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CNKI学位论文(133)
知网期刊论文(140)
在“
Elsevier电子期刊
”中,
命中:
366
条,耗时:0.035984 秒
在所有数据库中总计命中:
273
条
1.
The drug candidate, ADX71441, is a novel, potent and selective
positive
allosteric
modulator
of the GABA
B
receptor with a potential for treatment of anxiety, pain and spasticity
作者:
Mikhail Kalinichev
;
mikhail.kalinichev@ipsen.com
;
Franç
;
oise Girard
;
Hasnaà
;
Haddouk
;
Mé
;
lanie Rouillier
;
Eric Riguet
;
Isabelle Royer-Urios
;
Vincent Mutel
;
Robert Lü
;
tjens
;
Sonia Poli
关键词:
Allosteric
modulator
;
GABA
;
Anxiety
;
Pain
;
Body temperature
;
Baclofen
;
Spasticity
;
Clinical candidate
刊名:Neuropharmacology
出版年:2017
2.
3-Furan-2-yl-N-p-tolyl-acrylamide, a
positive
allosteric
modulator
of the α7 nicotinic receptor, reverses schizophrenia-like cognitive and social deficits in rats
作者:
Agnieszka Potasiewicz
a
;
Małgorzata Hołuj
a
;
Tomasz Kos
a
;
Piotr Popik
a
;
Hugo R. Arias
b
;
Agnieszka Nikiforuk
a
;
nikifor@if-pan.krakow.pl
关键词:
α7 Nicotinic acetylcholine receptors
;
Positive
allosteric
modulator
;
Animal model of schizophrenia
;
Cognitive flexibility
;
Recognition memory
;
Antipsychotics
刊名:Neuropharmacology
出版年:2017
3.
Challenges in the development of an M
4
PAM in vivo tool compound: The discovery of VU0467154 and unexpected DMPK profiles of close analogs
作者:
Michael R. Wood
a
;
c
;
1
;
Meredith J. Noetzel
a
;
b
;
1
;
Michael S. Poslusney
a
;
1
;
Bruce J. Melancon
a
;
b
;
James C. Tarr
a
;
Atin Lamsal
a
;
Sichen Chang
a
;
Vincent B. Luscombe
a
;
b
;
Rebecca L. Weiner
a
;
b
;
Hyekyung P. Cho
a
;
b
;
Michael Bubser
a
;
Carrie K. Jones
a
;
b
;
e
;
Colleen M. Niswender
a
;
b
;
e
;
Michael W. Wood
d
;
Darren W. Engers
a
;
b
;
Nicholas J. Brandon
d
;
Mark E. Duggan
d
;
P. Jeffrey Conn
a
;
b
;
e
;
Thomas M. Bridges
a
;
b
;
thomas.m.bridges@vanderbilt.edu
;
Craig W. Lindsley
a
;
b
;
c
;
craig.lindsley@vanderbilt.edu
关键词:
M4
;
Muscarinic acetylcholine receptor
;
Positive
allosteric
modulator
(PAM)
;
Schizophrenia
;
Structure-activity relationship (SAR)
刊名:Bioorganic & Medicinal Chemistry Letters
出版年:2017
4.
Triazolopyridine ethers as potent, orally active mGlu
2
positive
allosteric
modulator
s for treating schizophrenia
作者:
Mendi A. Higgins
;
mendi.higgins@bms.com
;
Lawrence R. Marcin
;
F. Christopher Zusi
;
Robert Gentles
;
Min Ding
;
Bradley C. Pearce
;
Amy Easton
;
Walter A. Kostich
;
Matthew A. Seager
;
Clotilde Bourin
;
Linda J. Bristow
;
Kim A. Johnson
;
Regina Miller
;
John Hogan
;
Valerie Whiterock
;
Michael Gulianello
;
Meredith Ferrante
;
Yanling Huang
;
Adam Hendricson
;
Andrew Alt
;
John E. Macor
;
Joanne J. Bronson
关键词:
Schizophrenia
;
mGlu2
;
Metabotropic glutamate receptors
;
Triazolopyridine
刊名:Bioorganic & Medicinal Chemistry
出版年:2017
5.
The GABA
B
positive
allosteric
modulator
s CGP7930 and GS39783 stimulate ERK1/2 signalling in cells lacking functional GABA
B
receptors
作者:
Maria C. Olianas
;
molianas@unica.it
;
Simona Dedoni
;
Pierluigi Onali
关键词:
CGP7930 (PubChem CID
;
5024764)
;
GS39783 (PubChem CID
;
6604928)
;
(-)-baclofen (PubChem CID
;
44602)
;
SKF97541 (PubChem CID
;
5230)
;
CGP55845 (PubChem CID
;
5311042)
;
CGP54626 (PubChem CID
;
197584)
;
phorbol 12-myristate 13 acetate (PubChem CID
;
27924)
;
Go 6850 (PubChem CID
;
2396)
;
5Z-7-oxozeaenol (PubChem CID
;
9863776)
;
GW5074 (PubChem CID
;
5924208)
刊名:European Journal of Pharmacology
出版年:2017
6.
Integrated regulation of AMPA glutamate receptor phosphorylation in the striatum by dopamine and acetylcholine
作者:
Bing Xue
a
;
Elton C. Chen
b
;
Nan He
a
;
Dao-Zhong Jin
a
;
Li-Min Mao
a
;
John Q. Wang
a
;
b
;
c
;
wangjq@umkc.edu" class="auth_mail" title="E-mail the corresponding author
关键词:
D1
;
D2
;
Muscarinic receptor
;
S845
;
Protein kinase A
;
Caudate putamen
;
Nucleus accumbens
;
Positive
allosteric
modulator
刊名:Neuropharmacology
出版年:2017
7.
Synthesis and evaluation of 1-(cyclopropylmethyl)-4-(4-[
11
C]methoxyphenyl)-piperidin-1-yl-2-oxo-1,2-dihydropyridine-3-carbonitrile ([
11
C]CMDC) for PET imaging of metabotropic glutamate receptor 2 in the rat brain
作者:
Yufei Ma
a
;
b
;
1
;
Katsushi Kumata
a
;
1
;
Joji Yui
a
;
Yiding Zhang
a
;
Tomoteru Yamasaki
a
;
Akiko Hatori
a
;
Masayuki Fujinaga
a
;
Nobuki Nengaki
a
;
Lin Xie
a
;
Hui Wang
b
;
Ming-Rong Zhang
a
;
zhang.ming-rong@qst.go.jp
关键词:
[11C]CMDC
;
In vitro autoradiography
;
Metabotropic glutamate receptor 2
;
Positron emission tomography
;
Radiotracer
;
Schizophrenia
刊名:Bioorganic & Medicinal Chemistry
出版年:2017
8.
(+)-and (−)-Phenazocine enantiomers: Evaluation of their dual opioid agonist/σ
1
antagonist properties and antinociceptive effects
关键词:
Sigma-1 receptor
;
(+)-Phenazocine
;
(&minus
;
)-Phenazocine
;
Mechanical antinociception
;
Bifunctional ligand
;
Opioid
刊名:European Journal of Medicinal Chemistry
出版年:2017
9.
Effects of alpha-7 nicotinic acetylcholine receptor
positive
allosteric
modulator
on lipopolysaccharide-induced neuroinflammatory pain in mice
作者:
Muzaffar Abbas
;
Shafiqur Rahman
;
shafiqur.rahman@sdstate.edu" class="auth_mail" title="E-mail the corresponding author
关键词:
Nicotinic receptor
;
Alpha- 7
positive
allosteric
modulator
;
Neuroinflammatory pain
;
Microglia
;
Hippocampus
;
Mice
刊名:European Journal of Pharmacology
出版年:2016
10.
In vitro and in vivo pharmacological characterization of SSD114, a novel GABAB
positive
allosteric
modulator
作者:
Alessandra Porcu
a
;
Carla Lobina
b
;
Daniela Giunta
c
;
Maurizio Solinas
c
;
Claudia Mugnaini
d
;
M. Paola Castelli
a
;
castelli@unica.it" class="auth_mail" title="E-mail the corresponding author
关键词:
GABAB receptors
;
Positive
allosteric
modulator
;
GTPγS binding
;
Baclofen-induced sedation/hypnosis
刊名:European Journal of Pharmacology
出版年:2016
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