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在“Elsevier电子期刊”中，命中：856条，耗时：0.0369602 秒

在所有数据库中总计命中：3,541条

1.Imidazo[1,2-a]pyrazin-8-amine core for the design of new adenosine receptor antagonists: Structural exploration to target the A₃ and A_2A subtypes

作者：Daniela Poli^a ; Matteo Falsini^a ; Flavia Varano^a ; Marco Betti^a ; Katia Varani^b ; Fabrizio Vincenzi^b ; Anna Maria Pugliese^c ; Felicita Pedata^c ; Diego Dal Ben^d ; Ajiroghene Thomas^d ; Ilaria Palchetti^e ; ^f ; Francesca Bettazzi^e ; Daniela Catarzi^a ; ^{daniela.catarzi@unifi.it} ; Vittoria Colotta^a

关键词：G protein-coupled receptors ; Adenosine receptor antagonists ; Imidazopyrazines ; Bicyclic heteroaromatic systems ; Ligand-receptor modeling studies

刊名：European Journal of Medicinal Chemistry

出版年：2017

2.The structure and function of glutamate receptors: Mg²⁺ block to X-ray diffraction

作者：Mark L. Mayer ^{mayerm@mail.nih.gov" class="auth_mail" title="E-mail the corresponding author}

关键词：Structural biology ; Glutamate receptors

刊名：Neuropharmacology

出版年：2017

3.Estrogen Receptor β as a Pharmaceutical Target

作者：Margaret Warner¹ ; Bo Huang¹ ; Jan-Ake Gustafsson¹ ; ² ; ^{jgustafs@Central.UH.EDU}

刊名：Trends in Pharmacological Sciences

出版年：2017

4.Polypharmacology of dopamine receptor ligands

作者：S. Butini^a ; K. Nikolic^b ; S. Kassel^c ; H. Brü ; ckmann^c ; S. Filipic^b ; D. Agbaba^b ; S. Gemma^a ; S. Brogi^a ; M. Brindisi^a ; G. Campiani^a ; H. Stark^c ; ^{stark@hhu.de" class="auth_mail" title="E-mail the corresponding author} ; ^{h.stark@zafes.de" class="auth_mail" title="E-mail the corresponding author}

关键词：ACh ; acetylcholine ; AC ; adenylyl cyclase ; APO ; apomorphine ; PD ; Parkinson&rsquo ; s disease ; CNS ; central nervous system ; COMT ; catecholamine O-methyl transferase ; DML ; designed multiple ligands ; L-DOPA ; L-3 ; 4-dihydroxyphenylalanine ; LID ; L-DOPA induced dyskinesia ; DAT ; dopamine reuptake transporter ; EPS ; extrapyramidal symptoms ; GABA ; γ-aminobutyric acid ; IBS ; imidazole binding site ; MAO ; monoamine oxidase ; NET ; norepinephrine reuptake transporter ; SERT ; serotonin reuptake transporter ; THPB ; tetr

刊名：Progress in Neurobiology

出版年：2016

5.A new, simple and robust radioligand binding method used to determine kinetic off-rate constants for unlabeled ligands. Application at α_2A- and α_2C-adrenoceptors

作者：Staffan Uhlé ; n^a ; ^b ; ^{staffan.uhlen@neuro.uu.se" class="auth_mail" title="E-mail the corresponding author} ; Helgi B. Schiö ; th^b ; Jan Anker Jahnsen^a

关键词：Spiroxatrine ; MK912 ; Off-rate ; Residence time ; [3H]-RX821002 ; Kinetics

刊名：European Journal of Pharmacology

出版年：2016

6.Characterization of PCS1055, a novel muscarinic M₄ receptor antagonist

作者：Carrie H. Croy^b ; Wai Y. Chan^a ; ¹ ; Andrea M. Castetter^b ; Marla L. Watt^b ; ² ; Anne T. Quets^b ; Christian C. Felder^b ; ^{Felder@lilly.com" class="auth_mail" title="E-mail the corresponding author}

关键词：Muscarinic M4 receptors ; Competitive antagonists ; PCS1055 ; Subtype selectivity

刊名：European Journal of Pharmacology

出版年：2016

7.Pharmacological stimulation of GAL₁R but not GAL₂R attenuates kainic acid-induced neuronal cell death in the rat hippocampus

作者：Kristin Webling^b ; ¹ ; ^{kristin.webling@neurochem.su.se" class="auth_mail" title="E-mail the corresponding author} ; Jessica L. Groves-Chapman^a ; ¹ ; Johan Runesson^b ; Indrek Saar^c ; Andreas Lang^d ; Rannar Sillard^b ; Erik Jakovenko^b ; Barbara Kofler^d ; Philip V. Holmes^a ; Ü ; lo Langel^b ; ^c

关键词：CHO cells ; Chinese hamster ovary cells ; DMEM ; Dulbecco's modified essential medium ; FBS ; fetal bovine serum ; GAL1R ; galanin receptor subtype 1 ; GAL2R ; galanin receptor subtype 2 ; GAL3R ; galanin receptor subtype 3 ; HEK cells ; human embryonic kidney cells ; KA ; kainic acid ; TFA ; trifluoroacetic acid

刊名：Neuropeptides

出版年：2016

8.New therapeutic opportunities for 5-HT_2C receptor ligands in neuropsychiatric disorders

作者：Giuseppe Di Giovanni^a ; ^b ; ^{giuseppe.digiovanni@um.edu.mt" class="auth_mail" title="E-mail the corresponding author} ; Philippe De Deurwaerdè ; re^c ; ^{deurwaer@u-bordeaux2.fr" class="auth_mail" title="E-mail the corresponding author}

关键词：5-HT receptors ; mRNA editing ; G protein coupled receptors ; Receptor oligomers ; Dopamine ; GABA

刊名：Pharmacology and Therapeutics

出版年：2016

9.Modification of the anabaseine pyridine nucleus allows achieving binding and functional selectivity for the α3β4 nicotinic acetylcholine receptor subtype

作者：Carlo Matera^a ; Marta Quadri^a ; Miriam Sciaccaluga^b ; Diego Yuri Pomè ; ^a ; Francesca Fasoli^d ; ^e ; Marco De Amici^a ; Sergio Fucile^b ; ^c ; Cecilia Gotti^d ; ^e ; Clelia Dallanoce^a ; ^{clelia.dallanoce@unimi.it" class="auth_mail" title="E-mail the corresponding author} ; Giovanni Grazioso^a

关键词：Neuronal nicotinic acetylcholine receptors ; Molecular modeling ; Design ; Anabaseine-related derivatives ; α3β4 nicotinic ligands ; Binding affinity ; Functional activity/selectivity

刊名：European Journal of Medicinal Chemistry

出版年：2016

10.Current drug treatments targeting dopamine D3 receptor

作者：Gian Marco Leggio ; Claudio Bucolo ; Chiara Bianca Maria Platania ; Salvatore Salomone ; ^{salomone@unict.it" class="auth_mail" title="E-mail the corresponding author} ; Filippo Drago

关键词：5-HT ; 5-hydroxytryptamine ; 7-OH-DPAT ; 7-hydroxy-N ; N-di-n-propyl-2-aminotetralin ; [11C]-(+)-PHNO ; [11C]-(+)-propyl-hexahydro-naphtho-oxazin ; AH ; aqueous humor ; BDNF ; Brain-Derived Neurotrophic Factor ; CNS ; central nervous system ; DA ; dopamine ; DR ; dopamine receptor ; D2LR ; dopamine receptor 2 long form splice variant ; D2SR ; dopamine receptor 2 short form splice variant ; D3R-/- ; dopamine receptor 3 null mice ; EMA ; European Medicines Agency ; FDA ; Food and Drug Administration ; IOP ; intraocular pressu

刊名：Pharmacology and Therapeutics

出版年：2016

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