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内部出版物
CNKI学位论文(56)
知网期刊论文(7)
在“
Elsevier电子期刊
”中,
命中:
22
条,耗时:0.0359527 秒
在所有数据库中总计命中:
63
条
1.
Discovery of novel 5,6,7,8-tetrahydro[1,2,4]triazolo[4,3-a]pyridine derivatives as γ-secretase modulators (Part 2)
作者:
Takafumi Takai
;
takafumi.takai@takeda.com" class="auth_mail" title="E-mail the corresponding author
;
Tatsuki Koike
;
Minoru Nakamura
;
Yuichi Kajita
;
Toshiro Yamashita
;
Naohiro Taya
;
Tetsuya Tsukamoto
;
Tomomichi Watanabe
;
Koji Murakami
;
Tomoko Igari
;
Makoto Kamata
关键词:
GSM
;
γ-secretase modulator
;
Aβ
;
amyloid beta
;
AD
;
Alzheimer&rsquo
;
s disease
;
LLE
;
ligand
-
lipophilicity
efficiency
;
NORT
;
novel object recognition test
;
APP
;
amyloid precursor protein
;
MLM
;
mice liver microsomes
;
CNS
;
central nervous system
;
WT
;
wild type
刊名:Bioorganic & Medicinal Chemistry
出版年:2016
2.
Ensemble docking-based virtual screening yields novel spirocyclic JAK1 inhibitors
作者:
Dá
;
vid Bajusz
;
Gyö
;
rgy G. Ferenczy
;
Gyö
;
rgy M. Keserű
;
keseru.gyorgy@ttk.mta.hu
关键词:
AUC
;
area under the (ROC) curve
;
EF
;
enrichment factor
;
FDA
;
Food and Drug Administration
;
FPR
;
false positive rate
;
HTVS
;
high throughput virtual screening
;
JAK
;
Janus kinase
;
LLE
;
lipophilic
ligand
efficiency
;
LELP
;
lipophilicity
-corrected
ligand
efficiency
;
PME
;
particle mesh Ewald [method]
;
ROC
;
receiver operating characteristic [curve]
;
SP
;
standard precision
;
STAT
;
signal transducers and activators of transcription
;
TPR
;
true positive rate
刊名:Journal of Molecular Graphics and Modelling
出版年:2016
3.
Molecular inflation, attrition and the rule of five
作者:
Paul D. Leeson
leesonpd@gmail.com" class="auth_mail" title="E-mail the corresponding author
关键词:
Telaprevir (3010818)
;
Lapatinib (208908)
;
Ponatinib (24826799)
;
Bedaquiline (5388906)
;
Torcetrapib (159325)
;
Dalcetrapib (6918540)
;
Evacetrapib (49836058)
;
Anaceptrapib (11556427)
刊名:Advanced Drug Delivery Reviews
出版年:2016
4.
Design, synthesis and biological activity of phenoxyacetic acid derivatives as novel free fatty acid receptor 1 agonists
作者:
Zheng Li
a
;
Xuekun Wang
a
;
b
;
Xue Xu
c
;
Jianyong Yang
a
;
Wenting Xia
a
;
Xianhao Zhou
a
;
Wenlong Huang
a
;
d
;
ydhuangwenlong@126.com" class="auth_mail" title="E-mail the corresponding author
;
Hai Qian
a
;
d
;
qianhai24@163.com" class="auth_mail" title="E-mail the corresponding author
关键词:
FFA1 agonist
;
Phenoxyacetic acid
;
Ligand
efficiency
;
Type 2 diabetes
;
Hypoglycemia
刊名:Bioorganic & Medicinal Chemistry
出版年:2015
5.
Design, synthesis and structure-activity relationship studies of novel phenoxyacetamide-based free fatty acid receptor 1 agonists for the treatment of type 2 diabetes
作者:
Zheng Li
a
;
Xuekun Wang
a
;
Xue Xu
b
;
Jianyong Yang
a
;
Qianqian Qiu
a
;
Hao Qiang
a
;
Wenlong Huang
a
;
c
;
ydhuangwenlong@126.com" class="auth_mail" title="E-mail the corresponding author
;
Hai Qian
a
;
c
;
qianhai24@163.com" class="auth_mail" title="E-mail the corresponding author
关键词:
FFA1 agonist
;
OGTT
;
Amide linkers
;
Ligand
efficiency
;
Type 2 diabetes
刊名:Bioorganic & Medicinal Chemistry
出版年:2015
6.
Investigation of the influence of molecular topology on
ligand
binding
作者:
Rurika Oka
a
;
b
;
Ola Engkvist
b
;
Hongming Chen
b
;
hongming.chen@astrazeneca.com
关键词:
Ligand
efficiency
(LE)
;
Ligand
lipophilic
efficiency
(LLE)
;
Ligand
-
efficiency
-dependent
lipophilicity
(LELP)
;
Molecular topology class
刊名:Journal of Molecular Graphics and Modelling
出版年:2013
7.
[
18
F]-(fluoromethoxy)ethoxy)methyl)-1H-1,2,3-triazol-1-yl)propan-2-ol ([
18
F FPTC) a novel PET-
ligand
for cerebral beta-adrenoceptors
作者:
Leila Mirfeizi
;
Anna A. Rybczynska
;
Aren van Waarde
;
Lachlan Campbell-Verduyn
;
Ben L. Feringa
;
Rudi A.J.O. Dierckx
;
Philip H. Elsinga
关键词:
Click chemistry
;
[18
;
F]FPTC
;
尾-AR
刊名:Nuclear Medicine and Biology
出版年:February, 2014
8.
Discovery of a novel series of indoline carbamate and indolinylpyrimidine derivatives as potent GPR119 agonists
作者:
Kenjiro Sato
;
kenjirou.satou@takeda.com" class="auth_mail
;
Hiromichi Sugimoto
;
Kentaro Rikimaru
;
Hiroshi Imoto
;
Masahiro Kamaura
;
Nobuyuki Negoro
;
Yoshiyuki Tsujihata
;
Hirohisa Miyashita
;
Tomoyuki Odani
;
Toshiki Murata
关键词:
T2DM
;
type 2 diabetes mellitus
;
GLP-1
;
glucagon-like peptide-1
;
LLE
;
ligand
lipophilicity
efficiency
;
HBA
;
hydrogen bond acceptor
;
OGTT
;
oral glucose tolerance test
刊名:Bioorganic and Medicinal Chemistry
出版年:1 March, 2014
9.
Naphthyridinone (NTD) integrase inhibitors 4. Investigating N1 acetamide substituent effects with C3 amide groups
作者:
Brian A. Johns
a
;
brian.a.johns@gsk.com" class="auth_mail
;
Takashi Kawasuji
b
;
Jason G. Weatherhead
a
;
Eric E. Boros
a
;
James B. Thompson
a
;
Cecilia S. Koble
a
;
Edward P. Garvey
a
;
&dagger
;
;
Scott A. Foster
a
;
&Dagger
;
;
Jerry L. Jeffrey
a
;
Tamio Fujiwara
b
关键词:
Naphthyridinone
;
Integrase
;
HIV-1
刊名:Bioorganic and Medicinal Chemistry Letters
出版年:15 July 2014
10.
Molecular design, synthesis and biological evaluation of 1,4-dihydro-4-oxoquinoline ribonucleosides as TcGAPDH inhibitors with trypanocidal activity
作者:
Fabyana A. Soares
;
Renata Sesti-Costa
;
Jo?o Santana da Silva
;
Maria Cec¨ªlia B.V. de Souza
;
Vitor F. Ferreira
;
Fern
;
a da C. Santos
;
Patricia A.U. Monteiro
;
Andrei Leit?o
;
Carlos A. Montanari
关键词:
Chagas disease
;
Trypanosoma cruzi
;
GAPDH
;
Isothermal titration calorimetry
刊名:Bioorganic and Medicinal Chemistry Letters
出版年:2013
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