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在“Elsevier电子期刊”中，命中：209条，耗时：0.0180204 秒

在所有数据库中总计命中：1,977条

1.The efficacy of tyrosine kinase inhibitor dasatinib on colonic mucosal damage in murine model of colitis

关键词：Ab ; Abelson ; CD ; Crohn's disease ; CML ; Chronic myeloid leukemia ; DAI ; Disease activity index ; DC ; Dentritic cell ; IBD ; Inflammatory bowel disease ; IL ; Interleukin ; LGL ; Large granular lymphocytosis ; MDA ; Malondialdehyde ; MPO ; Myeloperoxidase ; NFкβ ; Nuclear factor kappa beta ; PDGFR ; Platelet derived growth factor receptor ; SFK ; Src family kinases ; SOD ; Superoxide dismutase ; Syk ; Spleen tyrosine kinase ; TNFα ; Tumor necrosis factor-alpha ; TK ; Tyrosine kinase ; UC ; Ulcerative colitis

刊名：Clinics and Research in Hepatology and Gastroenterology

出版年：2016

2.Inhibition of spleen tyrosine kinase (syk) suppresses renal fibrosis through anti-inflammatory effects and down regulation of the MAPK-p38 pathway

作者：Kuan-Hsing Chen ; Hsiang-Hao Hsu ; Huang-Yu Yang ; Ya-Chung Tian ; Yi-Ching Ko ; Chih-Wei Yang ; Cheng-Chieh Hung ; ^{cchung9651@yahoo.com" class="auth_mail" title="E-mail the corresponding author}

关键词：Renal fibrosis ; Spleen tyrosine kinase (Syk) ; Transforming growth factor-β1 ; MAPK ; Unilateral ureteral obstruction

刊名：International Journal of Biochemistry and Cell Biology

出版年：2016

3.Discovery of TAK-659 an orally available investigational inhibitor of Spleen Tyrosine Kinase (SYK)

作者：Betty Lam^a ; ^{betty.lam@takeda.com} ; Yasuyoshi Arikawa^b ; Joshua Cramlett^c ; Qing Dong^d ; Ron de Jong^a ; Victoria Feher^e ; Charles E. Grimshaw^a ; Pamela J. Farrell^a ; Isaac D. Hoffman^a ; Andy Jennings^a ; Benjamin Jones^a ; Jennifer Matuszkiewicz^f ; Joanne Miura^a ; Hiroshi Miyake^b ; Srinivasa Reddy Natala^g ; Lihong Shi^f ; Masashi Takahashi^b ; Ewan Taylor^a ; Corey Wyrick^a ; Jason Yano^h ; Jonathan Zalevskyⁱ ; Zhe Nie^f

关键词：SYK ; Kinase inhibitor ; Kinase selectivity ; Structure-based drug discovery ; Leukemia ; Lymphoma

刊名：Bioorganic & Medicinal Chemistry Letters

出版年：2016

4.Synthesis and optimization of furano[3,2-d]pyrimidines as selective spleen tyrosine kinase (Syk) inhibitors

作者：Michael Hoemann^a ; ; Noel Wilson^b ; ; Maria Argiriadi^a ; David Banach^a ; Andrew Burchat^a ; David Calderwood^a ; Bruce Clapham^c ; Phil Cox^b ; David B. Duignan^a ; Don Konopacki^a ; Gagandeep Somal^a ; Anil Vasudevan^b

关键词：Spleen tyrosine kinase ; Furano[3 ; 2-d]pyrimidine ; Syk ; Rheumatoid arthritis ; Kinase inhibitor

刊名：Bioorganic & Medicinal Chemistry Letters

出版年：2016

5.C-Type Lectin-Like Receptor 2 Suppresses AKT Signaling and Invasive Activities of Gastric Cancer Cells by Blocking Expression of Phosphoinositide 3-Kinase Subunits

作者：Lan Wang¹ ; ² ; ³ ; ^&lowast ; ; Jie Yin⁴ ; ^&lowast ; ; Xuefei Wang⁵ ; ^&lowast ; ; Miaomiao Shao¹ ; ² ; Fangfang Duan¹ ; ³ ; Weicheng Wu¹ ; ² ; Peike Peng¹ ; ² ; Jing Jin⁶ ; Yue Tang¹ ; ² ; Yuanyuan Ruan¹ ; ² ; ^{yuanyuanruan@fudan.edu.cn" class="auth_mail" title="E-mail the corresponding author} ; Yihong Sun⁵ ; ^{sun.yihong@zs-hospital.sh.cn" class="auth_mail" title="E-mail the corresponding author} ; Jianxin Gu¹ ; ² ; ³ ; ^{jxgu@shmu.edu.cn" class="auth_mail" title="E-mail the corresponding author}

关键词：Spleen Tyrosine Kinase ; DNA Methylation ; Tumor Suppressor ; Inflammatory Homeostasis

刊名：Gastroenterology

出版年：2016

6.A role for spleen tyrosine kinase in renal fibrosis in the mouse obstructed kidney

作者：Frank Y. Ma^a ; ^b ; Kate Blease^c ; David J. Nikolic-Paterson^a ; ^b ; ^{david.nikolic-paterson@monash.edu" class="auth_mail" title="E-mail the corresponding author}

关键词：Syk ; Renal fibrosis ; Fibroblast ; Macrophage ; Immunohistochemistry ; UUO

刊名：Life Sciences

出版年：2016

7.Interfering with baffled B cells at the lupus tollway: Promises, successes, and failed expectations

作者：Namrata Singh ; MD ; Bharat Kumar ; MD ; Vijay Aluri ; MD ; Petar Lenert ; MD ; PhD ; ^{petar-lenert@uiowa.edu" class="auth_mail" title="E-mail the corresponding author}

关键词：B cells ; systemic lupus erythematosus ; Toll-like receptors ; B-cell receptor for antigen ; type I interferon ; B cell activating factor ; Bruton tyrosine kinase ; spleen tyrosine kinase ; Lyn

刊名：Journal of Allergy and Clinical Immunology

出版年：2016

8.Optimisation of a novel series of potent and orally bioavailable azanaphthyridine SYK inhibitors

作者：Neil S. Garton^a ; ^{Neil.S.Garton@gsk.com" class="auth_mail" title="E-mail the corresponding author} ; Michael D. Barker^a ; Rob P. Davis^a ; Clement Douault^a ; Edward Hooper-Greenhill^a ; Emma Jones^a ; Huw D. Lewis^a ; John Liddle^a ; Dave Lugo^a ; Scott McCleary^a ; Alex G.S. Preston^a ; Cesar Ramirez-Molina^a ; Margarete Neu^a ; Tracy J. Shipley^a ; Don O. Somers^a ; Robert J. Watson^a ; David M. Wilson^b

关键词：SYK ; Spleen Tyrosine Kinase ; Selective ; Potent ; Orally bioavailable ; Azanaphthyridine ; Lead optimisation ; Medicinal chemistry

刊名：Bioorganic & Medicinal Chemistry Letters

出版年：2016

9.Resveratrol preferentially inhibits IgE-dependent PGD₂ biosynthesis but enhances TNF production from human skin mast cells

作者：Devon Shirley ^{devon.shirley@uscmed.sc.edu" class="auth_mail" title="E-mail the corresponding author} ; Cody McHale ^{mchalecc@email.sc.edu" class="auth_mail" title="E-mail the corresponding author} ; Gregorio Gomez ; ^{gregorio.gomez@uscmed.sc.edu" class="auth_mail" title="E-mail the corresponding author}

关键词：IgE ; immunoglobulin E ; PGD2 ; prostaglandin D2 ; COX-1 ; cyclooxygenase-1 ; COX-2 ; cyclooxygenase-2 ; Syk ; spleen tyrosine kinase ; TNF ; tumor necrosis factor ; IL-6 ; interleukin-6

刊名：Biochimica et Biophysica Acta (BBA) - General Subjects

出版年：2016

10.Screening and functional analysis of differentially expressed genes in chronic glomerulonephritis by whole genome microarray

作者：Jia-rong Gao^a ; ^{zyfygjr2006@163.com" class="auth_mail" title="E-mail the corresponding author} ; Xiu-juan Qin^b ; ^{1036951872@qq.com" class="auth_mail" title="E-mail the corresponding author} ; Hui Jiang^a ; ^{657861261@qq.com" class="auth_mail" title="E-mail the corresponding author} ; Ting Wang^b ; ^{136931653@qq.com" class="auth_mail" title="E-mail the corresponding author} ; Jun-mei Song^b ; ^{1548009478@qq.com" class="auth_mail" title="E-mail the corresponding author} ; Shuang-zhi Xu^b ; ^{1521316853@qq.com" class="auth_mail" title="E-mail the corresponding author}

关键词：CGN ; chronic glomerulonephritis ; GO ; gene ontology ; RT-PCR ; real-time polymerase chain reaction ; IP ; intraperitoneal injection ; H&E ; hematoxylin and eosin ; SPSS ; Statistic Package for Social Science ; GBMT ; glomerular basement membrane thickness ; ICAM-1 ; intercellular adhesion molecule-1 ; Anxa1 ; annexin a1 ; CRD ; carbohydrate-recognition-binding domain ; Kng ; kininogen ; BCR ; B-cell antigen receptor ; Syk ; spleen tyrosine kinase ; HSPG ; heparan sulfate proteoglycan ; Runt-Related Transcription Factor 1

刊名：Gene

出版年：2016

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