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CNKI学位论文(1)
在“
Elsevier电子期刊
”中,
命中:
8
条,耗时:小于0.01 秒
在所有数据库中总计命中:
1
条
1.
Driving external che
m
istry opti
m
ization via operations
m
anage
m
ent principles
作者:
F. Christopher Bi
1
;
Heather N. Frost
2
;
heather.n.frost@pfizer.co
m
" class="auth_
m
ail
;
Xiaolan Ling
3
;
David A. Perry
2
;
Sylvie K. Sakata
1
;
Si
m
on Bailey
4
;
Yvette
M
.
Fobian
5
;
Leslie Sloan
6
;
Anthony Wood
7
刊名:Drug Discovery Today
出版年:
M
arch, 2014
2.
Discovery and SAR of PF-4693627, a potent, selective and orally bioavailable
m
PGES-1 inhibitor for the potential treat
m
ent of infla
mm
ation
作者:
Graciela B. Arhancet
;
graciela.arhancet@novusint.co
m
;
Daniel P. Walker
;
Sue
M
etz
;
Yvette
M
.
Fobian
;
Steven E. Heasley
;
Jeffrey S. Carter
;
John R. Springer
;
Darin E. Jones
;
M
ichael J. Hayes
;
Alexander F. Shaffer
;
Gina
M
. Jero
m
e
;
M
ichael T. Baratta
;
Ben Zweifel
;
Willia
m
M. Moore
;
Jai
m
e L. Masferrer
;
M
ichael L. Vazquez
关键词:
Infla
mm
ation
;
m
-PGES-1
;
Benzoxazole
;
Clinical candidate
;
PF-4693627
刊名:Bioorganic and
M
edicinal Che
m
istry Letters
出版年:2013
3.
Synthesis and biological evaluation of substituted benzoxazoles as inhibitors of
m
PGES-1: Use of a confor
m
ation-based hypothesis to facilitate co
m
pound design
作者:
Daniel P. Walker
;
dpwalker@kalexsyn.co
m
;
quassinoid@earthlink.net
;
Graciela B. Arhancet
;
Hwang-Fun Lu
;
Steven E. Heasley
;
Sue
M
etz
;
Natasha
M
. Kablaoui
;
Francisco
M
. Franco
;
Cathleen E. Hanau
;
Jeffrey A. Scholten
;
John R. Springer
;
Yvette
M
.
Fobian
;
Jeffrey S. Carter
;
Li Xing
;
Shengtian Yang
;
Alexander F. Shaffer
;
Gina
M
. Jero
m
e
;
M
ichael T. Baratta
;
Willia
m
M. Moore
;
M
ichael L. Vazquez
关键词:
m
PGES-1
;
Benzoxazole
;
Solubility
;
Acyl glucuronide
;
Confor
m
ational analysis
刊名:Bioorganic and
M
edicinal Che
m
istry Letters
出版年:2013
4.
Investigation of a
m
inopyridiopyrazinones as PDE5 inhibitors: Evaluation of
m
odifications to the central ring syste
m
作者:
Robert O. Hughes
;
John K. Walker
;
Jerry W. Cubbage
;
Yvette
M
.
Fobian
;
D. Joseph Rogier
;
Steve E. Heasley
;
Rhadika
M
. Blevis-Bal
;
Alan G. Benson
;
Dafydd R. Owen
;
E. Jon Jacobsen
;
John N. Freskos
;
John
关键词:
PDE5
;
Pi–
;
pi interaction
;
A
m
inopyrazinone
;
Lead opti
m
ization
刊名:Bioorganic and
M
edicinal Che
m
istry Letters
出版年:2009
5.
Opti
m
ization of the a
m
inopyridopyrazinones class of PDE5 inhibitors: Discovery of 3-[(trans
作者:
Robert O. Hughes
;
John K. Walker
;
D. Joseph Rogier
;
Steve E. Heasley
;
Rhadika
M
. Blevis-Bal
;
Alan G. Benson
;
E. Jon Jacobsen
;
Jerry W. Cubbage
;
Yvette
M
.
Fobian
;
Dafydd R. Owen
;
John N. Freskos
;
John
关键词:
PDE5
;
A
m
inopyrazinone
;
Phar
m
acokinetics
刊名:Bioorganic and
M
edicinal Che
m
istry Letters
出版年:2009
6.
Physioche
m
ical drug properties associated with in vivo toxicological outco
m
es
作者:
Jason D. Hughes
;
Julian Blagg
;
David A. Price
;
Si
m
on Bailey
;
Gary A. DeCrescenzo
;
Rajesh V. Devraj
;
Ed
m
und Ellsworth
;
Yvette
M
.
Fobian
;
M
ichael E. Gibbs
;
Richard W. Gilles
;
Nigel Greene
;
Enoch Huang
关键词:
Toxicity
;
Polar surface area
;
C
log
P
;
Adverse events
刊名:Bioorganic and
M
edicinal Che
m
istry Letters
出版年:2008
7.
Confor
m
ational probes for elucidating the nature of substance P binding to the NK
1
receptor: initial efforts to
m
ap the Phe
7
-Phe
8
region
作者:
Yunsong
;
Tong
;
Fobian
;
Yvette
M
.
;
Wu
;
M
eiye
;
Boyd
;
Nor
m
an D.
;
M
oeller
;
Kevin D.
刊名:Bioorganic and
M
edicinal Che
m
istry Letters
出版年:1998
8.
New routes to confor
m
ationally restricted peptide building blocks: a convenient preparation of bicyclic piperazinone derivatives
作者:
Fobian
;
Yvette
M
.
;
d'Avignon
;
D. André
;
M
oeller
;
Kevin D.
刊名:Bioorganic and
M
edicinal Che
m
istry Letters
出版年:1996
1
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