搜索页_+MTDL

设为首页

收藏本站

网站地图 | English | 公务邮箱

About the library

Background
History
Leadership
Organization

Readers' Guide

Opening Hours
Collections
Help Via Email

Publications

Electronic Information Resources

常用资源

在“Elsevier电子期刊”中，命中：15条，耗时：小于0.01 秒

1.Design, synthesis, and pharmacological evaluation of multitarget-directed ligands with both serotonergic subtype 4 receptor (5-HT₄R) partial agonist and 5-HT₆R antagonist activities, as potential treatment of Alzheimer’s disease

作者：Samir Yahiaoui^a ; Katia Hamidouche^b ; Cé ; line Ballandonne^a ; Audrey Davis^a ; Jana Sopkova de Oliveira Santos^a ; Thomas Freret^b ; Michel Boulouard^b ; Christophe Rochais^a ; ^{christophe.rochais@unicaen.fr" class="auth_mail" title="E-mail the corresponding author} ; Patrick Dallemagne^a ; ^{patrick.dallemagne@unicaen.fr" class="auth_mail" title="E-mail the corresponding author}

关键词：Alzheimer&rsquo ; s disease ; MTDL ; 5-HT4 receptors agonists ; 5-HT6 receptors antagonists

刊名：European Journal of Medicinal Chemistry

出版年：2016

2.Design, synthesis and evaluation of novel ferulic acid-memoquin hybrids as potential multifunctional agents for the treatment of Alzheimer’s disease

作者：Wanli Pan^a ; Ke Hu^b ; Ping Bai^c ; Lintao Yu^a ; Qinge Ma^a ; Tao Li^a ; Xu Zhang^a ; Changzhong Chen^a ; Kelin Peng^a ; Wenmin Liu^a ; ^{liuwm1969@163.com" class="auth_mail" title="E-mail the corresponding author} ; Zhipei Sang^a ; ^{sangzhipei@163.com" class="auth_mail" title="E-mail the corresponding author}

关键词：AD ; Alzheimer&rsquo ; s disease ; AChE ; acetylcholinesterase ; BuChE ; butyrylcholinesterase ; Aβ ; β-amyloid peptide ; BBB ; blood&ndash ; brain barrier ; ACh ; acetylcholine ; MTDL ; multitarget-directed ligand ; EeAChE ; electric eel AChE ; CAS ; catalytic anionic site ; PAS ; peripheral anionic site ; ORAC-FL ; Oxygen Radicals Absorbance Capacity by Fluorescence ; ThT ; thioflavin T ; PAMPA-BBB ; parallel artificial membrane permeation assay of the blood&minus ; brain barrier

刊名：Bioorganic & Medicinal Chemistry Letters

出版年：2016

3.Novel benzylidenephenylpyrrolizinones with pleiotropic activities potentially useful in Alzheimer's disease treatment

作者：Jean-Pierre Jourdan^a ; Marc Since^a ; Laï ; la El Kihel^a ; Cé ; dric Lecoutey^a ; Sophie Corvaisier^a ; Ré ; mi Legay^a ; Jana Sopkova-de Oliveira Santos^a ; Thierry Cresteil^b ; Auré ; lie Malzert-Fré ; on^a ; Christophe Rochais^a ; ^{christophe.rochais@unicaen.fr" class="auth_mail" title="E-mail the corresponding author} ; Patrick Dallemagne^a ; ^{patrick.dallemagne@unicaen.fr" class="auth_mail" title="E-mail the corresponding author}

关键词：Alzheimer ; Pleiotrope ; MTDL ; Pyrrolizinone ; Antioxidant ; Antichelating ; Anti βA aggregation

刊名：European Journal of Medicinal Chemistry

出版年：2016

4.Multiple-tapped-delay-line hardware-linearisation technique based on wire load regulation

作者：Dariusz Chaberski^a ; ^{daras@fizyka.umk.pl" class="auth_mail" title="E-mail the corresponding author} ; Robert Frankowski^a ; ^{robef@fizyka.umk.pl" class="auth_mail" title="E-mail the corresponding author} ; Marek Zieliński^a ; ^{marziel@fizyka.umk.pl" class="auth_mail" title="E-mail the corresponding author} ; Łukasz Zaworski^b ; ^{lukasz.zaworski@gmail.com" class="auth_mail" title="E-mail the corresponding author}

关键词：FPGA ; LUT ; CLB ; Nonlinearity ; TDL ; VHDL ; Time-stamp ; Time-interval ; QNM ; MTDL ; TIMM ; TTDL ; FTTL

刊名：Measurement

出版年：2016

5.Molecular aspects of monoamine oxidase B

作者：Rona R. Ramsay ; ^{rrr@st-andrews.ac.uk" class="auth_mail" title="E-mail the corresponding author}

关键词：AD ; Alzheimer's Disease ; PD ; Parkinson's Disease ; DAT ; dopamine transporter ; SERT ; serotonin transporter ; NET ; noradrenaline transporter ; VMAT ; the vesicular transporter ; GPCR ; G-protein coupled receptor ; iPSC ; induced pluripotent stem cells ; SSRI ; serotonin reuptake inhibitor ; BDNF ; brain-derived neurotrophic factor ; MTDL ; multi-target designed ligands ; IC50 ; the concentration of compound required to inhibit a specified assay by 50% ; Ki ; a kinetically measured inhibitor dissociation constant

刊名：Progress in Neuropsychopharmacology & Biological Psychiatry

出版年：2016

6.A stable live bacterial vaccine

作者：Nitesh K. Kunda^a ; ¹ ; Denis Wafula^a ; ^b ; ¹ ; Meilinn Tram^a ; Terry H. Wu^c ; ^d ; Pavan Muttil^a ; ^{pmuttil@salud.unm.edu" class="auth_mail" title="E-mail the corresponding author}

关键词：Ft ; Francisella tularensis ; Lm ; recombinant attenuated Listeria monocytogenes expressing the Ft immune protective antigen pathogenicity island protein IglC ; RH ; relative humidity ; MTDLI ; mannitol ; trehalose ; dextran ; l-leucine myo-inositol

刊名：European Journal of Pharmaceutics and Biopharmaceutics

出版年：2016

7.Nicotinic ligands as multifunctional agents for the treatment of neuropsychiatric disorders

作者：Alvin V. Terry Jr. ; ^{aterry@gru.edu" class="auth_mail" title="E-mail the corresponding author} ; Patrick M. Callahan ; Caterina M. Hernandez

关键词：AChE ; acetylcholinesterase ; AD ; Alzheimer&rsquo ; s Disease ; DMTS ; delayed match to sample ; MLA ; methyllycaconitine ; NHP ; non-human primate ; NOR ; spontaneous novel object recognition

刊名：Biochemical Pharmacology

出版年：2015

8.Cystamine-tacrine dimer: A new multi-target-directed ligand as potential therapeutic agent for Alzheimer¡¯s disease treatment

作者：A. Minarini^a ; ^{anna.minarini@unibo.it} ; A. Milelli^a ; V. Tumiatti^a ; M. Rosini^a ; E. Simoni^a ; M.L. Bolognesi^a ; V. Andrisano^a ; M. Bartolini^a ; E. Motori^b ; C. Angeloni^b ; S. Hrelia^b

关键词：Tacrine ; Bis(7)tacrine ; Alzheimer&rsquo ; s disease ; MTDL ; Cystamine-tacrine dimer ; Oxidative injury

刊名：Neuropharmacology

出版年：2012

9.Synergistic effect of acetylcholinesterase inhibition (donepezil) and 5-HT₄ receptor activation (RS67333) on object recognition in mice

作者：Thomas Freret^a ; ^{thomas.freret@unicaen.fr} ; Valentine Bouet^a ; Anne Quiedeville^a ; Gé ; rald Nee^a ; Patrick Dallemagne^b ; Christophe Rochais^b ; Michel Boulouard^a ; ^{michel.boulouard@unicaen.fr}

关键词：5HT ; 5-hydroxytryptamine ; 5-HT4R ; 5-hydroxytryptamine (serotonin) receptor 4 ; AD ; Alzheimer's disease ; APP ; amyloid precursor protein ; DNPZ ; donepezil ; AChE ; acetylcholinesterase ; AChEi ; acetylcholinesterase inhibitor ; MTDL ; Multi-Target-Directed Ligand

刊名：Behavioural Brain Research

出版年：2012

10.Attenuating A¦Â_1-42-induced toxicity by a novel acetylcholinesterase inhibitor

作者：N. Mishra ; D. Sasmal ; K.K. Singh

关键词：AChE ; acetylcholinesterase ; AD ; Alzheimer&rsquo ; s disease ; A¦Â ; ¦Â-amyloid ; GSH ; glutathione ; MAO ; monoamine oxidase ; MTDL ; multi-target-directed ligand ; NP-9 ; 3-(anthracen-10-yl)-5-(3-nitrophenyl)-4 ; 5-dihydro-1H-pyrazole ; PAS ; peripheral anionic site ; S.

刊名：Neuroscience

出版年：2013

按检索点细分(15)

关键词(10)

文摘(8)

按出版年细分(15)

2027年及以后(1)

2016年(6)

2015年(1)

2013年(2)

2012年(3)

2011年(1)

2007年(1)