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内部出版物
在“
Elsevier电子期刊
”中,
命中:
14
条,耗时:小于0.01 秒
1.
Rational design, biophysical and biological characterization of site-specific antibody-
tubulysin
conjugates with improved stability, efficacy and pharmacokinetics
作者:
Pamela Thompson
a
;
1
;
Ryan Fleming
a
;
1
;
Binyam Bezabeh
a
;
Fengying Huang
a
;
Shenlan Mao
b
;
Cui Chen
b
;
Jay Harper
b
;
Haihong Zhong
b
;
Xizhe Gao
c
;
Xiang-Qing Yu
c
;
Mary Jane Hinrichs
d
;
Molly Reed
d
;
Adeela Kamal
b
;
2
;
Patrick Strout
b
;
Song Cho
b
;
Rob Woods
a
;
Robert E. Hollingsworth
b
;
Rakesh Dixit
d
;
Herren Wu
a
;
Changshou Gao
a
;
gaoc@medimmune.com" class="auth_mail" title="E-mail the corresponding author
;
Nazzareno Dimasi
a
;
dimasin@medimmune.com" class="auth_mail" title="E-mail the corresponding author
关键词:
Cysteine-engineered antibodies
;
Site-specific conjugation
;
Antibody-drug conjugates
;
In vivo efficacy
;
Tubulysin
;
Fc-gamma receptors
刊名:Journal of Controlled Release
出版年:2016
2.
Synthesis of stereochemically diverse cyclic analogs of
tubulysin
s
作者:
Yunjeong Park
a
;
Song Yi Bae
b
;
Jung-Mi Hah
c
;
Sang Kook Lee
b
;
sklee61@snu.ac.kr" class="auth_mail" title="E-mail the corresponding author
;
Jae-Sang Ryu
a
;
ryuj@ewha.ac.kr" class="auth_mail" title="E-mail the corresponding author
关键词:
Tubulysin
;
Antitumor agents
;
Peptides
;
Asymmetric catalysis
;
Hetero Diels&ndash
;
Alder reaction
刊名:Bioorganic & Medicinal Chemistry
出版年:2015
3.
363 An ongoing Phase 1 dose-escalation study of the folic acid-
tubulysin
small-molecule drug conjugate (SMDC) folate-
tubulysin
EC1456
刊名:European Journal of Cancer
出版年:2015
4.
Design, synthesis, and biological activities of triazole
tubulysin
V analogue
作者:
Xiudong Yang
a
;
Changming Dong
a
;
Jian Chen
a
;
Qi Liu
a
;
Bin Han
b
;
Quan Zhang
a
;
zhangquan612@163.com
;
Yue Chen
a
;
yuechen@nankai.edu.cn
关键词:
Synthesis
;
Tubulysin
;
Triazole
;
Click reaction
;
Biological activity
刊名:Tetrahedron Letters
出版年:2013
5.
Synthesis and cytotoxicity evaluation of diastereoisomers and N-terminal analogues of
tubulysin
-U
作者:
P. Sreejith Shankar
;
Serena Bigotti
;
Paolo Lazzari
;
Ilaria Manca
;
Marco Spiga
;
Monica Sani
;
Matteo Z
a
关键词:
Tubulysin
;
Diastereoisomers
;
Structure&ndash
;
activity-relationship
;
Cytotoxicity
;
Anti-cancer
刊名:Tetrahedron Letters
出版年:2013
6.
362 Phase 1 study of the PSMA-targeted
tubulysin
small-molecule drug conjugate EC1169 in patients with metastatic castrate-resistant prostate cancer (mCRPC)
刊名:European Journal of Cancer
出版年:2015
7.
Synthesis and biological evaluation of
tubulysin
D analogs related to stereoisomers of tubuvaline
作者:
Taku Shibue
;
Iwao Okamoto
;
Nobuyoshi Morita
;
Hiroshi Morita
;
Yusuke Hirasawa
;
Takahiro Hosoya
;
Osamu Tamura
关键词:
Tubulysin
D
;
Inhibition of tubulin polymerization
;
Antiproliferative activity
刊名:Bioorganic and Medicinal Chemistry Letters
出版年:2011
8.
Heterologous Expression and Genetic Engineering of the
Tubulysin
Biosynthetic Gene Cluster Using Red/ET Recombineering and Inactivation Mutagenesis
作者:
Yi Chai
1
;
4
;
Shiping Shan
1
;
3
;
4
;
Kira
;
J. Weissman
1
;
5
;
Shengbiao Hu
1
;
3
;
Youming Zhang
2
;
Rolf Mü
;
ller
1
;
rom@mx.uni-saarland.de
刊名:Chemistry & Biology
出版年:2012
9.
Acid mediated formation of an N-acyliminium ion from
tubulysin
s: A new methodology for the synthesis of natural
tubulysin
s and their analogs
作者:
Iontcho R.
;
Vlahov
;
;
;
ivlahov@endocyte.com
;
Yu
;
Wang
;
Marilynn
;
Vetzel
;
Spencer
;
Hahn
;
Paul J.
;
Kleindl
;
Joseph A.
;
Reddy
;
Christopher P.
;
Leamon
关键词:
Tubulysin
;
N
-Acyliminium ion
;
N
-Acyl-
N
;
O-acetals
;
N
-Acyl-
N
;
S-thioacetals
;
N
;
N&prime
;
-Diacyl-aminals
;
C&ndash
;
C bond formation
刊名:Bioorganic and Medicinal Chemistry Letters
出版年:2011
10.
Tubulysin
analogs incorporating desmethyl and dimethyl tubuphenylalanine derivatives
作者:
Ranganathan Balasubramanian
;
Bhooma Raghavan
;
Jaeson C. Steele
;
Dan L. Sackett
;
Robert A. Fecik
关键词:
Tubulysin
;
Tubulin
;
Anticancer agents
;
Cytotoxicity
;
Natural products
刊名:Bioorganic and Medicinal Chemistry Letters
出版年:2008
1
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