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内部出版物
CNKI学位论文(60)
知网期刊论文(9)
在“
Elsevier电子期刊
”中,
命中:
90
条,耗时:0.0109948 秒
在所有数据库中总计命中:
69
条
1.
Structure-activity relationship study of BACE1 inhibitors possessing a chelidonic or 2,6-pyridinedicarboxylic scaffold at the P
2
position
作者:
Yoshio Hamada
;
Kenji Suzuki
;
Tomoya Nakanishi
;
Diganta Sarma
;
Hiroko Ohta
;
Ryoji Yamaguchi
;
Moe Yamasaki
;
Koushi Hidaka
;
Shoichi Ishiura
;
Yoshiaki
Kiso
关键词:
Alzheimer&rsquo
;
s disease
;
尾-Secretase
;
BACE1
;
BACE1 inhibitor
刊名:Bioorganic and Medicinal Chemistry Letters
出版年:15 January, 2014
2.
A new class of aggregation inhibitor of amyloid-¦Â peptide based on an O-acyl isopeptide
作者:
Hiroyuki Kawashima
;
Youhei Sohma
;
Tomoya Nakanishi
;
Hitomi Kitamura
;
Hidehito Mukai
;
Masayuki Yamashita
;
Kenichi Akaji
;
Yoshiaki
Kiso
关键词:
A¦Â
;
amyloid ¦Â peptide
;
AD
;
Alzheimer&rsquo
;
s disease
;
DIC
;
N
;
N&prime
;
-diisopropylcarbodiimide
;
DMF
;
N
;
N-dimethylformamide
;
DMSO
;
dimethyl sulfoxide
;
FAM
;
carboxyfluorescein
;
HOBt
;
N-hydroxybenzotriazole
;
HPLC
;
high-performance liquid chromatography
;
kDa
刊名:Bioorganic and Medicinal Chemistry
出版年:2013
3.
Novel BACE1 inhibitors with a non-acidic heterocycle at the P
1
¡ä position
作者:
Kenji Suzuki
;
Yoshio Hamada
;
Jeffrey-Tri Nguyen
;
Yoshiaki
Kiso
关键词:
Non-acidic inhibitor
;
¦Â-Secretase
;
Alzheimer&rsquo
;
s disease
;
Quantitative structure&ndash
;
activity relationship
;
Hydroxymethylcarbonyl isostere
刊名:Bioorganic and Medicinal Chemistry
出版年:2013
4.
Design, synthesis, and biological evaluation of novel dipeptide-type SARS-CoV 3CL protease inhibitors: Structure-activity relationship study
作者:
Pillaiyar Thanigaimalai
;
Sho Konno
;
Takehito Yamamoto
;
Yuji Koiwai
;
Akihiro Taguchi
;
Kentaro Takayama
;
Fumika Yakushiji
;
Kenichi Akaji
;
Yoshiaki
Kiso
;
Yuko Kawasaki
;
Shen-En Chen
;
Aurash Naser-Tavakolian
;
Arne Sch?n
;
Ernesto Freire
;
Yoshio Hayashi
关键词:
SARS
;
SARS-CoV 3CL protease
;
Peptidomimetics
;
Dipeptide
;
Cysteine protease inhibitors
;
Docking study
刊名:European Journal of Medicinal Chemistry
出版年:2013
5.
Novel BACE1 inhibitors possessing a 5-nitroisophthalic scaffold at the P
2
position
作者:
Yoshio Hamada
;
Tomoya Nakanishi
;
Kenji Suzuki
;
Ryoji Yamaguchi
;
Takashi Hamada
;
Koushi Hidaka
;
Shoichi Ishiura
;
Yoshiaki
Kiso
关键词:
Alzheimer&rsquo
;
s disease
;
¦Â-Secretase
;
BACE1
;
BACE1 inhibitor
刊名:Bioorganic and Medicinal Chemistry Letters
出版年:2012
6.
Synthesis and structure-activity relationships of benzophenone-bearing diketopiperazine-type anti-microtubule agents
作者:
Yuri Yamazaki
;
Makiko Sumikura
;
Yurika Masuda
;
Yoshiki Hayashi
;
Hiroyuki Yasui
;
Yoshiaki
Kiso
;
Takumi Chinen
;
Takeo Usui
;
Fumika Yakushiji
;
Barbara Potts
;
Saskia Neuteboom
;
Michael Palladino
;
George Kenneth Lloyd
;
Yoshio Hayashi
关键词:
Anticancer drug
;
Benzophenone
;
Diketopiperazine
;
Microtubule depolymerizing activity
;
Vascular disrupting agent
刊名:Bioorganic and Medicinal Chemistry
出版年:2012
7.
Evaluation of dimerization-inhibitory activities of cyclic peptides containing a ¦Â-hairpin loop sequence of the EGF receptor
作者:
Takaaki Mizuguchi
;
Naho Ohara
;
Mika Iida
;
Ryunosuke Ninomiya
;
Shinji Wada
;
Yoshiaki
Kiso
;
Kazuki Saito
;
Kenichi Akaji
关键词:
EGF receptor
;
Dimerization
;
Inhibitor
;
Cyclic peptide
;
Retro-Inverso modification
;
A431 cell
刊名:Bioorganic and Medicinal Chemistry
出版年:2012
8.
Design and synthesis of several small-size HTLV-I protease inhibitors with different hydrophilicity profiles
作者:
Jeffrey-Tri Nguyen
a
;
Keiko Kato
a
;
Koushi Hidaka
a
;
Henri-Obadja Kumada
a
;
Tooru Kimura
a
;
Yoshiaki
Kiso
;
a
;
kiso
@mb.kyoto-phu.ac.jp
关键词:
Human T cell lymphotropic virus
;
HAM/TSP
;
Adult T cell leukemia
;
Aspartic protease
;
Inhibitor
刊名:Bioorganic and Medicinal Chemistry Letters
出版年:2011
9.
Maintaining potent HTLV-I protease inhibition without the P
3
-cap moiety in small tetrapeptidic inhibitors
作者:
Jeffrey-Tri Nguyen
a
;
Keiko Kato
a
;
Henri-Obadja Kumada
a
;
Koushi Hidaka
a
;
Tooru Kimura
a
;
Yoshiaki
Kiso
;
a
;
kiso
@mb.kyoto-phu.ac.jp
关键词:
Human T cell lymphotropic virus
;
Adult T cell leukemia
;
Aspartic protease
;
Inhibitor
;
Retrovirus
刊名:Bioorganic and Medicinal Chemistry Letters
出版年:2011
10.
‘Click peptide’ using production of monomer Aβ from the O-acyl isopeptide: Application to assay system of aggregation inhibitors and cellular cytotoxicity
作者:
Youhei Sohma
;
a
;
ysohma@mb.kyoto-phu.ac.jp
;
Yuta Hirayama
a
;
Atsuhiko Taniguchi
a
;
Hidehito Mukai
a
;
Yoshiaki
Kiso
;
a
;
kiso
@mb.kyoto-phu.ac.jp
关键词:
Aggregation
;
Amyloid
;
Alzheimer
;
Click peptide
;
Inhibitor
;
Isopeptide
刊名:Bioorganic and Medicinal Chemistry
出版年:2011
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