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在“
Elsevier电子期刊
”中,
命中:
78
条,耗时:小于0.01 秒
1.
Michael acceptor containing drugs are a novel class of 5-lipoxygenase inhibitor targeting the surface cysteines C416 and C418
作者:
Isabelle V. Maucher
a
;
Michael Rü
;
hl
a
;
Simon B.M. Kretschmer
a
;
Bettina Hofmann
a
;
Benjamin Kü
;
hn
a
;
Jasmin Fettel
a
;
Anja Vogel
a
;
b
;
Karsten T. Flü
;
gel
a
;
Georg Manolikakes
c
;
Nadine Hellmuth
a
;
Ann-Kathrin Hä
;
fner
a
;
Vahid Golghalyani
a
;
Ann-Katrin Ball
a
;
Matthias Piesche
d
;
g
;
Carmela Matrone
d
;
Gerd Geisslinger
b
;
e
;
Michael J. Parnham
b
;
Michael Karas
a
;
Dieter Steinhilber
a
;
Jessica Roos
a
;
1
;
roos@pharmchem.uni-frankfurt.de
;
Thorsten J. Maier
d
;
f
;
1
;
maier@biomed.au.dk
关键词:
AA
;
arachidonic acid
;
methyl-BQ
;
2
;
5-dimethyl-1
;
4-benzoquinone
;
CDDO
;
CDDO-methylester
;
methoxy-BQ
;
2
;
3-dimethoxy-5-methyl-p-benzoquinone
;
methoxy-NS
;
3-methoxy-β-nitrostyrene
;
DMF
;
dimethyl fumarate
;
GSH
;
glutathione
;
OH-BQ
;
2
;
5-dihydroxy-1
;
4-benzoquinone
;
HPLC
;
high-performance liquid chromatography
;
H(P)ETE
;
hydro (peroxy-) eicosatetraenoic acid
;
LT
;
leukotrienes
;
MS
;
mass spectrometry
;
NAC
;
N-acetylcysteine
;
NAPQI
;
N-acetyl-p-benzoquinone imine
;
NEM
;
N-ethylmaleimide
;
NFA
;
nitro-fatty acid
刊名:Biochemical Pharmacology
出版年:2017
2.
Activation of GR but not PXR by dexamethasone attenuated acetaminophen hepatotoxicities via Fgf21 induction
作者:
Saurabh G. Vispute
a
;
Pengli Bu
a
;
b
;
Yuan Le
a
;
Xingguo Cheng
a
;
chengx@stjohns.edu
关键词:
APAP
;
acetaminophen
;
bp
;
base pair
;
ChIP
;
chromatin immunoprecipitation
;
Cyp
;
cytochrome p450 enzyme
;
DEX
;
dexamethasone
;
Fgf21
;
fibroblast growth factor 21
;
GR
;
glucocorticoid receptor
;
GRE
;
glucocorticoid receptor response element
;
GSH
;
Glutathione
;
i.p.
;
intraperitoneal
;
NAPQI
;
N-acetyl-p-benzoquinone imine
;
PGC1α
;
peroxisome proliferator-activated receptor gamma coactivator protein-1α
;
PPAR
;
peroxisome proliferator-activated receptor
;
PXR
;
pregnane X receptor
;
TSS
;
transcription start site
刊名:Toxicology
出版年:2017
3.
Acetaminophen-induced hepatotoxicity: Preventive effect of trans anethole
作者:
Bruno Ambró
;
sio da Rocha
a
;
brunoambrosiorocha@gmail.com
;
Alessandra M. Versuti Ritter
b
;
ale_mileni@hotmail.com
;
Franciele Queiroz Ames
a
;
francieleames@gmail.com
;
Odinei Hess Gonç
;
alves
c
;
odinei@utfpr.edu.br
;
Fernanda Vitó
;
ria Leimann
c
;
fernanda@utfpr.edu.br
;
Lí
;
via Bracht
d
;
liviabracht@gmail.com
;
Maria Raquel Març
;
al Natali
e
;
mrmnatali@uem.br
;
Roberto Kenji Nakamura Cuman
a
;
Ciomar Ap. Bersani-Amado
a
;
cabamado@uem.br
关键词:
Trans anethole
;
Acetaminophen
;
Hepatoprotection
刊名:Biomedicine & Pharmacotherapy
出版年:2017
4.
Caffeic acid prevents acetaminophen-induced liver injury by activating the Keap1-Nrf2 antioxidative defense system
作者:
Chun Pang
a
;
c
;
1
;
Zhiyong Zheng
a
;
1
;
Liang Shi
a
;
Yuchen Sheng
b
;
Hai Wei
c
;
Zhengtao Wang
a
;
Lili Ji
a
;
lichenyue1307@126.com" class="auth_mail" title="E-mail the corresponding author
关键词:
APAP
;
acetaminophen
;
DILI
;
drug-induced liver injury
;
CA
;
Caffeic acid
;
ALT/AST
;
alanine/aspartate aminotransferases
;
MPO
;
myeloperoxidase
;
GSH
;
glutathione
;
ROS
;
reactive oxygen species
;
Nrf2
;
nuclear factor erythroid 2-related factor 2
;
HO-1
;
heme oxygenase 1
;
NQO1
;
NAD(P)H
;
quinone oxidoreductase 1
;
ZnPP
;
zinc protoporphyrin
;
Dim
;
diminutol
;
Keap1
;
kelch-like ECH-associated protein-1
;
CYP
;
cytochrome P450
;
NAPQI
;
N-acetyl-p-benzoquinone imine
;
NAC
;
N-acetylcysteine
;
H2DCFDA
;
2ʹ-7ʹ-Dichlorodih
刊名:Free Radical Biology and Medicine
出版年:2016
5.
Involvement of connexin43 in acetaminophen-induced liver injury
作者:
Michaë
;
l Maes
a
;
Mitchell R. McGill
b
;
1
;
Tereza Cristina da Silva
c
;
Chloé
;
Abels
d
;
e
;
Margitta Lebofsky
b
;
Cintia Maria Monteiro de Araú
;
jo
c
;
Taynã
;
Tiburcio
c
;
Isabel Veloso Alves Pereira
c
;
Joost Willebrords
a
;
Sara Crespo Yanguas
a
;
Anwar Farhood
f
;
Alain Beschin
d
;
e
;
Jo A. Van Ginderachter
d
;
e
;
Maria Lucia Zaidan Dagli
c
;
Hartmut Jaeschke
b
;
Bruno Cogliati
c
;
2
;
Mathieu Vinken
a
;
2
;
mvinken@vub.ac.be" class="auth_mail" title="E-mail the corresponding author
关键词:
ALT
;
alanine aminotransferase
;
APAP
;
acetaminophen
;
CD
;
cluster of differentiation
;
Cx
;
connexin
;
ELISA
;
enzyme-linked immunosorbent assay
;
GJIC
;
gap junctional intercellular communication
;
GSH
;
glutathione
;
GSSG
;
glutathione disulfide
;
hepaCAM
;
hepatocyte cell adhesion molecule
;
IFNγ
;
interferon γ
;
IL-1β/6/10
;
interleukin 1β/6/10
;
n
;
number of repeats
;
NAPQI
;
N-acetyl-p-benzoquinone imine
;
p
;
probability
;
RT-qPCR
;
reverse transcription quantitative real-time polymerase chain reaction
;
SEM
;
stan
刊名:Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease
出版年:2016
6.
Transcriptome association analysis identifies miR-375 as a major determinant of variable acetaminophen glucuronidation by human liver
作者:
Ioannis Papageorgiou
a
;
johnp@vetmed.wsu.edu" class="auth_mail" title="E-mail the corresponding author
;
Marina Freytsis
b
;
Marina.Freytsis@tufts.edu" class="auth_mail" title="E-mail the corresponding author
;
Michael H. Court
a
;
michael.court@vetmed.wsu.edu" class="auth_mail" title="E-mail the corresponding author
关键词:
ALF
;
acute liver failure
;
NAPQI
;
N-acetyl-p-benzoquinone imine
;
UGT
;
UDP-glucuronosyltransferase
;
SULT
;
sulfotransferase
;
CYP
;
cytochrome P450
;
3&prime
;
-UTR
;
3&prime
;
-untranslated region
;
SNP
;
single nucleotide polymorphism
;
miRNA
;
microRNA
;
UDPGA
;
uridine diphosphate glucuronic acid
;
qPCR
;
quantitative real-time PCR
;
AhR
;
aryl hydrocarbon receptor
;
MRE
;
miRNA response element
;
HNF1A
;
hepatocyte nuclear factor 1-alpha
;
HNF1B
;
hepatocyte nuclear factor 1-beta
;
Nrf2
;
nuclear factor erythroid 2-rel
刊名:Biochemical Pharmacology
出版年:2016
7.
Non-cytotoxic concentrations of acetaminophen induced mitochondrial biogenesis and antioxidant response in HepG2 cells
作者:
Tingfen Zhang
a
;
Qiang Zhang
b
;
Jiabin Guo
a
;
Haitao Yuan
a
;
Hui Peng
a
;
Lan Cui
a
;
Jian Yin
a
;
Li Zhang
a
;
Jun Zhao
a
;
Jin Li
c
;
Andrew White
c
;
Paul L. Carmichael
c
;
Carl Westmoreland
c
;
Shuangqing Peng
a
;
pengsq@hotmail.com" class="auth_mail" title="E-mail the corresponding author
关键词:
APAP
;
acetaminophen
;
GSH
;
glutathione
;
LDH
;
lactate dehydrogenase
;
mtDNA
;
mitochondrial DNA
;
MPT
;
mitochondrial permeability transition
;
MnSOD
;
manganese superoxide dismutase
;
NAPQI
;
N-acetyl-P-benzoquinoneimine
;
ND1
;
nicotinamide adenine dinucleotide (NADH) dehydrogenase subunit 1
;
NRF-1
;
nuclear respiratory factor 1
;
Nrf2
;
nuclear erythroid-2 like factor-2
;
PGC-1α
;
peroxisome proliferator-activated receptor γ coactivator-1α
;
SIRT1
;
silentmating type-information regulation 2 homolog 1
;
ROS
;
rea
刊名:Environmental Toxicology and Pharmacology
出版年:2016
8.
The fungicide thiabendazole causes apoptosis in rat hepatocytes
作者:
Marilyne Sé
;
ï
;
de
a
;
b
;
Michel Marion
a
;
Mircea Alexandru Mateescu
a
;
d
;
Diana A. Averill-Bates
a
;
b
;
c
;
d
;
averill.diana@uqam.ca" class="auth_mail" title="E-mail the corresponding author
关键词:
APAF-1
;
apoptosis protease activating factor-1
;
CYP
;
cytochrome P450
;
DISC
;
death inducing signaling complex
;
EROD
;
ethoxyresorufin-o-deethylase
;
FADD
;
Fas-associated death domain
;
FBS
;
fetal bovine serum
;
FCCP
;
carbonylcyanide p-trifluoromethoxyphenylhydrazone
;
GAPDH
;
glyceraldehyde-3-phosphate dehydrogenase
;
HRP
;
horseradish peroxidase
;
LDH
;
lactate dehydrogenase
;
MTT
;
methyl tetrazolium
;
NAPQI
;
N-acetyl-para-benzoquinone-imine
;
PI
;
propidium iodide
;
PROD
;
pentoxyresorufin-o-dealkylase
;
PVDF
刊名:Toxicology in Vitro
出版年:2016
9.
N-acetylcysteine amide, a promising antidote for acetaminophen toxicity
作者:
Ahdab Khayyat
a
;
Shakila Tobwala
a
;
Marcia Hart
b
;
Nuran Ercal
a
;
nercal@mst.edu" class="auth_mail" title="E-mail the corresponding author
关键词:
GSH-prodrug
;
Acetaminophen
;
Hepatotoxicity
;
Oxidative stress
;
NAPQI
;
Glutathione
刊名:Toxicology Letters
出版年:2016
10.
Experimental models of hepatotoxicity related to acute liver failure
作者:
Michaë
;
l Maes
a
;
Mathieu Vinken
a
;
1
;
mvinken@vub.ac.be" class="auth_mail" title="E-mail the corresponding author
;
Hartmut Jaeschke
b
;
1
关键词:
ALT
;
alanine aminotransferase
;
APAP
;
acetaminophen
;
ConA
;
concanavalin A
;
CYP
;
cytochrome P450
;
ET
;
endotoxin
;
FasL
;
Fas ligand
;
Gal
;
D-galactosamine
;
GSH
;
glutathione
;
IFNγ
;
interferon γ
;
NAPQI
;
N-acetyl-p-benzoquinone imine
;
p-JNK
;
c-jun N-terminal kinase activation
;
TNFα
;
tumor necrosis factor α
刊名:Toxicology and Applied Pharmacology
出版年:2016
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