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在“Elsevier电子期刊”中，命中：2,030条，耗时：0.0439785 秒

在所有数据库中总计命中：19,747条

1.Identification, bioactivity evaluation and pharmacokinetics of multiple components in rat serum after oral administration of Xian-Ling-Gu-Bao capsule by ultra performance liquid chromatography coupled with quadrupole time-of-flight tandem mass spectrometry

作者：Zhi-Hong Yao^a ; ¹ ; ^{tyaozh@jnu.edu.cn} ; ^{yaozhihong.jnu@gmail.com} ; Zi-Fei Qin^a ; ¹ ; Liang-Liang He^a ; Xin-Luan Wang^b ; ^c ; Yi Dai^a ; ^{daiyi1004@163.com} ; Ling Qin^b ; ^c ; Frank J. Gonzalez^d ; Wen-Cai Ye^a ; Xin-Sheng Yao^a

关键词：Xian-Ling-Gu-Bao capsule ; Main prototypes ; Bioactivity evaluation ; Pharmacokinetics ; Rat serum ; UPLC/Q-TOF-MS

刊名：Journal of Chromatography B

出版年：2017

2.Pharmacokinetic variability, efficacy and tolerability of eslicarbazepine acetate-A national approach to the evaluation of therapeutic drug monitoring data and clinical outcome

作者：Torleiv Svendsen^a ; ^{torle-sv@online.no} ; ^{Torleiv.Svendsen@ous-hf.no} ; Eylert Brodtkorb^b ; ^c ; Arne Reimers^d ; ^e ; Espen Molden^f ; Erik Sæ ; tre^a ; Svein I. Johannessen^a ; ^g ; Cecilie Johannessen Landmark^a ; ^g ; ^h

关键词：Antiepileptic drugs ; Epilepsy ; Eslicarbazepine acetate ; Pharmacokinetic variability ; Retention rate ; Therapeutic drug monitoring (TDM)

刊名：Epilepsy Research

出版年：2017

3.Improved anti-hyperlipidemic activity of Rosuvastatin Calcium via lipid nanoparticles: Pharmacokinetic and pharmacodynamic evaluation

作者：Narendar Dudhipala ; Kishan Veerabrahma ; ^{vbkishan@yahoo.com}

关键词：Solid lipid nanoparticles ; Rosuvastatin calcium ; SEM ; Extent of absorption ; Pharmacokinetics ; Pharmacodynamics

刊名：European Journal of Pharmaceutics and Biopharmaceutics

出版年：2017

4.Brain delivery of baclofen as a hydrophilic drug by nanolipid carriers: Characteristics and pharmacokinetics evaluation

作者：Elham Ghasemian ; Alireza Vatanara ; ^{vatanara@tums.ac.ir} ; Nima Navidi ; Mohammad Reza Rouini

关键词：Baclofen ; NLC ; Sustained release ; Brain delivery ; Spasm

刊名：Journal of Drug Delivery Science and Technology

出版年：2017

5.Efavirenz dissolution enhancement III: Colloid milling, pharmacokinetics and electronic tongue evaluation

作者：Cristiane R.D. Hoffmeister^a ; Cinira Fandaruff^b ; Maí ; ra A. da Costa^a ; Lucio M. Cabral^c ; Luciana R. Pitta^d ; Stanley E.R. Bilatto^e ; ^f ; Livia D. Prado^a ; Daniel S. Corrê ; a^e ; ^f ; Leandro Tasso^g ; Marcos Antô ; nio S. Silva^b ; Helvé ; cio V.A. Rocha^a ; ^c ; ^{helveciorocha@far.fiocruz.br}

关键词：EFV ; efavirenz ; NNRTI ; non-nucleoside reverse transcriptase inhibitor ; HIV-1/AIDS ; human immunodeficiency virus type 1 infection ; SLS ; sodium lauryl sulfate ; HPC ; hydroxypropylcellulose ; HPMC ; hydroxypropylmetilcellulose ; NRTIs ; nucleoside reverse transcriptase inhibitors ; API ; active pharmaceutical ingredient ; CD ; cyclodextrin ; FDA ; Food and Drug Administration ; AUC ; area under the curve

刊名：European Journal of Pharmaceutical Sciences

出版年：2017

6.Discovery of hepatitis B virus capsid assembly inhibitors leading to a heteroaryldihydropyrimidine based clinical candidate (GLS4)

作者：Qingyun Ren^a ; ^b ; Xinchang Liu^a ; ^b ; Zhonghua Luo^a ; Jing Li^a ; Chaolei Wang^a ; ^b ; Siegfried Goldmann^a ; ^{sigi@hecpharm.com} ; Jiancun Zhang^c ; Yingjun Zhang^a ; ^{zhangyingjun@hecpharm.com}

关键词：HBV ; Capsid assembly inhibitor ; SAR ; GLS4 ; Pharmacokinetics ; Safety evaluation

刊名：Bioorganic & Medicinal Chemistry

出版年：2017

7.Chiral resolution of serial potent and selective σ₁ ligands and biological evaluation of (−)-[¹⁸F]TZ3108 in rodent and the nonhuman primate brain

作者：Xuyi Yue^a ; Hongjun Jin^a ; Zonghua Luo^a ; Hui Liu^a ; Xiang Zhang^a ; Ethan D. McSpadden^b ; Linlin Tian^c ; Hubert P. Flores^c ; Joel S. Perlmutter^a ; ^c ; Stanley M. Parsons^b ; Zhude Tu^a ; ^{tuz@mir.wustl.edu}

关键词：calcd ; calculated ; CH2Cl2 ; dichloromethane ; CNS ; central nervous system ; DMSO ; dimethyl sulfoxide ; [3H]DTG ; [3H]ditolylguanidine ; DTTA ; di-p-toluoyl tartaric acid ; EBP ; emopamil binding protein ; ee ; enantiomeric excess ; EOB ; end of bombardment ; EtOH ; ethanol ; [18F]FTC146 ; 18F-6-(3-fluoropropyl)-3-(2-(azepan-1-yl)ethyl)benzo[d]thiazol-2(3H)-one ; HPLC ; high performance liquid chromatography ; HRMS ; high resolution mass spectrometry ; IC50 ; half maximum inhibitory constant ; K2CO3 ; potassium carbonate

刊名：Bioorganic & Medicinal Chemistry

出版年：2017

8.IMI - oral biopharmaceutics tools project - evaluation of bottom-up PBPK prediction success part 1: Characterisation of the OrBiTo database of compounds

作者：Alison Margolskee^a ; ^{alison.margolskee@manchester.ac.uk} ; Adam S. Darwich^a ; Xavier Pepin^b ; ^c ; Shriram M. Pathak^d ; Michael B. Bolger^e ; Leon Aarons^a ; Amin Rostami-Hodjegan^a ; ^d ; Jonas Angstenberger^f ; Franziska Graf^f ; Loic Laplanche^f ; Thomas Mü ; ller^f ; Sara Carlert^g ; Pankaj Daga^h ; Dó ; nal Murphy^b ; Christer Tannergren^g ; Mohammed Yasin^b ; Susanne Greschat-Schadeⁱ ; Wolfgang Mü ; ckⁱ ; Uwe Muensterⁱ ; Dorina van der Meyⁱ ; Kerstin Julia Frank^j ; Richard Lloyd^k ; Lieve Adriaenssen^l ; Jan Bevernage^l ; Loeckie De Zwart^l ; Dominique Swerts^l ; Christophe Tistaert^l ; An Van Den Bergh^l ; Achiel Van Peer^l ; Stefania Beato^m ; Anh-Thu Nguyen-Trung^m ; Joanne Bennettⁿ ; Mark McAllisterⁿ ; Mei Wongⁿ ; Patricia Zane^o ; Cé ; line Ollier^c ; Pascale Vicat^c ; Markus Kolhmann^p ; Alexander Marker^p ; Priscilla Brun^c ; Florent Mazuir^c ; Sté ; phane Beilles^c ; Marta Venczel^p ; Xavier Boulenc^c ; Petra Loos^p ; Hans Lennernä ; s^q ; Bertil Abrahamsson^g

关键词：API ; active pharmaceutical ingredient ; AUC ; area under the curve ; BCS ; biopharmaceutics classification system ; BP ; blood-to-plasma ratio ; Cmax ; maximum concentration ; CL ; clearance ; Do ; dose number according to BCS ; DDI ; drug-drug interaction ; EFPIA ; European Federation of Pharmaceutical Industries and Associations ; Foral ; absolute oral bioavailability ; Frel ; relative bioavailability ; fup ; fraction unbound in plasma ; IMI ; Innovative Medicines Initiative ; LogP ; logarithm of the octanol/water part

刊名：European Journal of Pharmaceutical Sciences

出版年：2017

9.IMI - Oral biopharmaceutics tools project - Evaluation of bottom-up PBPK prediction success part 2: An introduction to the simulation exercise and overview of results

作者：Alison Margolskee^a ; ^{alison.margolskee@manchester.ac.uk} ; Adam S. Darwich^a ; Xavier Pepin^b ; ^c ; Leon Aarons^a ; Aleksandra Galetin^a ; Amin Rostami-Hodjegan^a ; ^d ; Sara Carlert^e ; Maria Hammarberg^e ; Constanze Hilgendorf^e ; Pernilla Johansson^e ; Eva Karlsson^e ; Dó ; nal Murphy^b ; Christer Tannergren^e ; Helena Thö ; rn^e ; Mohammed Yasin^b ; Florent Mazuir^c ; Olivier Nicolas^c ; Sergej Ramusovic^f ; Christine Xu^g ; Shriram M. Pathak^d ; Timo Korjamo^h ; Johanna Laru^b ; ^h ; Jussi Malkki^h ; Sari Pappinen^h ; Johanna Tuunainen^h ; Jennifer Dressmanⁱ ; Simone Hansmannⁱ ; Edmund Kostewiczⁱ ; Handan He^j ; Tycho Heimbach^j ; Fan Wu^j ; Carolin Hoft^k ; Loic Laplanche^k ; Yan Pang^k ; Michael B. Bolger^l ; Eva Huehn^l ; Viera Lukacova^l ; James M. Mullin^l ; Ke X. Szeto^l ; Chester Costales^m ; Jian Lin^m ; Mark McAllisterⁿ ; Sweta Modi^m ; Charles Rotter^m ; Manthena Varmaⁿ ; Mei Wongⁿ ; Amitava Mitra^o ; Jan Bevernage^p ; Jeike Biewenga^p ; Achiel Van Peer^p

关键词：API ; Active pharmaceutical ingredient ; AUC ; Area under the curve ; BCS ; Biopharmaceutics classification system ; BE ; Bioequivalence ; BP ; Blood-to-plasma ratio ; CL ; Clearance ; CL/F ; Apparent clearance ; Cmax ; Maximum concentration ; Do ; Dose number ; fa ; Fraction absorbed ; FIM ; First in man ; Foral ; Absolute oral bioavailability ; Frel ; Relative bioavailability ; fup ; Fraction unbound in plasma ; IMI ; Innovative Medicines Initiative ; i.v. ; Intravenous ; IR ; Immediate release ; LogP ; Logarithm of the octanol

刊名：European Journal of Pharmaceutical Sciences

出版年：2017

10.Magnesium, zinc and calcium aluminium layered double hydroxide-drug nanohybrids: A comprehensive study

作者：Suman Saha^a ; Sayantan Ray^a ; Rituparna Acharya^b ; Tapan Kumar Chatterjee^b ; Jui Chakraborty^a ; ^{jui@cgcri.res.in}

关键词：MgAl/ZnAl/CaAl-LDH synthesis ; Physicochemical properties ; In vitro drug release ; In vitro cytotoxicity and in vivo toxicology ; Pharmacokinetic evaluation ; Cellular uptake ; Targeted delivery

刊名：Applied Clay Science

出版年：2017

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