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CNKI会议论文(1)
CNKI学位论文(163)
知网期刊论文(106)
在“
Elsevier电子期刊
”中,
命中:
72
条,耗时:0.0110017 秒
在所有数据库中总计命中:
270
条
1.
Inhibition of bile canalicular network formation in
rat
sandwich
cultured
hepatocytes
by drugs associated with risk of severe liver injury
作者:
Akinori Takemura
1
;
Aya Izaki
1
;
Shuichi Sekine
;
Kousei Ito
;
itokousei@chiba-u.jp" class="auth_mail" title="E-mail the corresponding author
关键词:
DILI
;
drug-induced liver injury
;
ALT
;
alanine aminotransferase
;
ALP
;
alkaline phosphatase
;
BBW
;
black box warning
;
WDN
;
withdrawn
;
BC
;
bile canalicular
;
BSEP
;
bile salt export pump
;
MRP2
;
multidrug resistance-associated protein 2
;
SCHs
;
sandwich
cultured
hepatocytes
;
WME
;
Williams' Medium E
;
DMEM
;
Dulbecco's Modified Eagle's Medium
;
TCA
;
taurocholic acid
;
LCA
;
lithocholic acid
;
LDH
;
lactate dehydrogenase
;
IC50
;
half maximal inhibitory concent
rat
ion
;
FDA
;
Food and Drug Administ
rat
ion
;
MDD
;
maximu
刊名:Toxicology in Vitro
出版年:2016
2.
Drug-induced cholestasis risk assessment in
sandwich
-
cultured
human
hepatocytes
作者:
Marlies Oorts
a
;
b
;
1
;
Marlies.Oorts@pharm.kuleuven.be" class="auth_mail" title="E-mail the corresponding author
;
Audrey Baze
b
;
1
;
a.baze@kaly-cell.com" class="auth_mail" title="E-mail the corresponding author
;
Philippe Bachellier
c
;
d
;
philippe.bachellier@chru-strasbourg.fr" class="auth_mail" title="E-mail the corresponding author
;
Bruno Heyd
c
;
e
;
bruno.heyd@univ-fcomte.fr" class="auth_mail" title="E-mail the corresponding author
;
Thomas Zacharias
f
;
zachariast@ch-mulhouse.fr" class="auth_mail" title="E-mail the corresponding author
;
Pieter Annaert
a
;
2
;
Pieter.Annaert@pharm.kuleuven.be" class="auth_mail" title="E-mail the corresponding author
;
Lysiane Richert
b
;
c
;
2
;
l.richert@kaly-cell.com" class="auth_mail" title="E-mail the corresponding author
关键词:
BAs
;
bile acids
;
Cmax
;
maximum plasma concent
rat
ion
;
CDF(DA)
;
5-(6)-carboxy-2&prime
;
7&prime
;
-dichlorofluorescein (diacetate)
;
DIC(I)
;
drug-induced cholestasis (index)
;
DILI
;
drug-induced liver injury
;
IMI
;
Innovative Medicine Initiative
;
MIP-DILI
;
Mechanism-Based Integ
rat
ed Systems for the Prediction of Drug-Induced Liver Injury
;
RMF
;
reactive metabolite formation
;
SC(H)H
;
sandwich
-
cultured
(human)
hepatocytes
;
SM
;
safety margin
;
TC
;
training compound
刊名:Toxicology in Vitro
出版年:2016
3.
Cytotoxicity evaluation using cryopreserved primary human
hepatocytes
in various culture formats
作者:
Lysiane Richert
a
;
h
;
l.richert@kaly-cell.com" class="auth_mail" title="E-mail the corresponding author
;
Audrey Baze
a
;
a.baze@kaly-cell.com" class="auth_mail" title="E-mail the corresponding author
;
Cé
;
line Parmentier
a
;
c.parmentier@kaly-cell.com" class="auth_mail" title="E-mail the corresponding author
;
Helga H.J. Gerets
b
;
helga.gerets@ucb.com" class="auth_mail" title="E-mail the corresponding author
;
Rowena Sison-Young
c
;
Rowena.Sison-Young@liverpool.ac.uk" class="auth_mail" title="E-mail the corresponding author
;
Martina Dorau
d
;
Martina.Dorau@sanofi.com" class="auth_mail" title="E-mail the corresponding author
;
Cerys Lovatt
e
;
cerys.a.lovatt@gsk.com" class="auth_mail" title="E-mail the corresponding author
;
Andreas Czich
d
;
Andreas.Czich@sanofi.com" class="auth_mail" title="E-mail the corresponding author
;
Christopher Goldring
c
;
C.E.P.Goldring@liverpool.ac.uk" class="auth_mail" title="E-mail the corresponding author
;
B. Kevin Park
c
;
B.K.Park@liv.ac.uk" class="auth_mail" title="E-mail the corresponding author
;
Satu Juhila
f
;
satu.juhila@orionpharma.com" class="auth_mail" title="E-mail the corresponding author
;
Alison J. Foster
g
;
Alison.Foster2@astrazeneca.com" class="auth_mail" title="E-mail the corresponding author
;
Dominic P. Williams
g
;
Dominic.P.Williams@astrazeneca.com" class="auth_mail" title="E-mail the corresponding author
关键词:
DILI
;
drug-induced liver injury
;
NPC
;
non-parenchymal cells
;
2D-sw
;
2D-
sandwich
;
SM
;
safety margin
;
MT
;
microtissue
;
TC
;
training compound
刊名:Toxicology Letters
出版年:2016
4.
Constrained spheroids for prolonged hepatocyte culture
作者:
Wen Hao Tong
a
;
b
;
c
;
Yu Fang
a
;
b
;
c
;
Jie Yan
a
;
c
;
g
;
Xin Hong
c
;
Nisha Hari Singh
a
;
Shu Rui Wang
d
;
Bramasta Nugraha
a
;
b
;
e
;
f
;
Lei Xia
c
;
Eliza Li Shan Fong
c
;
Ciprian Iliescu
a
;
ciliescu@ibn.a-star.edu.sg" class="auth_mail" title="E-mail the corresponding author
;
Hanry Yu
a
;
b
;
c
;
g
;
h
;
i
;
hanry_yu@nuhs.edu.sg" class="auth_mail" title="E-mail the corresponding author
关键词:
Hepatocytes
;
Spheroids
;
Liver
;
Perfusion
;
Drug testing
刊名:Biomaterials
出版年:2016
5.
Alpha-naphthylisothiocyanate modulates hepatobiliary transporters in
sandwich
-
cultured
rat
hepatocytes
作者:
Cen Guo
;
Lei He
;
Dan Yao
;
Jiye A
;
Bei Cao
;
Jin Ren
;
Guangji Wang
;
Guoyu Pan
关键词:
SCRH
;
sandwich
-
cultured
rat
hepatocytes
;
ANIT
;
alpha-naphthylisothiocyanate
;
Mrp
;
multidrug resistance-associated protein
;
Bsep
;
bile salt export pump
;
Ntcp
;
sodium/taurocholate cotransporting polypeptide
;
Oatp
;
organic anion transporting polypeptide
;
BEI
;
biliary excretion index
;
Clbiliary
;
biliary clearance
;
IPRLs
;
isolated perfused
rat
livers
;
BECs
;
biliary epithelial cells
;
Cyp7a1
;
cholesterol 7伪-hydroxylase
;
Cyp27a1
;
sterol 27-hydroxylase
;
Cyp8b1
;
sterol 12伪-hydroxylase
;
CDF
;
5 (and 6)-ca
刊名:Toxicology Letters
出版年:3 January, 2014
6.
Functional expression and regulation of drug transporters in monolayer- and
sandwich
-
cultured
mouse
hepatocytes
作者:
Gregory Noel
a
;
Marc Le Vee
a
;
Amé
;
lie Moreau
b
;
Bruno Stieger
c
;
Yannick Parmentier
b
;
Olivier Fardel
a
;
d
;
olivier.fardel@univ-rennes1.fr
关键词:
Drug transporters
;
Primary
hepatocytes
;
Mouse
;
Monolayer
;
Sandwich
;
Regulation
刊名:European Journal of Pharmaceutical Sciences
出版年:2013
7.
Toxicity and intracellular accumulation of bile acids in
sandwich
-
cultured
rat
hepatocytes
: Role of glycine conjugates
作者:
Sagnik Chatterjee
;
Ingrid T.G.W. Bijsmans
;
Saskia W.C. van Mil
;
Patrick Augustijns
;
Pieter Annaert
关键词:
BAs
;
bile acids
;
BAAT
;
bile acid CoA
;
amino acid N-acyltransferase
;
BEI
;
biliary excretion index
;
BSEP/Bsep
;
bile salt export pump (human/
rat
)
;
DMSO
;
dimethyl sulfoxide
;
CDCA
;
chenodeoxycholic acid
;
CA
;
cholic acid
;
FBS
;
Fetal Bovine Serum GCDCA
;
glycochenodeoxycholic acid
;
GDCA
;
glycodeoxycholic acid
;
HBSS
;
Hanks&rsquo
;
Balanced Salt Solution
;
HEPES
;
4-(2-hydroxyethyl)-1-piperazine ethanesulfonic acid
;
NOAEL
;
no observed adverse effect level
;
NTCP/Ntcp
;
sodium taurocholate cotransporting polype
刊名:Toxicology in Vitro
出版年:March, 2014
8.
Opposite regulation of hepatic breast cancer resistance protein in type 1 and 2 diabetes mellitus
作者:
Lei He
;
Yuan Yang
;
Cen Guo
;
Dan Yao
;
Hui-hui Liu
;
Jing-jing Sheng
;
Wei-ping Zhou
;
Jin Ren
;
Xiao-dong Liu
;
Guo-yu Pan
关键词:
Diabetes
;
Sandwich
cultured
rat
hepatocytes
;
Breast cancer resistant protein
刊名:European Journal of Pharmacology
出版年:5 February, 2014
9.
A rapid and sensitive assay to quantify valproyl 1-O-acyl glucuronide in supernatants of
sandwich
-
cultured
rat
hepatocytes
using ultra-high performance liquid chromatography-tandem mass spectrometry
作者:
Jayakumar Surendradoss
;
Andr¨¢s Szeitz
;
Xiao Wei Teng
;
Thomas K.H. Chang
;
Frank S. Abbott
关键词:
VPA-G
;
valproyl 1-O-acyl glucuronide
;
VPA
;
valproic acid
;
UHPLC&ndash
;
MS/MS
;
ultra-high performance liquid chromatography&ndash
;
tandem mass spectrometry
;
IS
;
internal standard
;
MRM
;
multiple reaction monitoring
;
SIM
;
selected ion monitoring
;
TIC
;
total io
刊名:Journal of Chromatography B, Analytical Technologies in the Biomedical and Life Sciences
出版年:2013
10.
Biopharmaceutical profiling of a pyrido[4,3-d] pyrimidine compound library
作者:
Benjamin Wuyts
;
Janneke Keemink
;
Steven De Jonghe
;
Pieter Annaert
;
Patrick Augustijns
关键词:
Pyrido[4
;
3-d]pyrimidines
;
Biopharmaceutical profiling
;
Caco-2
;
Suspended
rat
hepatocytes
;
Sandwich
cultured
rat
hepatocytes
;
Clearance prediction
刊名:International Journal of Pharmaceutics
出版年:2013
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