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在“Elsevier电子期刊”中，命中：312条，耗时：0.0869408 秒

在所有数据库中总计命中：3,015条

1.Comparison of BALB/c and CBA/J mice for the local lymph node assay using bromodeoxyuridine with flow cytometry (LLNA: BrdU-FCM)

作者：Yong Sun Lee^a ; Jung-Sun Yi^a ; Souk Jin Seo^a ; Joo Hwan Kim^a ; Mi-Sook Jung^b ; Im-Kwon Seo^b ; Ilyoung Ahn^a ; Kyungyuk Ko^a ; Tae Sung Kim^a ; Kyung Min Lim^c ; Soojung Sohn^a ; ^{sjsohn@korea.kr}

关键词：Local lymph node assay ; LLNA ; BrdU-FCM ; Skin sensitization ; BALB/c ; CBA/J ; Flow cytometry

刊名：Regulatory Toxicology and Pharmacology

出版年：2017

2.Chemical photoallergy: photobiochemical mechanisms, classification, and risk assessments

作者：Satomi Onoue^a ; ^{onoue@u-shizuoka-ken.ac.jp}Author Vitae ; Yoshiki Seto^a ; Hideyuki Sato^a ; Hayato Nishida^b ; Morihiko Hirota^b ; Takao Ashikaga^b ; Anne Marie Api^c ; David Basketter^d ; Yoshiki Tokura^e

关键词：3T3 NRU PT ; 3T3 neutral red uptake phototoxicity testing ; AOP ; adverse outcome pathway ; DEREK ; deductive estimation of risk from existing knowledge ; HOMO-LUMO gap ; energy gap between the highest occupied molecular orbital and the lowest unoccupied molecular orbital ; ICH ; International Council for Harmonization of Technical Requirements for Pharmaceuticals for human use ; IFRA ; International Fragrance Association ; LLNA ; local lymph node assay ; MEC ; molar extinction coefficient ; mROS assay ; micella

刊名：Journal of Dermatological Science

出版年：2017

3.Toxicity evaluation of the photoprotective compound LQFM048: Eye irritation, skin toxicity and genotoxic endpoints

作者：Renato Ivan de Á ; vila^a ; ¹ ; Marcelo de Sousa Vieira^a ; ¹ ; Marilisa Pedroso Nogueira Gaeti^b ; Larissa Cleres Moreira^a ; Laí ; s de Brito Rodrigues^a ; Gisele Augusto Rodrigues de Oliveira^a ; Aline Carvalho Batista^c ; Daniela Cristina Vinhal^d ; Ricardo Menegatti^d ; Marize Campos Valadares^a ; ^{marizeufg@gmail.com}

关键词：Alternative methods ; Eye irritation ; Genotoxicity ; Heterocyclic derivative ; Phototoxicity ; Skin sensitization

刊名：Toxicology

出版年：2017

4.Predictive capacity of a non-radioisotopic local lymph node assay using flow cytometry, LLNA:BrdU-FCM: Comparison of a cutoff approach and inferential statistics

作者：Da-eun Kim^a ; ¹ ; Hyeri Yang^a ; ¹ ; Won-Hee Jang^b ; Kyoung-Mi Jung^b ; Miyoung Park^b ; Jin Kyu Choi^b ; Mi-Sook Jung^c ; Eun-Young Jeon^c ; Yong Heo^d ; Kyung-Wook Yeo^d ; Ji-Hoon Jo^d ; Jung Eun Park^d ; Soo Jung Sohn^e ; Tae Sung Kim^e ; Il Young Ahn^e ; Tae-Cheon Jeong^f ; Kyung-Min Lim^a ; ^{kmlim@ewha.ac.kr" class="auth_mail" title="E-mail the corresponding author} ; SeungJin Bae^a ; ^{sjbae@ewha.ac.kr" class="auth_mail" title="E-mail the corresponding author}

关键词：Local lymph node assay ; LLNA ; BrdU&ndash ; FCM ; Prediction model ; Skin sensitization ; Predictive capacity ; Descriptive and inferential statistics

刊名：Journal of Pharmacological and Toxicological Methods

出版年：2016

5.Performance standard-based validation study for local lymph node assay: 5-bromo-2-deoxyuridine-flow cytometry method

作者：Ilyoung Ahn^a ; Tae-Sung Kim^a ; Eun-Sun Jung^b ; Jung-Sun Yi^b ; Won-Hee Jang^c ; Kyoung-Mi Jung^c ; Miyoung Park^c ; Mi-Sook Jung^d ; Eun-Young Jeon^d ; Kyeong-uk Yeo^e ; Ji-Hoon Jo^e ; Jung-Eun Park^e ; Chang-Yul Kim^e ; Yeong-Chul Park^e ; Won-Keun Seong^a ; Ai-Young Lee^f ; Young Jin Chun^g ; Tae Cheon Jeong^h ; Eui Bae Jeungⁱ ; Kyung-Min Lim^j ; SeungJin Bae^j ; Soojung Sohn^a ; Yong Heo^e ; ^{yheo@cu.ac.kr" class="auth_mail" title="E-mail the corresponding author}

关键词：Performance standards ; Validation study ; Local lymph node assay ; LLNA ; BrdU-FCM ; Skin sensitization ; Flow cytometry

刊名：Regulatory Toxicology and Pharmacology

出版年：2016

6.Lack of TAK1 in dendritic cells inhibits the contact hypersensitivity response induced by trichloroethylene in local lymph node assay

作者：Pan Yao ; Chu Hongqian ; Meng Qinghe ; Shang Lanqin ; Jiang Jianjun ; Yang Xiaohua ; Wei Xuetao ; Hao Weidong ; ^{whao@bjmu.edu.cn" class="auth_mail" title="E-mail the corresponding author}

关键词：TCE ; trichloroethylene ; CHS ; contact hypersensitivity ; TAK1 ; transforming growth factor-β activated kinase-1 ; DC ; dendritic cell ; LLNA ; local lymph node assay ; ACD ; allergic contact dermatitis ; DNFB ; 2 ; 4-dinirofluorobenzene

刊名：Toxicology and Applied Pharmacology

出版年：2016

7.Chemical applicability domain of the Local Lymph Node Assay (LLNA) for skin sensitisation potency. Part 2. The biological variability of the murine Local Lymph Node Assay (LLNA) for skin sensitisation

作者：David W. Roberts^a ; ^{D.W.Roberts@ljmu.ac.uk" class="auth_mail" title="E-mail the corresponding author} ; Anne Marie Api^b ; Aynur O. Aptula^c

关键词：LLNA ; Biological variability ; Non-animal prediction ; QMM

刊名：Regulatory Toxicology and Pharmacology

出版年：2016

8.Reactivity measurement in estimation of benzoquinone and benzoquinone derivatives’ allergenicity

作者：Wilbes Mbiya^a ; ^{wilbesm@gmail.com" class="auth_mail" title="E-mail the corresponding author} ; ^{mbiya@ohsu.edu" class="auth_mail" title="E-mail the corresponding author} ; Itai Chipinda^b ; Reuben H. Simoyi^a ; Paul D. Siegel^b

关键词：ACD ; Allergic contact dermatitis ; BQ ; p- benzoquinone ; BQD ; benzoquinone derivatives ; CBQ ; chlorobenzoquinone ; 2 ; 5-DCBQ ; 2 ; 5-dichlorobenzoquinone ; EDG ; electron donating groups ; EWG ; electron withdrawing groups ; ICD ; irritant contact dermatitis ; LLNA ; local lymph node assay ; EC3 ; estimated concentration that produces a 3 fold increase in lymph node cell proliferation over the vehicle control ; 2-MBQ ; 2 methyl- benzoquinone ; MA ; Michael addition ; NBT ; nitrobenzenethiol ; SI ; stimulation index ; 2-t

刊名：Toxicology

出版年：2016

9.Chemical applicability domain of the Local Lymph Node Assay (LLNA) for skin sensitization potency. Part 1. Underlying physical organic chemistry principles and the extent to which they are represented in the LLNA validation dataset

作者：D.W. Roberts^a ; ^{D.W.Roberts@ljmu.ac.uk" class="auth_mail" title="E-mail the corresponding author} ; A.M. Api^b ; G. Patlewicz^c ; ¹ ; T.W. Schultz^d

关键词：Skin sensitization ; Reactivity ; Electrophilicity ; Hydrophobicity ; Relative Alkylation Index (RAI) ; Skin penetration

刊名：Regulatory Toxicology and Pharmacology

出版年：2016

10.Chemical applicability domain of the Local Lymph Node Assay (LLNA) for skin sensitisation potency. Part 3. Apparent discrepancies between LLNA and GPMT sensitisation potential: False positives or differences in sensitivity?

作者：David W. Roberts^a ; ^{D.W.Roberts@ljmu.ac.uk" class="auth_mail" title="E-mail the corresponding author} ; Terry W. Schultz^b ; Anne Marie Api^c

关键词：Unsaturated fatty acids ; Surfactants ; Autoxidation

刊名：Regulatory Toxicology and Pharmacology

出版年：2016

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