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在“Elsevier电子期刊”中，命中：103条，耗时：0.0129899 秒

在所有数据库中总计命中：257条

1.Intracellular signaling modifications involved in the anti-inflammatory effect of 4-alkoxy-6,9-dichloro[1,2,4]triazolo[4,3-a]quinoxalines on macrophages

作者：Antonio J. Ruiz-Alcaraz^a ; ^ajruiz@um.es ; Marí ; a Tristá ; n-Manzano^a ; Antonio Guirado^b ; Jesú ; s Gá ; lvez^c ; Marí ; a Martí ; nez-Esparza^a ; Pilar Garcí ; a-Peñ ; arrubia^a ; ^{pigarcia@um.es}

关键词：ATF ; activating transcription factor ; CCM ; complete culture medium ; ERK ; extracellular signal-regulated kinase ; IKK ; IκB kinase ; IL-6 ; interleukin 6 ; JNK ; c-Jun N-terminal kinase ; LPS ; lipopolysaccharide ; MAPK ; mitogen-activated protein kinase ; NSAIDs ; non-steroidal anti-inflammatory drugs ; NFκB ; nuclear factor kappa-light-chain-enhancer of activated B cells ; PAMP ; pathogen-associated molecular patterns ; PI3K ; phosphatidylinositol 3-kinase ; PKB ; protein kinase B ; PRRs ; PAMP recognition receptors

刊名：European Journal of Pharmaceutical Sciences

出版年：2017

2.Preclinical characterization of substituted 6,7-dihydro-[1,2,4]triazolo[4,3-a]pyrazin-8(5H)-one P2X7 receptor antagonists

作者：Michael K. Ameriks ; Hong Ao ; Nicholas I. Carruthers ; Brian Lord ; Suchitra Ravula ; Jason C. Rech ; Brad M. Savall ; Jessica L. Wall ; Qi Wang ; Anindya Bhattacharya ; Michael A. Letavic

关键词：P2X7 ; 6 ; 7-Dihydro-[12 ; 4]triazolo[4 ; 3-a]pyrazin-8(5H)-one ; Autoradiography ; Depression ; CNS

刊名：Bioorganic & Medicinal Chemistry Letters

出版年：2016

3.Keeping it small, polar, and non-flat: diversely functionalized building blocks containing the privileged 5,6,7,8-tetrahydro[1,2,4]triazolo[4,3-a]- and [1,5-a]pyridine cores

作者：Alexander Mishchuk^a ; Natalia Shtil^b ; Mykola Poberezhnyk^c ; Konstiantyn Nazarenko^a ; ^b ; Timur Savchenko^a ; Andrey Tolmachev^a ; Mikhail Krasavin^d ; ^{m.krasavin@spbu.ru" class="auth_mail" title="E-mail the corresponding author}

关键词：Lead-oriented synthesis ; Non-flat heterocycles ; Hydrogenation ; Dimroth rearrangement ; Anti-diabetes drugs

刊名：Tetrahedron Letters

出版年：2016

4.Synthesis, antitumor evaluation and 3D-QSAR studies of [1,2,4]triazolo[4,3-b][1,2,4,5]tetrazine derivatives

作者：Feng Xu^a ; ^{xufeng901@126.com" class="auth_mail" title="E-mail the corresponding author} ; Zhen-zhen Yang^a ; Zhong-lu Ke^a ; Li-min Xi^a ; Qi-dong Yan^a ; Wei-qiang Yang^b ; Li-qing Zhu^a ; Fei-lei Lin^a ; Wei-ke Lv^a ; Han-gui Wu^a ; John Wang^c ; Hai-bo Li^d

关键词：SSHHAQKQMJBRPW-UHFFFAOYSA-N

刊名：Bioorganic & Medicinal Chemistry Letters

出版年：2016

5.New 2H-[1,2,3]triazolo[4,5-e][1,2,4]triazolo[1,5-a]pyrimidine derivatives as luminescent fluorophores for detection of nitroaromatic explosives

作者：Egor V. Verbitskiy^a ; ^b ; ^{Verbitsky@ios.uran.ru" class="auth_mail" title="E-mail the corresponding author} ; Evgeny B. Gorbunov^a ; ^b ; Anna A. Baranova^b ; Kseniya I. Lugovik^b ; Konstantin O. Khokhlov^b ; Ekaterina M. Cheprakova^a ; Grigory A. Kim^a ; Gennady L. Rusinov^a ; ^b ; Oleg N. Chupakhin^a ; ^b ; Valery N. Charushin^a ; ^b

关键词：Pyrimidine ; Carbazole ; Triphenylamine ; Nitroaromatic explosives ; Fluorescence quenching

刊名：Tetrahedron

出版年：2016

6.Spectroscopic investigation, molecular interactions and molecular docking studies on 8-chloro-1-methyl-6-phenyl-4H-[1,2,4]triazolo[4,3-a][1,4]benzodiazepine

作者：B. Sylaja^a ; ^c ; ^{shylaja_b@ymail.com" class="auth_mail" title="E-mail the corresponding author} ; S. Gunasekaran^b ; S. Srinivasan^c

关键词：FTIR ; Alprazolam ; Vibrational analysis ; 13C and 1H NMR chemical shift

刊名：Optik - International Journal for Light and Electron Optics

出版年：2016

7.Synthesis, antitumor evaluation and molecular docking studies of [1,2,4]triazolo[4,3-b][1,2,4,5]tetrazine derivatives

作者：Feng Xu^a ; ^{xufeng901@126.com" class="auth_mail" title="E-mail the corresponding author} ; Zhen-zhen Yang^a ; Jun-rong Jiang^a ; Wan-gui Pan^a ; Xiao-le Yang^a ; Jian-yong Wu^a ; Yan Zhu^a ; John Wang^b ; Qi-Yang Shou^c ; Han-gui Wu^a

关键词：VQMBYCGKKNTCPS-UHFFFAOYSA-N

刊名：Bioorganic & Medicinal Chemistry Letters

出版年：2016

8.Discovery of novel 5,6,7,8-tetrahydro[1,2,4]triazolo[4,3-a]pyridine derivatives as γ-secretase modulators (Part 2)

作者：Takafumi Takai ; ^{takafumi.takai@takeda.com" class="auth_mail" title="E-mail the corresponding author} ; Tatsuki Koike ; Minoru Nakamura ; Yuichi Kajita ; Toshiro Yamashita ; Naohiro Taya ; Tetsuya Tsukamoto ; Tomomichi Watanabe ; Koji Murakami ; Tomoko Igari ; Makoto Kamata

关键词：GSM ; γ-secretase modulator ; Aβ ; amyloid beta ; AD ; Alzheimer&rsquo ; s disease ; LLE ; ligand-lipophilicity efficiency ; NORT ; novel object recognition test ; APP ; amyloid precursor protein ; MLM ; mice liver microsomes ; CNS ; central nervous system ; WT ; wild type

刊名：Bioorganic & Medicinal Chemistry

出版年：2016

9.Synthesis and biological evaluation of new [1,2,4]triazolo[4,3-a]pyridine derivatives as potential c-Met inhibitors

作者：Junjun Zhao^a ; ^b ; ^&dagger ; ; Lei Fang^a ; ^&dagger ; ; Xiaobing Zhang^b ; Yan Liang^b ; Shaohua Gou^a ; ^{sgou@seu.edu.cn" class="auth_mail" title="E-mail the corresponding author}

关键词：Antitumor ; c-Met inhibitors ; Selectivity ; Pharmacokinetic profile

刊名：Bioorganic & Medicinal Chemistry

出版年：2016

10.Discovery of 6-(difluoro(6-(4-fluorophenyl)-[1,2,4]triazolo[4,3-b][1,2,4]triazin-3-yl)methyl)quinoline as a highly potent and selective c-Met inhibitor

作者：Zhengsheng Zhan^a ; ¹ ; Xia Peng^b ; ¹ ; Qiufeng Liu^c ; ¹ ; Fang Chen^a ; ¹ ; Yinchun Ji^b ; Shanyan Yao^a ; Yong Xi^b ; Yipeng Lin^a ; Tiantian Chen^c ; Yechun Xu^c ; ^{ycxu@simm.ac.cn" class="auth_mail" title="E-mail the corresponding author} ; Jing Ai^b ; ^{jai@simm.ac.cn" class="auth_mail" title="E-mail the corresponding author} ; Meiyu Geng^b ; ^{mygeng@simm.ac.cn" class="auth_mail" title="E-mail the corresponding author} ; Wenhu Duan^a ; ^{whduan@simm.ac.cn" class="auth_mail" title="E-mail the corresponding author}

关键词：Antitumor ; c-Met ; Kinase inhibitor ; Triazolotriazines

刊名：European Journal of Medicinal Chemistry

出版年：2016

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