设为首页
收藏本站
网站地图
|
English
|
公务邮箱
About the library
Background
History
Leadership
Organization
Readers' Guide
Opening Hours
Collections
Help Via Email
Publications
Electronic Information Resources
常用资源
电子图书
期刊论文
学位会议
外文资源
特色专题
内部出版物
在“
Elsevier电子期刊
”中,
命中:
1,957
条,耗时:0.034983 秒
1.
Gamma
secretase
inhibitor impairs epithelial-to-mesenchymal transition induced by TGF-β in ovarian tumor cell lines
作者:
M.C. Pazos
mariacamilapazos@gmail.com
;
D. Abramovich
dnabramovich@gmail.com
;
A. Bechis
andy_bechis@hotmail.com
;
P. Accialini
paccialini@gmail.com
;
F. Parborell
fparborell@gmail.com
;
M. Tesone
martatesone.uba@gmail.com
;
G. Irusta
;
irustag@gmail.com
关键词:
Gamma
secretase
inhibitor
;
Epithelial-to-mesenchymal transition
;
TGF-β
;
Cadherin switch
;
Metastasis
;
Ovarian cancer
刊名:Molecular and Cellular Endocrinology
出版年:2017
2.
Mapping the Binding Site of BMS-708163 on γ-
Secretase
with Cleavable Photoprobes
作者:
Natalya Gertsik
1
;
2
;
Christopher W. am Ende
3
;
Kieran F. Geoghegan
4
;
Chuong Nguyen
4
;
Paramita Mukherjee
3
;
Scot Mente
5
;
Uthpala Seneviratne
5
;
Douglas S. Johnson
5
;
doug.johnson@pfizer.com
;
Yue-Ming Li
1
;
6
;
7
;
liy2@mskcc.org
关键词:
Alzheimer's disease
;
cleavable linkers
;
photoaffinity labeling
;
peptide mapping
;
molecular dynamics simulations
刊名:Cell Chemical Biology
出版年:2017
3.
Presenilin 1 mutations influence processing and trafficking of the ApoE receptor apoER2
作者:
Wei Wang
a
;
1
;
Andrea M. Moerman-Herzog
a
;
2
;
Arthur Slaton
a
;
Steven W. Barger
a
;
b
;
c
;
bargerstevenw@uams.edu
关键词:
Alzheimer's disease
;
ApoER2
;
γ-
Secretase
;
Lipoprotein receptor
;
Presenilin
;
Protein processing
;
Protein trafficking
刊名:Neurobiology of Aging
出版年:2017
4.
Aging process alters hippocampal and cortical
secretase
activities of Wistar rats
作者:
Karine Bertoldi
a
;
Laura Reck Cechinel
a
;
Bruna Schallenberger
d
;
Louisiana Meireles
a
;
Carla Basso
a
;
Gisele Agustini Lovatel
b
;
Lisiane Bernardi
c
;
Marcelo Lazzaron Lamers
c
;
Ionara Rodrigues Siqueira
a
;
d
;
ionara@ufrgs.br" class="auth_mail" title="E-mail the corresponding author
关键词:
Hippocampus
;
Prefrontal cortex
;
Amyloid precursor protein
;
BACE
;
TACE
;
Aging
刊名:Behavioural Brain Research
出版年:2017
5.
Anomalies occurring in lipid profiles and protein distribution in frontal cortex lipid rafts in dementia with Lewy bodies disclose neurochemical traits partially shared by Alzheimer's and Parkinson's diseases
作者:
Raquel Marin
a
;
Noemí
;
Fabelo
b
;
Virginia Martí
;
n
c
;
Paula Garcia-Esparcia
d
;
Isidre Ferrer
d
;
David Quinto-Alemany
b
;
Mario Dí
;
az
b
;
madiaz@ull.es
关键词:
Lipid rafts
;
Docosahexaenoic acid
;
Cholesterol
;
Plasmalogens
;
β-
secretase
;
Amyloid precursor protein
;
Amyloidogenic processing
;
Human brain cortex
;
Lewy body diseases
;
Alzheimer's disease
;
Parkinson's disease
刊名:Neurobiology of Aging
出版年:2017
6.
Neuritogenic activity of bi-functional bis-tryptoline triazole
作者:
Jutamas Jiaranaikulwanitch
a
;
b
;
jutamas.jia@cmu.ac.th
;
Sarin Tadtong
c
;
Piyarat Govitrapong
d
;
Valery V. Fokin
e
;
Opa Vajragupta
b
关键词:
Bis-tryptoline triazole
;
Multifunctional activity
;
Neuritogenic activity
;
β-
secretase
inhibitor
;
β-amyloid aggregation
刊名:Bioorganic & Medicinal Chemistry
出版年:2017
7.
Multi-target-directed therapeutic potential of 7-methoxytacrine-adamantylamine heterodimers in the Alzheimer's disease treatment
作者:
Zuzana Gazova
a
;
gazova@saske.sk
;
Ondrej Soukup
b
;
c
;
d
;
Vendula Sepsova
b
;
c
;
Katarina Siposova
a
;
Lucie Drtinova
c
;
Petr Jost
b
;
c
;
Katarina Spilovska
b
;
c
;
d
;
Jan Korabecny
b
;
c
;
d
;
Eugenie Nepovimova
b
;
c
;
Diana Fedunova
a
;
Martin Horak
e
;
Martina Kaniakova
e
;
Ze-Jun Wang
f
;
Ayman K. Hamouda
f
;
Kamil Kuca
b
;
c
;
d
关键词:
Amyloid
;
Aggregation
;
Aβ peptide
;
Muscarinic/nicotinic acetylcholine receptor antagonist
;
N-Methyl-d-aspartate receptor antagonist
;
β-
Secretase
inhibitor
;
Alzheimer's disease
刊名:Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease
出版年:2017
8.
Design, synthesis and biological evaluation of new phthalimide and saccharin derivatives with alicyclic amines targeting cholinesterases, beta-
secretase
and amyloid beta aggregation
作者:
Dawid Panek
a
;
1
;
Anna Więckowska
a
;
1
;
Tomasz Wichur
a
;
Marek Bajda
a
;
Justyna Godyń
a
;
Jakub Jończyk
a
;
Kamil Mika
a
;
Jana Janockova
b
;
Ondrej Soukup
b
;
Damijan Knez
c
;
Jan Korabecny
b
;
Stanislav Gobec
c
;
Barbara Malawska
a
;
mfmalaws@cyf-kr.edu.pl
关键词:
Alzheimer's disease
;
Multifunctional agents
;
Acetylcholinesterase inhibitors
;
BACE1 inhibitors
;
Aβ aggregation
;
Molecular docking
刊名:European Journal of Medicinal Chemistry
出版年:2017
9.
Design, synthesis and SAR analysis of potent BACE1 inhibitors: Possible lead drug candidates for Alzheimer's disease
作者:
Hamadeh Tarazi
a
;
b
;
Raed Abu Odeh
b
;
c
;
Raed Al-Qawasmeh
d
;
Imad Abu Yousef
e
;
Wolfgang Voelter
f
;
Taleb H. Al-Tel
a
;
b
;
taltal@sharjah.ac.ae
关键词:
β-
secretase
inhibitors
;
Alzheimer's disease
;
Transition state mimics
;
Structure-based drug design
;
Structure activity relationship
;
Isophthalic acid derivatives
;
Molecular modeling
刊名:European Journal of Medicinal Chemistry
出版年:2017
10.
BIIB042, a novel γ-
secretase
modulator, reduces amyloidogenic Aβ isoforms in primates and rodents and plaque pathology in a mouse model of Alzheimer's disease
作者:
Robert H. Scannevin
a
;
robert.scannevin@biogen.com" class="auth_mail" title="E-mail the corresponding author
;
Sowmya Chollate
a
;
1
;
Melanie S. Brennan
a
;
Pamela A. Snodgrass-Belt
a
;
2
;
Hairuo Peng
b
;
Lin Xu
c
;
Mi-young Jung
a
;
Thierry Bussiere
a
;
Mahin F. Arastu
a
;
3
;
Tina Talreja
b
;
4
;
Zhili Xin
b
;
Robert W. Dunstan
d
;
Diana Fahrer
d
;
Ellen Rohde
c
;
5
;
Anthone W. Dunah
a
;
Joy Wang
a
;
6
;
Gnanasambandam Kumaravel
b
;
Arthur G. Taveras
b
;
7
;
H. Moore Arnold
a
;
Kenneth J. Rhodes
a
;
8
关键词:
Amyloid β
;
γ-
Secretase
;
γ-
Secretase
modulator
;
Alzheimer's disease
;
Amyloid precursor protein
刊名:Neuropharmacology
出版年:2016
1
2
3
4
5
6
7
8
9
按检索点细分(1957)
题名(1034)
关键词(636)
文摘(1216)
按出版年细分(1957)
2027年及以后(63)
2017年(15)
2016年(91)
2015年(29)
2014年(1)
2013年(96)
2012年(152)
2011年(191)
2010年(178)
2009年(145)
2008年(182)
2007年(114)
2006年(155)
2005年(68)
2004年(136)
2003年(52)
2002年(62)
2001年(29)
2000年(59)
2000年及以前(139)
NGLC 2004-2010.National Geological Library of China All Rights Reserved.
Add:29 Xueyuan Rd,Haidian District,Beijing,PRC. Mail Add: 8324 mailbox 100083
For exchange or info please contact us via
email
.