ; LOEC ; lowest observed effect concentration ; MEA ; micro-electrode array ; mISI ; median interspike interval ; MSR ; mean spike rate ; mwMEA ; multi-well micro-electrode array ; n ; number of wells ; NOEC ; no observed effect concentration ; PLL ; poly-l-lysine ; TR ; treatment ratio (

刊名：NeuroToxicology

出版年：2016

4.Biodynamics of copper oxide nanoparticles and copper ions in an oligochaete - Part II: Subcellular distribution following sediment exposure

作者：Amalie Thit^a ; ^b ; ^{athitj@ruc.dk" class="auth_mail" title="E-mail the corresponding author} ; Tina Ramskov^a ; ^b ; ^{tramskov@hotmail.com" class="auth_mail" title="E-mail the corresponding author} ; Marie-Noë ; le Croteau^b ; ^{mcroteau@usgs.gov" class="auth_mail" title="E-mail the corresponding author} ; Henriette Selck^a ; ^b

关键词：WSBB ; weight-specific body burden ; CD ; cellular debris ; d ; day(s) ; DI ; deionized water ; DL ; detection limit ; dw ; dry weight ; h ; hour(s) ; HDP ; heat denatured proteins ; LOEC ; lowest observed effect concentration ; min ; minutes ; MOD ; synthetic moderately hard freshwater ; MRG ; metal rich granules ; MTLP ; metallothionein-like proteins ; NOEC ; no observed effect concentration ; OECD ; the organization for economic co-operation and development ; Org ; Organelles ; t ; time ; US EPA ; the United States environment

刊名：Aquatic Toxicology

出版年：2016

5.Toxic and genotoxic effects of the 2,4-dichlorophenoxyacetic acid (2,4-D)-based herbicide on the Neotropical fish Cnesterodon decemmaculatus

作者：C. Ruiz de Arcaute^a ; ^b ; S. Soloneski^a ; ^b ; M.L. Larramendy^a ; ^b ; ^{marcelo.larramendy@gmail.com" class="auth_mail" title="E-mail the corresponding author}

关键词：AS ; Abnormal swimming ; BL ; Blebbed nuclei ; BN ; Binucleated erythrocyte ; CP ; Cyclophosphamide ; GBA ; Gathering at the bottom of the aquarium ; GDI ; Genetic damage index ; LC50 ; Lethal concentration 50 ; LB ; Lobed nuclei ; LOEC ; Lowest observed effect concentration ; MN ; Micronucleus ; NOEC ; No observed effect concentration ; NT ; Notched nuclei ; SCGE ; Single cell gel electrophoresis ; SM ; Slowness in motion ; SR ; Slow reaction

刊名：Ecotoxicology and Environmental Safety

出版年：2016

6.Estrogenic activity and nutrient losses in surface runoff after winter manure application to small watersheds

作者：N.W. Shappell^a ; ^{nancy.shappell@ars.usda.gov" class="auth_mail" title="E-mail the corresponding author} ; L.O. Billey^a ; ^{Lloyd.Billey@ars.usda.gov" class="auth_mail" title="E-mail the corresponding author} ; M.J. Shipitalo^b ; ^{Martin.Shipitalo@ars.usda.gov" class="auth_mail" title="E-mail the corresponding author}

关键词：E2 ; estradiol ; E2Eq ; estradiol equivalents ; CW ; Coshocton Wheel ; LC&ndash ; MS2 ; liquid-chromatography tandem-mass spectrometry ; LOEC ; lowest observable effect concentration ; MWTP ; municipal wastewater treatment plant ; NRCS ; National Resources Conservation Service ; npH2O ; nanopure H2O ; PNEC ; predicted no effect concentration ; SPE ; solid phase extraction ; TOC ; total organic carbon ; Total N ; total nitrogen ; WS ; watershed

刊名：Science of the Total Environment

出版年：2016

7.Elucidation of biotransformation of diclofenac and 4′hydroxydiclofenac during biological wastewater treatment

作者：Helene Bouju^a ; Peter Nastold^a ; Birgit Beck^b ; Juliane Hollender^b ; Philippe F.-X. Corvini^a ; ^c ; Thomas Wintgens^a ; ^{thomas.wintgens@fhnw.ch" class="auth_mail" title="E-mail the corresponding author}

关键词：AU ; arbitrary unit ; AGC ; automatic gain control ; DF ; diclofenac ; NSAID ; non-steroidal anti-inflammatory drugs ; LOEC ; lowest observed effect concentration ; HRT ; hydraulic retention time ; SRT ; solids retention time ; 4&prime ; -OHDF ; 4&prime ; -hydroxydiclofenac ; LC-ToF-MS ; liquid chromatography with time-of-flight mass spectrometry ; HRMS ; high resolution mass spectrometry ; MBR ; membrane bioreactor ; WWTP ; wastewater treatment plant ; LSC ; liquid scintillation counting analyser ; DAD ; diode array detectio

刊名：Journal of Hazardous Materials

出版年：2016

8.Estrone sulfate and dehydroepiandrosterone sulfate: Transactivation of the estrogen and androgen receptor

作者：Christian Bjerregaard-Olesen ; ^{cbjr@ph.au.dk" class="auth_mail" title="E-mail the corresponding author} ; Mandana Ghisari ; Lisbeth S. Kjeldsen ; Maria Wielsøe ; Eva C. Bonefeld-Jø ; rgensen

关键词：AR ; androgen receptor ; DC ; dextran/charcoal ; DHEA ; dehydroepiandrosterone ; DHEAS ; dehydroepiandrosterone sulfate ; DHT ; dihydrotestosterone ; E1 ; estrone ; E1S ; estrone sulfate ; E2 ; 17β-estradiol ; ER ; estrogen receptor ; FCS ; fetal calf serum ; HF ; hydroxyflutamide ; LDH ; lactate dehydrogenase ; LOEC ; lowest observed effect concentration ; MOEC ; maximum observed effect concentration ; PFAA ; perfluorinated alkyl acid ; STS ; steroid sulfatase

刊名：Steroids

出版年：2016

9.Activation of the estrogen receptor by human serum extracts containing mixtures of perfluorinated alkyl acids from pregnant women

作者：Christian Bjerregaard-Olesen ; Mandana Ghisari ; Eva C. Bonefeld-Jø ; rgensen ; ^{ebj@ph.au.dk" class="auth_mail" title="E-mail the corresponding author}

关键词：ANOVA ; analysis of variance ; BMI ; body mass index ; CD-FBS ; charcoal-dextran stripped fetal bovine serum ; CV ; co-variance ; DHEAS ; dehydroepiandrosterone sulfate ; DMEM ; Dulbecco's modified Eagle's media ; E1S ; estrone sulfate ; E2 ; 17β-estradiol ; EEQ ; estradiol equivalents ; ER ; estrogen receptor ; HPLC ; high performance liquid chromatography ; IQR ; interquartile range ; KHK ; pooled human female serum control ; LOEC ; lowest observed effect concentration ; LOQ ; limit of quantification ; PFAA ; perfluorinated

刊名：Environmental Research

出版年：2016

10.Site-specific water quality criteria for aquatic ecosystems: A case study of pentachlorophenol for Tai Lake, China

作者：Yi Chen^a ; ^b ; Shuangying Yu^c ; Song Tang^d ; Yabing Li^a ; Hongling Liu^a ; ^{hlliu@nju.edu.cn" class="auth_mail" title="E-mail the corresponding author} ; Xiaohui Zhang^a ; Guanyong Su^a ; Bing Li^b ; Hongxia Yu^a ; John P. Giesy^a ; ^e ; ^f ; ^g

关键词：WQC ; water quality criteria ; PCP ; pentachlorophenol ; 2 ; 4-DCP ; 2 ; 4-dichlorophenol ; SSDs ; species sensitivity distributions ; CMC ; criteria maximum concentration ; CCC ; criteria continuous concentration ; WER ; water effect ratio ; ACR ; acute-chronic ratio ; NOEC ; no observed effect concentration ; LOEC ; lowest observed effect concentration ; MATC ; maximum acceptable toxicant concentration ; EC50 ; 50% effective concentration ; LC50 ; 50% lethal concentration ; EC10 ; 10% effective concentration ; WQS ; water q

刊名：Science of the Total Environment

出版年：2016

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