搜索页_+PDE1

设为首页

收藏本站

网站地图 | English | 公务邮箱

About the library

Background
History
Leadership
Organization

Readers' Guide

Opening Hours
Collections
Help Via Email

Publications

Electronic Information Resources

常用资源

在“Elsevier电子期刊”中，命中：254条，耗时：小于0.01 秒

1.Novel PDE10A transcript diversity in the human striatum: Insights into gene complexity, conservation and regulation

作者：Courtney M MacMullen^a ; Mohammad Fallahi^b ; Ronald L Davis^a ; ^{rdavis@scripps.edu}

关键词：SNP ; single nucleotide polymorphism ; cAMP ; cyclic adenosine monophosphate ; cGMP ; cyclic guanosine monophosphate ; MSN ; medium spiny neurons ; HC ; healthy control ; BD ; bipolar disorder ; RLM-RACE ; RNA ligase mediated rapid amplification of cDNA ends ; IRB ; institutional review board ; RNA ; ribonucleic acid ; NCBI ; National Center for Biotechnology ; RT-PCR ; reverse transcriptase polymerase chain reaction ; UCSC ; University of California Santa Cruz ; DNA ; deoxyribonucleic acid ; TFIIB ; transcription factor

刊名：Gene

出版年：2017

2.Cyclic nucleotide phosphodiesterases in human spermatozoa and seminal fluid: Presence of an active PDE10A in human spermatozoa

作者：Loï ; ze Maré ; chal^a ; ¹ ; Christine Guillemette^b ; ¹ ; Serge Goupil^a ; Patrick Blondin^c ; Pierre Leclerc^a ; Franç ; ois J. Richard^b ; ^{Francois.Richard@fsaa.ulaval.ca}

关键词：Spermatozoa ; Seminal plasma ; Phosphodiesterase

刊名：Biochimica et Biophysica Acta (BBA) - General Subjects

出版年：2017

3.Dopamine D₁ signaling involvement in the effects of the phosphodiesterase 10A inhibitor, PDM-042 on cognitive function and extrapyramidal side effect in rats

作者：Keita Arakawa^a ; Kazunari Nakao^b ; Shunsuke Maehara^a ; ^{shunsuke.maehara@mochida.co.jp" class="auth_mail" title="E-mail the corresponding author} ; ^{maehrasn@gmail.com" class="auth_mail" title="E-mail the corresponding author}

关键词：Phosphodiesterase 10A (PDE10A) ; Novel object recognition ; Catalepsy ; Dopamine ; Schizophrenia

刊名：Behavioural Brain Research

出版年：2017

4.Design and synthesis of potent and selective pyridazin-4(1H)-one-based PDE10A inhibitors interacting with Tyr683 in the PDE10A selectivity pocket

作者：Masato Yoshikawa ; ^{masato.yoshikawa@takeda.com" class="auth_mail" title="E-mail the corresponding author} ; Takenori Hitaka ; Tomoaki Hasui ; Makoto Fushimi ; Jun Kunitomo ; Hironori Kokubo ; Hideyuki Oki ; Kosuke Nakashima ; Takahiko Taniguchi

关键词：Phosphodiesterase 10A ; PDE10A ; Inhibitors ; Schizophrenia ; SBDD

刊名：Bioorganic & Medicinal Chemistry

出版年：2016

5.Development of highly potent phosphodiesterase 10A (PDE10A) inhibitors: Synthesis and in vitro evaluation of 1,8-dipyridinyl- and 1-pyridinyl-substituted imidazo[1,5-a]quinoxalines

作者：Sally Wagner^a ; ^{s.wagner@hzdr.de" class="auth_mail" title="E-mail the corresponding author} ; Matthias Scheunemann^a ; Karolin Dipper^a ; Ute Egerland^b ; Norbert Hoefgen^b ; Jö ; rg Steinbach^a ; Peter Brust^a

关键词：PDE10A inhibitor ; Imidazo[1 ; 5-a]quinoxalines ; PDE10A imaging agent

刊名：European Journal of Medicinal Chemistry

出版年：2016

6.PDE11A regulates social behaviors and is a key mechanism by which social experience sculpts the brain

作者：Shweta Hegde^a ; Hao Ji^b ; David Oliver^b ; Neema S. Patel^a ; Nicolas Poupore^a ; Michael Shtutman^b ; Michy P. Kelly^a ;

关键词：ANOVA ; analysis of variance ; CREB ; cAMP-response element binding protein ; GH ; group housed ; HT ; heterozygous ; KO ; knockout ; PDE11A ; Phosphodiesterase 11A ; Q-PCR ; quantitative PCR ; SI ; socially isolated ; VHIPP ; ventral hippocampal formation ; WT ; wild-type

刊名：Neuroscience

出版年：2016

7.Biochemical and behavioral effects of PDE10A inhibitors: Relationship to target site occupancy

作者：Yu-Wen Li^a ; ^{yu-wen.li@bms.com" class="auth_mail" title="E-mail the corresponding author} ; Matthew A. Seager^a ; Trevor Wojcik^a ; Karen Heman^a ; Thaddeus F. Molski^a ; Alda Fernandes^a ; Shaun Langdon^a ; Annapurna Pendri^b ; Samuel Gerritz^b ; Yuan Tian^c ; Yang Hong^c ; Lizbeth Gallagher^d ; James R. Merritt^e ; ¹ ; Chongwu Zhang^e ; Ryan Westphal^a ; ² ; Robert Zaczek^a ; ³ ; John E. Macor^b ; Joanne J. Bronson^b ; Nicholas J. Lodge^a

关键词：PDE10A ; Antipsychotic ; Conditioned avoidance response ; Catalepsy ; Radioligand ; Occupancy

刊名：Neuropharmacology

出版年：2016

8.Cardiac Adenylyl Cyclase and Phosphodiesterase Expression Profiles Vary by Age, Disease, and Chronic Phosphodiesterase Inhibitor Treatment

作者：Stephanie J. Nakano ; MD¹ ; Juliana Sucharov² ; Robert van Dusen ; BS³ ; Mackenzie Cecil² ; Karin Nunley ; MS⁴ ; Sean Wickers⁵ ; Anis Karimpur-Fard ; PhD⁶ ; Brian L. Stauffer ; MD⁴ ; ⁷ ; Shelley D. Miyamoto ; MD¹ ; Carmen C. Sucharov ; PhD⁴ ; ^{kika.sucharov@ucdenver.edu}

关键词：Adenylyl cyclase ; phosphodiesterase ; single ventricle congenital heart disease ; dilated cardiomyopathy

刊名：Journal of Cardiac Failure

出版年：2017

9.Proteome-Scale Investigation of Protein Allosteric Regulation Perturbed by Somatic Mutations in 7,000 Cancer Genomes

作者：Qiancheng Shen¹ ; ⁸ ; Feixiong Cheng² ; ³ ; ⁶ ; ⁷ ; ⁸ ; Huili Song¹ ; Weiqiang Lu⁴ ; Junfei Zhao³ ; Xiaoli An¹ ; Mingyao Liu⁴ ; Guoqiang Chen¹ ; Zhongming Zhao⁵ ; ^{zhongming.zhao@uth.tmc.edu} ; Jian Zhang¹ ; ^{jian.zhang@sjtu.edu.cn}

刊名：The American Journal of Human Genetics

出版年：2017

10.Fragment-assisted hit investigation involving integrated HTS and fragment screening: Application to the identification of phosphodiesterase 10A (PDE10A) inhibitors

作者：Jeffrey G. Varnes^a ; ^{jeffrey.varnes@astrazeneca.com" class="auth_mail" title="E-mail the corresponding author} ; Stefan Geschwindner^b ; Christopher R. Holmquist^a ; Janet Forst^a ; Xia Wang^a ; Niek Dekker^b ; Clay W. Scott^a ; Gaochao Tian^a ; Michael W. Wood^a ; Jeffrey S. Albert^a ; ^{jeffrey.albert@intellisynrd.com" class="auth_mail" title="E-mail the corresponding author}

关键词：PDE10A ; Fragment-based drug discovery ; Fragment-assisted drug discovery ; Phosphodiesterase inhibitor ; Schizophrenia

刊名：Bioorganic & Medicinal Chemistry Letters

出版年：2016

按检索点细分(254)

题名(88)

作者(1)

关键词(71)

文摘(224)

按出版年细分(254)

2027年及以后(11)

2017年(5)

2016年(16)

2015年(8)

2014年(1)

2013年(14)

2012年(24)

2011年(22)

2010年(16)

2009年(14)

2008年(14)

2007年(20)

2006年(11)

2005年(8)

2004年(9)

2003年(13)

2002年(6)

2001年(10)

2000年(3)

2000年及以前(29)