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CNKI学位论文(14)
知网期刊论文(1)
在“
Elsevier电子期刊
”中,
命中:
11
条,耗时:0.0249877 秒
在所有数据库中总计命中:
15
条
1.
Identi
f
ication o
f
structure-activity relationships
f
or adverse e
ff
ects o
f
pharmaceuticals in humans: Part B. Use o
f
(Q)SAR systems
f
or early detection o
f
drug-induced hepatobiliary
and
urinary tract t
作者:
Edwin J. Matthews
;
Carling J. Ursem
;
Naomi L. Kruhlak
;
R.
Daniel
Benz
;
David Aragoné
;
s Sabaté
;
Chihae Yang
;
Gilles Klopman
;
Joseph
F
.
Contrera
关键词:
AERS
;
Computational toxicology
;
Drug adverse e
ff
ects
;
Drug-induced liver injury
;
Drug-induced renal toxicity
;
In silico
;
Post-market reporting
;
Quantitative structure-activity relationships
;
QSAR so
f
tware
;
SAR
;
SRS
刊名:Regulatory Toxicology
and
Pharmacology
出版年:2009
2.
Identi
f
ication o
f
structure–activity relationships
f
or adverse e
ff
ects o
f
pharmaceuticals in humans: Part C: Use o
f
QSAR
and
an expert system
f
or the estimation o
f
the mechanism o
f
action o
f
dr
作者:
Edwin J. Matthews
;
Naomi L. Kruhlak
;
R.
Daniel
Benz
;
David Aragoné
;
s Sabaté
;
Carol A. Marchant
;
Joseph
F
.
Contrera
关键词:
Adverse drug e
ff
ects
;
AERS
;
Clinical indication
;
Computational toxicology
;
Drug-induced kidney toxicity
;
Drug-induced liver toxicity
;
In silico
;
Mechanism o
f
action
;
Pharmaceutical patent
;
Post-market reporting
;
Quantitative structure–
;
activi
刊名:Regulatory Toxicology
and
Pharmacology
出版年:2009
3.
Identi
f
ication o
f
structure–activity relationships
f
or adverse e
ff
ects o
f
pharmaceuticals in humans. Part A: Use o
f
FDA post-market reports to create a database o
f
hepatobiliary
and
urinary tra
作者:
Carling J. Ursem
;
Naomi L. Kruhlak
;
Joseph
F
.
Contrera
;
Philip M. MacLaughlin
;
R.
Daniel
Benz
;
Edwin J. Matthews
关键词:
AERS
;
Drug-induced kidney toxicity
;
Drug-induced liver toxicity
;
Human adverse e
ff
ects
;
Post-market reporting
;
Quantitative structure–
;
activity relationships
;
QSAR
;
SRS
刊名:Regulatory Toxicology
and
Pharmacology
出版年:2009
4.
Comparison o
f
MC4PC
and
MDL-QSAR rodent carcinogenicity predictions
and
the enhancement o
f
predictive per
f
ormance by combining QSAR models
作者:
Joseph
F
.
Contrera
;
Naomi L. Kruhlak
;
Edwin J. Matthews
;
R.
Daniel
Benz
关键词:
Carcinogenicity
;
Discriminant analysis
;
In silico
;
Predictive toxicology
;
Topological descriptors
;
QSAR
;
E-state
;
Chemoin
f
ormatics
;
Discriminant analysis
;
Consensus prediction
刊名:Regulatory Toxicology
and
Pharmacology
出版年:2007
5.
A comprehensive model
f
or reproductive
and
developmental toxicity hazard identi
f
ication: II. Construction o
f
QSAR models to predict activities o
f
untested chemicals
作者:
Edwin J. Matthews
;
Naomi L. Kruhlak
;
R.
Daniel
Benz
;
Julian Ivanov
;
Gilles Klopman
;
Joseph
F
.
Contrera
关键词:
MC4PC
;
Computational toxicology
;
Developmental toxicity
;
Dysmorphogenesis
;
Predictive modeling
;
Quantitative structure activity relationships (QSAR)
;
Reproductive toxicity
;
Reprotox
;
Teratogenicity
;
Weight o
f
evidence
刊名:Regulatory Toxicology
and
Pharmacology
出版年:2007
6.
A comprehensive model
f
or reproductive
and
developmental toxicity hazard identi
f
ication: I. Development o
f
a weight o
f
evidence QSAR database
作者:
Edwin J. Matthews
;
Naomi L. Kruhlak
;
R.
Daniel
Benz
;
Joseph
F
.
Contrera
关键词:
Developmental toxicity
;
Dysmorphogenesis
;
Quantitative structure–
;
activity relationships
;
QSAR
;
Reproductive toxicity
;
Reprotox
;
Teratogenicity
;
Weight o
f
evidence
刊名:Regulatory Toxicology
and
Pharmacology
出版年:2007
7.
An analysis o
f
genetic toxicity, reproductive
and
developmental toxicity,
and
carcinogenicity data: II. Identi
f
ication o
f
genotoxicants, reprotoxicants,
and
carcinogens using in silico methods
作者:
Edwin J. Matthews
;
Naomi L. Kruhlak
;
Michael C. Cimino
;
R.
Daniel
Benz
and
Joseph
F
.
Contrera
关键词:
MC4PC
;
Computational toxicology
;
Quantitative structure–
;
activity relationships
;
Predictive modeling
;
Genetic toxicity
;
Genetox
;
Reproductive
and
developmental toxicity
;
Reprotox
;
Carcinogenicity
;
Rodent carcinogenicity bioassay
;
Surrogate
刊名:Regulatory Toxicology
and
Pharmacology
出版年:2006
8.
An analysis o
f
genetic toxicity, reproductive
and
developmental toxicity,
and
carcinogenicity data: I. Identi
f
ication o
f
carcinogens using surrogate endpoints
作者:
Edwin J. Matthews
;
Naomi L. Kruhlak
;
Michael C. Cimino
;
R.
Daniel
Benz
and
Joseph
F
.
Contrera
关键词:
Genetic toxicity
;
Genetox
;
Reproductive
and
developmental toxicity
;
Reprotox
;
Rodent carcinogenicity bioassay
;
Surrogate
;
Database
刊名:Regulatory Toxicology
and
Pharmacology
出版年:2006
9.
In silico screening o
f
chemicals
f
or bacterial mutagenicity using electrotopological E-state indices
and
MDL QSAR so
f
tware
作者:
Joseph
F
.
Contrera
;
Edwin J. Matthews
;
Naomi L. Kruhlak
and
R.
Daniel
Benz
关键词:
QSAR
;
E-state indices
;
Electrotopological
;
Mutagenicity
;
In silico screening
;
Predictive toxicology
;
Drug development
;
Salmonella
;
Setubal principles
刊名:Regulatory Toxicology
and
Pharmacology
出版年:2005
10.
Estimating the sa
f
e starting dose in phase I clinical trials
and
no observed e
ff
ect level based on QSAR modeling o
f
the human maximum recommended daily dose
作者:
Contrera
;
Joseph
F
.
;
Matthews
;
Edwin J.
;
Kruhlak
;
Naomi L.
;
Benz
;
R.
Daniel
关键词:
Quantitative structure activity relationship
;
Maximum recommended daily dose
;
Maximum recommended sa
f
e starting dose
;
E-state descriptors
;
Predictive modeling
;
Sa
f
ety
f
actors
;
In silico modeling
;
Phase 1 clinical trials
;
No observed adverse e
ff
ect level
刊名:Regulatory Toxicology
and
Pharmacology
出版年:2004
1
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