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在“Elsevier电子期刊”中，命中：991条，耗时：0.0349826 秒

在所有数据库中总计命中：1,344条

1.A PET study comparing receptor occupancy by five selective cannabinoid 1 receptor antagonists in non-human primates

作者：Stephan Hjorth^a ; ¹ ; Cecilia Karlsson^b ; ¹ ; ^{Cecilia.Karlsson@astrazeneca.com" class="auth_mail" title="E-mail the corresponding author} ; Aurelija Jucaite^c ; Katarina Varnä ; s^d ; Ulrika Wä ; hlby Hamré ; n^e ; Peter Johnströ ; m^c ; Balá ; zs Gulyá ; s^d ; Sean R. Donohue^f ; Victor W. Pike^f ; Christer Halldin^d ; Lars Farde^c

关键词：Cannabinoid 1 receptor (CB1R) antagonists ; Obesity ; Positron emission tomography (PET) ; Receptor occupancy ; [11C]SD5024 ; Rimonabant ; Taranabant

刊名：Neuropharmacology

出版年：2016

2.Prediction of CNS occupancy of dopamine D2 receptor based on systemic exposure and in vitro experiments

作者：Kayoko Kanamitsu^a ; ^b ; Ryosuke Arakawa^c ; Yuichi Sugiyama^d ; Tetsuya Suhara^c ; Hiroyuki Kusuhara^a ; ^{kusuhara@mol.f.u-tokyo.ac.jp}

关键词：Positron emission tomography ; Brain ; Central nervous system ; Human ; Receptor occupancy ; Dopamine D2 receptor ; Physiologically based pharmacokinetic model

刊名：Drug Metabolism and Pharmacokinetics

出版年：2016

3.Application of target-mediated drug disposition model to predict human pharmacokinetics and target occupancy of GC1118, an anti-epidermal growth factor receptor antibody

作者：Wan-Su Park¹ ; ² ; Seunghoon Han¹ ; ² ; Jongtae Lee¹ ; ² ; Taegon Hong³ ; Dong-Seok Yim¹ ; ²

刊名：Drug Metabolism and Pharmacokinetics

出版年：2017

4.Concerted action of histone methyltransferases G9a and PRMT-1 regulates PGC-1α-RIG-I axis in IFNγ treated glioma cells

作者：Ruchi Ghildiyal ; Ellora Sen ; ^{ellora@nbrc.ac.in}

关键词：IFNγ ; interferon gamma ; RIG-I ; retinoic acid (RA)-inducible gene-I ; SFM ; serum free media ; ChIP ; chromatin immunoprecipitation ; NFκB ; nuclear factor kappa B ; PGC-1α ; peroxisome proliferator-activated receptor gamma coactivator-1 alpha ; PRMT-1 ; protein arginine methyltransferase 1 ; MTS ; 3-(4 ; 5-dimethylthiazol-2-yl)-5-(3-carboxymethoxyphenyl)-2-(4-sulfophenyl)-2H-tetrazolium ; TUNEL ; terminal deoxynucleotidyl transferase dUTP nick end labeling

刊名：Cytokine

出版年：2017

5.Occupancy of pramipexole (Sifrol) at cerebral dopamine D2/3 receptors in Parkinson's disease patients

作者：Angela Deutschlä ; nder^a ; Christian la Fougè ; re^b ; Kai Boetzel^a ; Nathalie L. Albert^c ; Franz-Josef Gildehaus^c ; Peter Bartenstein^c ; Guoming Xiong^c ; Paul Cumming^d ; ^e ; ^{paul.cumming@qut.edu.au}

关键词：Parkinson's disease ; Pet ; Fallypride ; Pramipexole ; Agonist ; Dopamine receptors ; Occupancy

刊名：NeuroImage: Clinical

出版年：2016

6.The effects in rats of lisdexamfetamine in combination with olanzapine on mesocorticolimbic dopamine efflux, striatal dopamine D₂ receptor occupancy and stimulus generalization to a d-amphetamine cue

作者：Peter H. Hutson^a ; ^{phutson@shire.com" class="auth_mail" title="E-mail the corresponding author} ; Helen L. Rowley^b ; James Gosden^b ; Rajiv S. Kulkarni^b ; Nigel Slater^b ; Patrick L. Love^c ; Yiyun Wang^c ; David Heal^b

关键词：Lisdexamfetamine ; Prefrontal cortex ; Nucleus accumbens ; Dopamine efflux ; Dopamine D2 receptor occupancy ; Drug discrimination

刊名：Neuropharmacology

出版年：2016

7.A comparison of two semi-mechanistic models for prolactin release and prediction of receptor occupancy following administration of dopamine D₂ receptor antagonists in rats

作者：Amit Taneja^a ; ¹ ; An Vermeulen^b ; Dymphy R.H. Huntjens^b ; Meindert Danhof^c ; Elizabeth C.M. De Lange^c ; Johannes H. Proost^a ; ^{j.h.proost@rug.nl" class="auth_mail" title="E-mail the corresponding author}

关键词：Risperidone (PubChem CID ; 5073) ; Paliperidone (PubChem CID ; 115237) ; Remoxipride (PubChem CID ; 54477)

刊名：European Journal of Pharmacology

出版年：2016

8.N-phenylpropyl-N′-substituted piperazines occupy sigma receptors and alter methamphetamine-induced hyperactivity in mice

作者：Dennis K. Miller^a ; ^b ; ^{millerden@missouri.edu} ; Eric S. Park^b ; Susan Z. Lever^c ; ^d ; John R. Lever^e ; ^f

关键词：Behavior ; Methamphetamine ; Locomotor activity ; Mouse ; Dopamine transporter ; Receptor occupancy ; Sigma receptor

刊名：Pharmacology Biochemistry and Behavior

出版年：2016

9.Current drug treatments targeting dopamine D3 receptor

作者：Gian Marco Leggio ; Claudio Bucolo ; Chiara Bianca Maria Platania ; Salvatore Salomone ; ^{salomone@unict.it" class="auth_mail" title="E-mail the corresponding author} ; Filippo Drago

关键词：5-HT ; 5-hydroxytryptamine ; 7-OH-DPAT ; 7-hydroxy-N ; N-di-n-propyl-2-aminotetralin ; [11C]-(+)-PHNO ; [11C]-(+)-propyl-hexahydro-naphtho-oxazin ; AH ; aqueous humor ; BDNF ; Brain-Derived Neurotrophic Factor ; CNS ; central nervous system ; DA ; dopamine ; DR ; dopamine receptor ; D2LR ; dopamine receptor 2 long form splice variant ; D2SR ; dopamine receptor 2 short form splice variant ; D3R-/- ; dopamine receptor 3 null mice ; EMA ; European Medicines Agency ; FDA ; Food and Drug Administration ; IOP ; intraocular pressu

刊名：Pharmacology and Therapeutics

出版年：2016

10.BRET-based β-arrestin2 recruitment to the histamine H₁ receptor for investigating antihistamine binding kinetics

作者：Reggie Bosma ; Ryo Moritani ; Rob Leurs ; Henry F. Vischer ; ^{h.f.vischer@vu.nl" class="auth_mail" title="E-mail the corresponding author}

关键词：H1R ; histamine H1 receptor ; GPCR ; G protein-coupled receptor ; NFAT ; nuclear factor of activated T-cells ; ERK ; extracellular signal-regulated kinases ; BRET ; bioluminescence resonance energy transfer ; HEK293T ; Human embryonic kidney cells transformed with large T antigen ; PBZ ; phenoxybenzamine ; CTZ-h ; coelenterazine-h

刊名：Pharmacological Research

出版年：2016

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