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在“Elsevier电子期刊”中，命中：66条，耗时：0.0339842 秒

在所有数据库中总计命中：91条

1.Inhibition of mTOR/eIF4E by anti-viral drug ribavirin effectively enhances the effects of paclitaxel in oral tongue squamous cell carcinoma

作者：Dehua Dai¹ ; Hujie Chen¹ ; Jing Tang ; Yi Tang ; ^{365443309@qq.com}

关键词：Tongue squamous carcinoma ; Ribavirin ; eIF4E ; Drug repurposing

刊名：Biochemical and Biophysical Research Communications

出版年：2017

2.Using Big Data to Discover Diagnostics and Therapeutics for Gastrointestinal and Liver Diseases

作者：Benjamin Wooden¹ ; Nicolas Goossens¹ ; ² ; Yujin Hoshida¹ ; ^{yujin.hoshida@mssm.edu} ; Scott L. Friedman¹

关键词：Big Data ; Translational Bioinformatics ; Drug Repurposing ; Precision Medicine

刊名：Gastroenterology

出版年：2017

3.Exploring the potential of genome editing CRISPR-Cas9 technology

作者：Vijai Singh^a ; ^{vijaisingh15@gmail.com} ; ^{vijai.singh@issb.genopole.fr} ; Darren Braddick^a ; Pawan Kumar Dhar^b

关键词：Cas ; CRISPR-associated proteins ; cccDNA ; covalently closed circular DNA ; CCR5 ; C-C chemokine receptor type 5 ; CHO ; Chinese hamster ovary ; CRISPRs ; clustered regularly interspaced short palindromic repeats ; CRISPRa ; CRISPR activation ; CRISPRi ; CRISPR interference ; crRNAs ; CRISPR RNAs ; dCas9 ; dead Cas9 ; DMD ; Duchenne muscular dystrophy ; DSB ; double-strand break ; eGFP ; enhanced green fluorescent protein ; HDR ; homology-directed repair ; HEK 293 ; human embryonic kidney 293 ; Indel ; insertion and deleti

刊名：Gene

出版年：2017

4.Discovery of pyrazolopyrimidine derivatives as novel inhibitors of ataxia telangiectasia and rad3 related protein (ATR)

作者：Sreekanth A. Ramachandran^a ; Pradeep S. Jadhavar^a ; Manvendra P. Singh^a ; Ankesh Sharma^a ; Gaurav N. Bagle^a ; Kevin P. Quinn^b ; Po-yin Wong^b ; Andrew A. Protter^b ; ^c ; Roopa Rai^b ; Son M. Pham^b ; ; Jeffrey N. Lindquist^b ; ^{pham.sm@gmail.com}

关键词：ATR ; Pyrazolopyrimidine ; DNA damage ; PI3K ; HTS

刊名：Bioorganic & Medicinal Chemistry Letters

出版年：2017

5.Repurposing strategies for tropical disease drug discovery

作者：Dana M. Klug^a ; Michael H. Gelb^b ; Michael P. Pollastri^a ; ^{m.pollastri@neu.edu" class="auth_mail" title="E-mail the corresponding author}

关键词：Drug repurposing ; Target repurposing ; Lead repurposing ; Target class repurposing ; Neglected tropical disease ; Tropical disease ; Piggy-back drug discovery ; Drug repositioning

刊名：Bioorganic & Medicinal Chemistry Letters

出版年：2016

6.Repurposing Drugs to Target the Diabetes Epidemic

作者：Nigel Turner¹ ; Xiao-Yi Zeng² ; Brenna Osborne¹ ; Suzanne Rogers² ; ³ ; Ji-Ming Ye² ; ^{jiming.ye@rmit.edu.au" class="auth_mail" title="E-mail the corresponding author}

关键词：diabetes ; drug discovery ; alternative strategies

刊名：Trends in Pharmacological Sciences

出版年：2016

7.Leishmania donovani Aurora kinase: A promising therapeutic target against visceral leishmaniasis

作者：Rudra Chhajer^a ; Anirban Bhattacharyya^a ; Nicky Didwania^a ; Md Shadab^a ; Nirupam Das^b ; Partha Palit^b ; Tushar Vaidya^c ; Nahid Ali^a ; ^{nali@iicb.res.in" class="auth_mail" title="E-mail the corresponding author}

关键词：Aurora kinase ; Cytokinesis ; Hesperadin ; Therapeutic target ; Cell-cycle ; Leishmania donovani

刊名：Biochimica et Biophysica Acta (BBA) - General Subjects

出版年：2016

8.Sharpening nature's tools for efficient tuberculosis control: A review of the potential role and development of host-directed therapies and strategies for targeted respiratory delivery

作者：Gemma O'Connor^a ; ^b ; ^{gemmaoconnor@rcsi.ie" class="auth_mail" title="E-mail the corresponding author} ; Laura E. Gleeson^b ; ^{gleesole@tcd.ie" class="auth_mail" title="E-mail the corresponding author} ; Aidan Fagan-Murphy^a ; ^d ; ^{aidanfmurphy@rcsi.ie" class="auth_mail" title="E-mail the corresponding author} ; Sally-Ann Cryan^a ; ^c ; ^d ; ^{scryan@rcsi.ie" class="auth_mail" title="E-mail the corresponding author} ; Mary P. O'Sullivan^b ; ^{mary.osullivan@tcd.ie" class="auth_mail" title="E-mail the corresponding author} ; Joseph Keane^b ; ^{jkeane@stjames.ie" class="auth_mail" title="E-mail the corresponding author}

关键词：Ant-tubercular ; Immunomodulation ; Vitamin ; Targeted drug delivery ; Particle engineering ; Inhalation ; Adjunctive therapy ; Pre-clinical testing

刊名：Advanced Drug Delivery Reviews

出版年：2016

9.A perspective on genomic-guided anthelmintic discovery and repurposing using Haemonchus contortus

作者：Sarah Preston ; Abdul Jabbar ; Robin B. Gasser ; ^{robinbg@unimelb.edu.au" class="auth_mail" title="E-mail the corresponding author}

关键词：Parasitic nematode ; Drug resistance ; Genomics ; Transcriptomics ; Bioinformatics ; Whole-organism anthelmintic screening ; Drug discovery and repurposing

刊名：Infection, Genetics and Evolution

出版年：2016

10.Drug-repositioning opportunities for cancer therapy: novel molecular targets for known compounds

作者：Roberto Wü ; rth¹ ; Stefano Thellung¹ ; Adriana Bajetto¹ ; Michele Mazzanti² ; Tullio Florio¹ ; ³ ; Federica Barbieri¹ ; ³ ; ^{federica.barbieri@unige.it" class="auth_mail" title="E-mail the corresponding author}

刊名：Drug Discovery Today

出版年：2016

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