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在“Elsevier电子期刊”中，命中：5,859条，耗时：0.1819055 秒

在所有数据库中总计命中：37,567条

1.Structure-activity relationships of diverse xanthones against multidrug resistant human tumor cells

作者：Qiwen Wang^a ; Chenyao Ma^a ; Yun Ma^a ; Xiang Li^a ; ^c ; ^{lixiang_8182@163.com} ; Yong Chen^a ; ^{achenyongmail@163.com} ; Jianwei Chen^a ; ^b

关键词：Xanthone ; Cytotoxic activity ; Multidrug resistant ; Structure-activity relationships

刊名：Bioorganic & Medicinal Chemistry Letters

出版年：2017

2.Diversity selection, screening and quantitative structure-activity relationships of osmolyte-like additive effects on the thermal stability of a monoclonal antibody

作者：Olubukayo-Opeyemi Oyetayo^a ; ^{oyetayophdhbc@gmail.com} ; Oscar Mé ; ndez-Lucio^b ; Andreas Bender^b ; Hans Kiefer^a

关键词：mAb ; Monoclonal antibody ; MOE ; Molecular Operating Environment ; MDS ; Multi-dimensional scaling ; QSAR ; Quantitative structure&ndash ; activity relationship ; DSC ; Differential scanning calorimetry ; DSF ; Differential scanning fluorimetry ; DMSO ; Dimethyl sulfoxide ; NaOH ; Sodium hydroxide ; HCl ; Hydrochloric acid ; LOO-CV ; Leave-one-out cross-validation ; PCA ; Principal components analysis ; PLS ; Partial least squares ; TMAO ; Trimethylamine N-oxide ; Tm ; Melting temperature ; TS potency ; Thermal stabilization

刊名：European Journal of Pharmaceutical Sciences

出版年：2017

3.Structure-activity relationships and optimization of acyclic acylphloroglucinol analogues as novel antimicrobial agents

作者：Haibo Tan^a ; ¹ ; Hongxin Liu^a ; ^b ; ¹ ; Liyun Zhao^a ; ^c ; Yao Yuan^a ; ^c ; Bailin Li^a ; ^c ; Yueming Jiang^a ; Liang Gong^a ; ^{lianggong@scbg.ac.cn} ; Shengxiang Qiu^a ; ^{sxqiu@scbg.ac.cn}

关键词：Anti-MRSA ; Acylphloroglucinol ; Mechanism ; Structure-activity relationship

刊名：European Journal of Medicinal Chemistry

出版年：2017

4.Discovery of biphenyl imidazole derivatives as potent antifungal agents: Design, synthesis, and structure-activity relationship studies

作者：Dongmei Zhao^a ; ^{medchemzhao@163.com} ; Shizhen Zhao^a ; Liyu Zhao^a ; Xiangqian Zhang^a ; Peng Wei^a ; Chunchi Liu^a ; Chenzhou Hao^a ; Bin Sun^c ; Xin Su^b ; ^{suxin1966@163.com} ; Maosheng Cheng^a

关键词：Antifungal activity ; CYP51 ; Structure-activity relationship ; Azole antifungals

刊名：Bioorganic & Medicinal Chemistry

出版年：2017

5.Design, synthesis and structure-activity relationship of 4,5-dihydropyrrolo[3,4-c]pyrazol-6(1H)-ones as potent p53-MDM2 inhibitors

作者：Wei-Huang Zhou^a ; ^b ; Xi-Guo Xu^a ; ^b ; Jin Li^b ; Xiao Min^b ; Jian-Zhong Yao^b ; Guo-Qiang Dong^b ; Chun-Lin Zhuang^b ; ^{zclnathan@163.com} ; Zhen-Yuan Miao^b ; ^{miaozhenyuan@hotmail.com} ; Wan-Nian Zhang^a ; ^b ; ^{zhangwnk@hotmail.com}

关键词：p53-MDM2 ; Protein&ndash ; protein interaction ; Inhibitors ; Drug design ; Structure&ndash ; activity relationships ; Antiproliferative

刊名：Chinese Chemical Letters

出版年：2017

6.Synthesis, structure-activity relationships and biological evaluation of 7-phenyl-pyrroloquinolinone 3-amide derivatives as potent antimitotic agents

作者：Davide Carta^a ; Roberta Bortolozzi^b ; Mattia Sturlese^a ; Veronica Salmaso^a ; Ernest Hamel^c ; Giuseppe Basso^b ; Laura Calderan^a ; Luigi Quintieri^a ; Stefano Moro^a ; Giampietro Viola^b ; Maria Grazia Ferlin^a ; ^{mariagrazia.ferlin@unipd.it}

关键词：Microtubules ; Phenylpyrroloquinolinone ; Tubulin ; Apoptosis ; Molecular docking ; Structure-activity relationships

刊名：European Journal of Medicinal Chemistry

出版年：2017

7.A matrix-focused structure-activity and binding site flexibility study of quinolinol inhibitors of botulinum neurotoxin serotype A

作者：William A. Harrell Jr.^a ; ^d ; Rebecca C. Vieira^a ; ^e ; Susan M. Ensel^b ; Vicki Montgomery^a ; Rebecca Guernieri^a ; Vanessa S. Eccard^a ; ^f ; Yvette Campbell^a ; Virginia Roxas-Duncan^a ; ^g ; John H. Cardellina II^a ; ^h ; Robert P. Webb^a ; ^{robert.p.webb6.civ@mail.mil} ; Leonard A. Smith^c

关键词：BoNTs ; botulinum neurotoxins ; BoNT/A ; botulinum neurotoxin serotype A ; HC ; heavy chain ; LC ; light chain ; SNARE ; soluble N-ethylmaleimide-sensitive factor attachment protein receptor ; SNAP-25 ; 25 ; kDa synaptosomal-associated protein ; BIG-IV ; Botulism Immune Globulin Intravenous (Human) ; SAR ; structure-activity relationship ; IC50 ; 50% inhibitory concentration ; MPNHDA ; mouse phrenic nerve hemidiaphragm assay

刊名：Bioorganic & Medicinal Chemistry Letters

出版年：2017

8.Structure-activity relationships of cinnamaldehyde and eugenol derivatives against plant pathogenic fungi

作者：Yongjian Xie^a ; Qianqian Huang^a ; Zhunjing Wang^a ; Haiyan Cao^b ; Dayu Zhang^a ; ^{zhangdayu@zafu.edu.cn}

关键词：Antifungal activity ; Cinnamaldehyde derivatives ; Eugenol derivatives ; Rhizoctonia solani ; Fusarium oxysporum

刊名：Industrial Crops and Products

出版年：2017

9.Novel anti-tumour barringenol-like triterpenoids from the husks of Xanthoceras sorbifolia Bunge and their three dimensional quantitative structure activity relationships analysis

作者：Da Wang^a ; Dan Su^a ; Bin Yu^a ; Chuming Chen^b ; Li Cheng^a ; Xianzhe Li^a ; Ronggang Xi^c ; Huiyuan Gao^a ; ¹ ; ^{sypugaohy@163.com} ; Xiaobo Wang^c ; ^{wxbbenson0653@163.com}

关键词：Xanthoceras sorbifolia Bunge ; Barrigenol-type triterpenoid ; Antitumor activities ; CoMFA ; CoMSIA ; Health benefits

刊名：Fitoterapia

出版年：2017

10.The anti-proliferative activity of novel 4H-benzo[h]chromenes, 7H-benzo[h]-chromeno[2,3-d]pyrimidines and the structure-activity relationships of the 2-, 3-positions and fused rings at the 2, 3-positions

作者：Ahmed M. El-Agrody^a ; ^b ; ^{elagrody_am@yahoo.com} ; Ahmed H. Halawa^a ; Ahmed M. Fouda^b ; Al-Anood M. Al-Dies^b

关键词：4H-Benzo[h]chromenes ; 7H-Benzo[h]chromeno[2 ; 3-d]pyrimidines ; Antitumor ; SAR

刊名：Journal of Saudi Chemical Society

出版年：2017

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