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内部出版物
在“
Elsevier电子期刊
”中,
命中:
157
条,耗时:小于0.01 秒
1.
Design, synthesis and biological evaluation of [1,2,4]triazolo[1,5-a]pyrimidines as potent lysine specific demethylase 1 (
LSD1
/KDM1A) inhibitors
作者:
Shuai Wang
a
;
1
;
Li-Jie Zhao
a
;
1
;
Yi-Chao Zheng
a
;
Dan-Dan Shen
a
;
Er-Fei Miao
a
;
Xue-Peng Qiao
a
;
Li-Juan Zhao
a
;
Ying Liu
a
;
Ruilei Huang
b
;
Bin Yu
a
;
zzuyubin@hotmail.com
;
Hong-Min Liu
a
;
liuhm@zzu.edu.cn
关键词:
[1
2 ;
4]triazolo[1
;
5-a]pyrimidine
;
Cytotoxicity
;
LSD1
inactivation
;
Migration inhibition
;
Docking studies
刊名:European Journal of Medicinal Chemistry
出版年:2017
2.
Class I lysine deacetylases promote glucocorticoid-induced transcriptional repression through functional interaction with
LSD1
作者:
Nina M. Patrick
a
;
b
;
Chanel A. Griggs
b
;
Ali L. Icenogle
b
;
Maryam M. Gilpatrick
b
;
Vineela Kadiyala
b
;
c
;
1
;
Rosa Jaime-Frias
b
;
Catharine L. Smith
;
PhD
b
;
csmith@pharmacy.arizona.edu
关键词:
KDAC
;
lysine deacetylase
;
KDACi
;
lysine deacetylase inhibitor
;
KAT
;
lysine acetyltransferase
;
GR
;
glucocorticoid receptor
;
VPA
;
valproic acid
;
NR
;
nuclear receptor
;
Dex
;
dexamethasone
;
GAPDH
;
glyceraldehyde 3-phosphate dehydrogenase
;
HDAC
;
histone deacetylase
;
HDACi
;
HDAC inhibitor
;
HAT
;
histone acetyltransferase
;
RT-qPCR
;
real time quantitative polymerase chain reaction
;
Ct
;
threshold cycle
;
siRNA
;
small interfering RNA
;
LSD1
;
lysine-specific demethylase 1
;
AR
;
androgen receptor
;
CoREST
;
co-rep
刊名:The Journal of Steroid Biochemistry and Molecular Biology
出版年:2017
3.
Discovery of resveratrol derivatives as novel
LSD1
inhibitors: Design, synthesis and their biological evaluation
作者:
Ying-Chao Duan
a
;
Yuan-Yuan Guan
b
;
Xiao-Yu Zhai
a
;
Li-Na Ding
c
;
Wen-Ping Qin
a
;
Dan-Dan Shen
c
;
Xue-Qi Liu
c
;
Xu-Dong Sun
c
;
Yi-Chao Zheng
c
;
yichaozheng@zzu.edu.cn
;
Hong-Min Liu
c
;
liuhm@zzu.edu.cn
关键词:
Lysine-specific demethylase 1 inhibitors
;
Resveratrol derivatives
;
Synthesis
刊名:European Journal of Medicinal Chemistry
出版年:2017
4.
Neuro
LSD1
: Splicing-Generated Epigenetic Enhancer of Neuroplasticity
作者:
Francesco Rusconi
1
;
francesco.rusconi@unimi.it
;
Barbara Grillo
1
;
Emanuela Toffolo
1
;
Andrea Mattevi
2
;
Elena Battaglioli
1
;
3
;
elena.battaglioli@unimi.it
刊名:Trends in Neurosciences
出版年:2017
5.
LSD1
Makes Fat Colorful
作者:
Leon G. Straub
1
;
Christian Wolfrum
1
;
christian-wolfrum@ethz.ch
刊名:Trends in Endocrinology & Metabolism
出版年:2017
6.
Towards the development of activity-based probes for detection of lysine-specific demethylase-1 activity
作者:
Maria E. Ourailidou
a
;
Alessia Lenoci
b
;
Clemens Zwergel
b
;
Dante Rotili
b
;
Antonello Mai
b
;
c
;
antonello.mai@uniroma1.it
;
Frank J. Dekker
a
;
f.j.dekker@rug.nl
关键词:
Lysine demethylation
;
Tumorigenesis
;
Tranylcypromine
;
Irreversible inhibition
;
Enzyme labeling
刊名:Bioorganic & Medicinal Chemistry
出版年:2017
7.
Activation of lysine-specific demethylase 1 inhibitor peptide by redox-controlled cleavage of a traceless linker
作者:
Yuichi Amano
a
;
Naoki Umezawa
a
;
umezawa@phar.nagoya-cu.ac.jp
;
Shin Sato
b
;
Hisami Watanabe
b
;
Takashi Umehara
b
;
c
;
takashi.umehara@riken.jp
;
Tsunehiko Higuchi
a
;
higuchi@phar.nagoya-cu.ac.jp
关键词:
Epigenetics
;
Histone demethylase
;
Inhibitor peptide
;
Cyclic peptide
;
Traceless linker
;
Redox-responsive linker
刊名:Bioorganic & Medicinal Chemistry
出版年:2017
8.
Synthesis and biological evaluation of novel (E)-N′-(2,3-dihydro-1H-inden-1-ylidene) benzohydrazides as potent
LSD1
inhibitors
作者:
Yang Zhou
;
Yan Li
;
Wen-Jing Wang
;
Pu Xiang
;
Xin-Mei Luo
;
Li Yang
;
Sheng-Yong Yang
;
Ying-Lan Zhao
;
zhaoyinglan@scu.edu.cn" class="auth_mail" title="E-mail the corresponding author
关键词:
Histone methyltransferase
;
Lysine specific demethylase 1 (
LSD1
)
;
Conformational constraint
;
Anticancer
刊名:Bioorganic & Medicinal Chemistry Letters
出版年:2016
9.
The effects of
LSD1
inhibition on self-renewal and differentiation of human induced pluripotent stem cells
作者:
Hong-Jie Yan
a
;
b
;
1
;
Shu-Yan Zhou
a
;
b
;
1
;
Yang Li
a
;
b
;
Hui Zhang
c
;
Chun-Yan Deng
a
;
b
;
Hui Qi
a
;
b
;
Fu-Rong Li
a
;
b
;
frli62@163.com" class="auth_mail" title="E-mail the corresponding author
关键词:
LSD1
;
hiPSCs
;
Self-renewal
;
Differentiation
;
Mechanism
刊名:Experimental Cell Research
出版年:2016
10.
The histone demethylase
LSD1
is a novel oncogene and therapeutic target in oral cancer
作者:
Yanling Wang
a
;
1
;
Yumin Zhu
a
;
1
;
Qiong Wang
a
;
1
;
Huijun Hu
a
;
1
;
Zhongwu Li
a
;
b
;
Dongmiao Wang
b
;
Wei Zhang
c
;
Bin Qi
c
;
Jinhai Ye
b
;
Heming Wu
b
;
Hongbing Jiang
b
;
Laikui Liu
a
;
c
;
Jianrong Yang
a
;
b
;
Jie Cheng
a
;
omfs_njmu@163.com" class="auth_mail" title="E-mail the corresponding author
;
leonardo_cheng@163.com" class="auth_mail" title="E-mail the corresponding author
关键词:
LSD1
;
Histone demethylase
;
Epigenetic modification
;
Oral cancer
刊名:Cancer Letters
出版年:2016
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