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在“
Elsevier电子期刊
”中,
命中:
71,572
条,耗时:0.0169916 秒
在所有数据库中总计命中:
135,942
条
1.
Polar aromatic periphery increases
ago
nist potency of spirocyclic free fatty acid receptor (GPR40)
ago
nists inspired by LY2881835
作者:
Mikhail Krasavin
a
;
m.krasavin@spbu.ru
;
Alexey Lukin
b
;
Daria Bagnyukova
b
;
Nikolay Zhurilo
b
;
Aleksei Golovanov
b
;
Sergey Zozulya
c
;
d
;
Ihor Zahanich
c
;
Daniel Moore
e
;
Irina G. Tikhonova
e
关键词:
Drug discovery
;
FFA1
ago
nists
;
Antidiabetic agents
;
Spirocyclic motifs
;
Hydrophobic interactions
;
π&minus
;
π stacking
刊名:European Journal of Medicinal Chemistry
出版年:2017
2.
Dopamine
ago
nist withdrawal syndrome: A comprehensive review
作者:
Xin Xin Yu
;
yux@ccf.org
;
Hubert H Fernandez
关键词:
Parkinson disease
;
Dopamine
ago
nist
;
Dopamine
ago
nist withdrawal syndrome
;
Impulse control disorder
刊名:Journal of the Neurological Sciences
出版年:2017
3.
Novel 5-nitropyrimidine derivatives bearing endo-azabicyclic alcohols/amines as potent GPR119
ago
nists
关键词:
GPR119
ago
nists
;
5-Nitropyrimidine
;
endo-Azabicyclic alcohol
;
Full
ago
nists
刊名:Bioorganic & Medicinal Chemistry
出版年:2017
4.
Molecular dynamics simulation of the human estrogen receptor alpha: contribution to the pharmacophore of the
ago
nists
作者:
Dessislava Jereva
a
;
dessislava.jereva@biomed.bas.bg
;
Filip Fratev
a
;
b
;
fratev@biomed.bas.bg
;
Ivanka Tsakovska
a
;
itsakovska@biomed.bas.bg
;
Petko Alov
a
;
petko.alov@biophys.bas.bg
;
Tania Pencheva
a
;
tania.pencheva@biomed.bas.bg
;
Ilza Pajeva
a
;
pajeva@biomed.bas.bg
关键词:
Human estrogen receptor alpha
;
Ago
nist
;
Pharmacophore
;
Molecular dynamics simulation
刊名:Mathematics and Computers in Simulation
出版年:2017
5.
Discovery, structure-activity relationship studies, and anti-nociceptive effects of N-(1,2,3,4-tetrahydro-1-isoquinolinylmethyl)benzamides as novel opioid receptor
ago
nists
作者:
Sheng-Ren Chen
a
;
c
;
Yi-Yu Ke
a
;
1
;
Teng-Kuang Yeh
a
;
1
;
Shu-Yu Lin
a
;
Li-Chin Ou
a
;
Shu-Chun Chen
a
;
Wan-Ting Chang
a
;
Hsiao-Fu Chang
a
;
Zih-Huei Wu
a
;
Chih-Chien Hsieh
a
;
Ping-Yee Law
b
;
Horace H. Loh
b
;
Chuan Shih
a
;
Yiu-Kay Lai
c
;
yklai@life.nthu.edu.tw
;
Shiu-Hwa Yeh
a
;
d
;
bau9763@bp.nhri.org.tw
;
Shau-Hua Ueng
a
;
shueng@nhri.org.tw
关键词:
μ-opioid receptor
ago
nist
;
κ-opioid receptor
ago
nist
;
Structure-activity relationship
;
Blood-brain barrier
;
Penetration
;
Anti-nociceptive effects
;
Tail-flick test
刊名:European Journal of Medicinal Chemistry
出版年:2017
6.
Inverse
ago
nists - What do they mean for psychiatry?
作者:
David Nutt
a
;
d.nutt@imperial.ac.uk
;
Stephen Stahl
b
;
Pierre Blier
c
;
Filippo Dr
ago
d
;
Joseph Zohar
e
;
Sue Wilson
a
关键词:
Inverse
ago
nist
;
Ant
ago
nist
;
Serotonin
;
5-HT2A
刊名:European Neuropsychopharmacology
出版年:2017
7.
A benzo[b]thiophene-based selective type 4 S1P receptor
ago
nist
作者:
Wooyoung Hur
a
;
1
;
Hugh Rosen
b
;
Nathanael S. Gray
a
;
Nathanael_Gray@dfci.harvard.edu
关键词:
Sphingosine-1-phosphate
;
S1P receptor
;
S1PR4
;
S1P4
;
Selective
ago
nist
刊名:Bioorganic & Medicinal Chemistry Letters
出版年:2017
8.
Estimation of the receptor-state affinity constants of ligands in functional studies using wild type and constitutively active mutant receptors: Implications for estimation of
ago
nist bias
作者:
Frederick J. Ehlert
a
;
b
;
fjehlert@uci.edu
;
Richard S.L. Stein
b
关键词:
Receptor state affinity constants
;
Constitutive activity
;
Ago
nist bias
;
System bias
;
Monod-Wyman-Changeux model
;
Observed affinity
;
Efficacy
;
Receptor activation
;
Active state
;
Inactive state
刊名:Journal of Pharmacological and Toxicological Methods
出版年:2017
9.
Real-world effectiveness and safety of dapagliflozin therapy added to a GLP1 receptor
ago
nist in patients with type 2 diabetes
作者:
J.J. Gorgojo-Martí
;
nez
;
jjgorgojo@fhalcorcon.es
;
C. Serrano-Moreno
cserranom@fhalcorcon.es
;
A. Sanz-Velasco
asanzv@fhalcorcon.es
;
G. Feo-Ortega
gfeo@gmail.com
;
F. Almodó
;
var-Ruiz
falmodovar@fhalcorcon.es
关键词:
GLP1 receptor
ago
nist
;
SGLT-2 inhibitor
;
Type 2 diabetes
刊名:Nutrition, Metabolism and Cardiovascular Diseases
出版年:2017
10.
Potential role for the VDR
ago
nist elocalcitol in metabolic control: Evidences in human skeletal muscle cells
作者:
Cristina Antinozzi
a
;
Clarissa Corinaldesi
a
;
g
;
Carla Giordano
b
;
Annalinda Pisano
b
;
Bruna Cerbelli
b
;
Silvia Migliaccio
a
;
Luigi Di Luigi
a
;
Katia Stefanantoni
c
;
Gabriella Barbara Vannelli
d
;
Salvatore Minisola
e
;
Guido Valesini
c
;
Valeria Riccieri
c
;
Andrea Lenzi
f
;
Clara Crescioli
a
;
clara.crescioli@uniroma4.it
关键词:
VDR
ago
nist
;
Metabolism
;
Inflammatory myopathy
;
Human skeletal muscle cells
刊名:The Journal of Steroid Biochemistry and Molecular Biology
出版年:2017
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