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CNKI学位论文(1)
在“
Elsevier电子期刊
”中,
命中:
10
条,耗时:小于0.01 秒
在所有数据库中总计命中:
1
条
1.
Identification of structure-activity relationships for adverse effects of pharmaceuticals in humans: Part B. Use of (Q)SAR systems for early detection of drug-induced hepatobiliary and urinary tract t
作者:
Edwin J. Matthews
;
Carling J. Ursem
;
Naomi
L.
Kruhlak
;
R. Daniel Benz
;
David Aragoné
;
s Sabaté
;
Chihae Yang
;
Gilles Klopman
;
Joseph F. Contrera
关键词:
AERS
;
Computational toxicology
;
Drug adverse effects
;
Drug-induced liver injury
;
Drug-induced renal toxicity
;
In silico
;
Post-market reporting
;
Quantitative structure-activity relationships
;
QSAR software
;
SAR
;
SRS
刊名:Regulatory Toxicology and Pharmacology
出版年:2009
2.
Identification of structure–activity relationships for adverse effects of pharmaceuticals in humans: Part C: Use of QSAR and an expert system for the estimation of the mechanism of action of dr
作者:
Edwin J. Matthews
;
Naomi
L.
Kruhlak
;
R. Daniel Benz
;
David Aragoné
;
s Sabaté
;
Carol A. Marchant
;
Joseph F. Contrera
关键词:
Adverse drug effects
;
AERS
;
Clinical indication
;
Computational toxicology
;
Drug-induced kidney toxicity
;
Drug-induced liver toxicity
;
In silico
;
Mechanism of action
;
Pharmaceutical patent
;
Post-market reporting
;
Quantitative structure–
;
activi
刊名:Regulatory Toxicology and Pharmacology
出版年:2009
3.
Identification of structure–activity relationships for adverse effects of pharmaceuticals in humans. Part A: Use of FDA post-market reports to create a database of hepatobiliary and urinary tra
作者:
Carling J. Ursem
;
Naomi
L.
Kruhlak
;
Joseph F. Contrera
;
Philip M. MacLaughlin
;
R. Daniel Benz
;
Edwin J. Matthews
关键词:
AERS
;
Drug-induced kidney toxicity
;
Drug-induced liver toxicity
;
Human adverse effects
;
Post-market reporting
;
Quantitative structure–
;
activity relationships
;
QSAR
;
SRS
刊名:Regulatory Toxicology and Pharmacology
出版年:2009
4.
Comparison of MC4PC and MDL-QSAR rodent carcinogenicity predictions and the enhancement of predictive performance by combining QSAR models
作者:
Joseph F. Contrera
;
Naomi
L.
Kruhlak
;
Edwin J. Matthews
;
R. Daniel Benz
关键词:
Carcinogenicity
;
Discriminant analysis
;
In silico
;
Predictive toxicology
;
Topological descriptors
;
QSAR
;
E-state
;
Chemoinformatics
;
Discriminant analysis
;
Consensus prediction
刊名:Regulatory Toxicology and Pharmacology
出版年:2007
5.
A comprehensive model for reproductive and developmental toxicity hazard identification: I. Development of a weight of evidence QSAR database
作者:
Edwin J. Matthews
;
Naomi
L.
Kruhlak
;
R. Daniel Benz
;
Joseph F. Contrera
关键词:
Developmental toxicity
;
Dysmorphogenesis
;
Quantitative structure–
;
activity relationships
;
QSAR
;
Reproductive toxicity
;
Reprotox
;
Teratogenicity
;
Weight of evidence
刊名:Regulatory Toxicology and Pharmacology
出版年:2007
6.
A comprehensive model for reproductive and developmental toxicity hazard identification: II. Construction of QSAR models to predict activities of untested chemicals
作者:
Edwin J. Matthews
;
Naomi
L.
Kruhlak
;
R. Daniel Benz
;
Julian Ivanov
;
Gilles Klopman
;
Joseph F. Contrera
关键词:
MC4PC
;
Computational toxicology
;
Developmental toxicity
;
Dysmorphogenesis
;
Predictive modeling
;
Quantitative structure activity relationships (QSAR)
;
Reproductive toxicity
;
Reprotox
;
Teratogenicity
;
Weight of evidence
刊名:Regulatory Toxicology and Pharmacology
出版年:2007
7.
An analysis of genetic toxicity, reproductive and developmental toxicity, and carcinogenicity data: II. Identification of genotoxicants, reprotoxicants, and carcinogens using in silico methods
作者:
Edwin J. Matthews
;
Naomi
L.
Kruhlak
;
Michael C. Cimino
;
R. Daniel Benz and Joseph F. Contrera
关键词:
MC4PC
;
Computational toxicology
;
Quantitative structure–
;
activity relationships
;
Predictive modeling
;
Genetic toxicity
;
Genetox
;
Reproductive and developmental toxicity
;
Reprotox
;
Carcinogenicity
;
Rodent carcinogenicity bioassay
;
Surrogate
刊名:Regulatory Toxicology and Pharmacology
出版年:2006
8.
An analysis of genetic toxicity, reproductive and developmental toxicity, and carcinogenicity data: I. Identification of carcinogens using surrogate endpoints
作者:
Edwin J. Matthews
;
Naomi
L.
Kruhlak
;
Michael C. Cimino
;
R. Daniel Benz and Joseph F. Contrera
关键词:
Genetic toxicity
;
Genetox
;
Reproductive and developmental toxicity
;
Reprotox
;
Rodent carcinogenicity bioassay
;
Surrogate
;
Database
刊名:Regulatory Toxicology and Pharmacology
出版年:2006
9.
In silico screening of chemicals for bacterial mutagenicity using electrotopological E-state indices and MDL QSAR software
作者:
Joseph F. Contrera
;
Edwin J. Matthews
;
Naomi
L.
Kruhlak
and R. Daniel Benz
关键词:
QSAR
;
E-state indices
;
Electrotopological
;
Mutagenicity
;
In silico screening
;
Predictive toxicology
;
Drug development
;
Salmonella
;
Setubal principles
刊名:Regulatory Toxicology and Pharmacology
出版年:2005
10.
Estimating the safe starting dose in phase I clinical trials and no observed effect level based on QSAR modeling of the human maximum recommended daily dose
作者:
Contrera
;
Joseph F.
;
Matthews
;
Edwin J.
;
Kruhlak
;
Naomi
L.
;
Benz
;
R. Daniel
关键词:
Quantitative structure activity relationship
;
Maximum recommended daily dose
;
Maximum recommended safe starting dose
;
E-state descriptors
;
Predictive modeling
;
Safety factors
;
In silico modeling
;
Phase 1 clinical trials
;
No observed adverse effect level
刊名:Regulatory Toxicology and Pharmacology
出版年:2004
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