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内部出版物
在“
Elsevier电子期刊
”中,
命中:
19,317
条,耗时:小于0.01 秒
1.
Novel 5-nitropyrimidine derivatives bearing endo-azabicyclic alcohols/amines as potent GPR119
agonists
关键词:
GPR119
agonists
;
5-Nitropyrimidine
;
endo-Azabicyclic alcohol
;
Full
agonists
刊名:Bioorganic & Medicinal Chemistry
出版年:2017
2.
LXR
agonists
promote the proliferation of neural progenitor cells through MEK-ERK pathway
作者:
Jing-zhong Wang
;
jingzhongwang1@sina.cn
;
Yan Fang
;
Wei-dong Ji
;
Hui Xu
关键词:
Neural progenitor cells
;
Proliferation
;
LXR
agonists
;
GW3965
;
LXR623
刊名:Biochemical and Biophysical Research Communications
出版年:2017
3.
Polar aromatic periphery increases agonist potency of spirocyclic free fatty acid receptor (GPR40)
agonists
inspired by LY2881835
作者:
Mikhail Krasavin
a
;
m.krasavin@spbu.ru
;
Alexey Lukin
b
;
Daria Bagnyukova
b
;
Nikolay Zhurilo
b
;
Aleksei Golovanov
b
;
Sergey Zozulya
c
;
d
;
Ihor Zahanich
c
;
Daniel Moore
e
;
Irina G. Tikhonova
e
关键词:
Drug discovery
;
FFA1
agonists
;
Antidiabetic agents
;
Spirocyclic motifs
;
Hydrophobic interactions
;
π&minus
;
π stacking
刊名:European Journal of Medicinal Chemistry
出版年:2017
4.
Novel biguanide-based derivatives scouted as TAAR1
agonists
: Synthesis, biological evaluation, ADME prediction and molecular docking studies
作者:
Michele Tonelli
a
;
michele.tonelli@unige.it
;
Stefano Espinoza
b
;
Raul R. Gainetdinov
c
;
d
;
Elena Cichero
a
;
cichero@unige.it
关键词:
Trace amine-associated receptors (TAARs)
;
Murine and human TAAR1
agonists
;
Phenyl biguanide derivatives
;
Benzyl biguanide derivatives
刊名:European Journal of Medicinal Chemistry
出版年:2017
5.
Synthesis of novel steroidal
agonists
, partial
agonists
, and ant
agonists
for the glucocorticoid receptor
作者:
Zhuang Jin
a
;
Hua Lin
a
;
Sathish Srinivasan
b
;
Jerome C. Nwachukwu
b
;
Nelson Bruno
b
;
Patrick R. Griffin
a
;
Kendall W. Nettles
b
;
;
Theodore M. Kamenecka
a
;
kameneck@scripps.edu
关键词:
AF-1
;
activation function-1
;
AF-2
;
activation function-2
;
AP-1
;
activator protein 1
;
dppp
;
1
;
3-bis(diphenylphosphino)propane
;
DEX
;
dexamethasone
;
DIEA
;
N
;
N-diisopropylethylamine
;
FKBP5
;
FK506-binding protein 5
;
GR
;
glucocorticoid receptor
;
GRE
;
glucocorticoid-response element
;
HATU
;
1-[bis(dimethylamino)methylene]-1H-1
2 ;
3-triazolo[4
;
5-b]pyridinium 3-oxid hexafluorophosphate
;
IL-6
;
Interleukin-6
;
LBD
;
ligand-binding domain
;
LPS
;
lipopolysaccharide
;
MMTV
;
mouse mammary tumor virus
;
NF-κB
;
nuclear
刊名:Bioorganic & Medicinal Chemistry Letters
出版年:2017
6.
Association of the DRD2 CA
n
-STR and DRD3 Ser9Gly polymorphisms with Parkinson's disease and response to dopamine
agonists
作者:
Shaoqing Xu
;
Jiujiang Liu
;
Xiaodong Yang
;
Yiwei Qian
;
Qin Xiao
;
xiaoqin67@medmail.com.cn
关键词:
DRD2 CAn-STR
;
DRD3 Ser9Gly
;
Parkinson's disease
;
Dopamine
agonists
刊名:Journal of the Neurological Sciences
出版年:2017
7.
A comparison of vasodilation mode among selexipag (NS-304; [2-{4-[(5,6-diphenylpyrazin-2-yl)(isopropyl)amino]butoxy}-N-(methylsulfonyl)acetamide]), its active metabolite MRE-269 and various prostacyclin receptor
agonists
in rat, porcine and human pulmonary arteries
作者:
Chiaki Fuchikami
a
;
c.fuchikami@po.nippon-shinyaku.co.jp
;
Kohji Murakami
a
;
Koyuki Tajima
a
;
Junko Homan
a
;
b
;
Keiji Kosugi
a
;
Kazuya Kuramoto
a
;
Michiko Oka
a
;
Keiichi Kuwano
b
关键词:
Pulmonary arterial hypertension
;
NS-304
;
Selexipag
;
MRE-269
;
Prostacyclin receptor
;
Human
刊名:European Journal of Pharmacology
出版年:2017
8.
Inverse
agonists
- What do they mean for psychiatry?
作者:
David Nutt
a
;
d.nutt@imperial.ac.uk
;
Stephen Stahl
b
;
Pierre Blier
c
;
Filippo Drago
d
;
Joseph Zohar
e
;
Sue Wilson
a
关键词:
Inverse agonist
;
Antagonist
;
Serotonin
;
5-HT2A
刊名:European Neuropsychopharmacology
出版年:2017
9.
Cytokine IL-10, activators of PI3-kinase,
agonists
of α-2 adrenoreceptor and antioxidants prevent ischemia-induced cell death in rat hippocampal cultures
作者:
Egor A. Turovsky
;
Maria V. Turovskaya
;
Sergei G. Gaidin
;
Valery P. Zinchenko
;
vpz@mail.ru
关键词:
Ischemia
;
OGD
;
Interleukin-10
;
PI3-Kinase
;
Alpha-2 adrenoreceptor
;
Antioxidant enzyme
;
Neuroprotective agents
;
Hippocampal cell culture
;
Global [Ca2+]i increase
;
Fura-2
;
Ca2+ imaging
;
Cell survival
刊名:Archives of Biochemistry and Biophysics
出版年:2017
10.
Characterization of P2X4 receptor
agonists
and ant
agonists
by calcium influx and radioligand binding studies
作者:
Aliaa Abdelrahman
a
;
Vigneshwaran Namasivayam
a
;
c
;
Sonja Hinz
a
;
Anke C. Schiedel
a
;
Meryem Kö
;
se
a
;
Maggi Burton
b
;
Ali El-Tayeb
a
;
1
;
Michel Gillard
b
;
Jü
;
rgen Bajorath
c
;
Marc de Ryck
b
;
Christa E. Mü
;
ller
a
;
christa.mueller@uni-bonn.de
关键词:
Ap3A
;
diadenosine triphosphate
;
Ap4A
;
diadenosine tetraphosphate
;
Ap5A
;
diadenosine pentaphosphate
;
AR-C67085MX
;
2-propylthio-β
;
γ-dichloromethylene-ATP
;
PSB0412
;
2-propargylthio-β
;
γ-dichloromethylene-ATP
;
5-BDBD
;
5-(3-bromophenyl)-1
;
3-dihydro-2H-benzofuro[3
;
2-e]-1
;
4-diazepin-2-one
;
BzATP
;
2&prime
;
(3&prime
;
)-O-(4-benzoylbenzoyl)adenosine 5&prime
;
-triphosphate
;
CHO-K1 cells
;
Chinese hamster ovary cells
;
HBSS
;
Hank&rsquo
;
s balanced salt solution
;
HEPES
;
4-(2-hydroxyethyl)-1-piperazine ethanesulfoni
刊名:Biochemical Pharmacology
出版年:2017
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