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在“Elsevier电子期刊”中，命中：110条，耗时：0.0140238 秒

在所有数据库中总计命中：485条

1.Dual inhibition of BACE1 and Aβ aggregation by β-ecdysone: Application of a phytoecdysteroid scaffold in Alzheimer’s disease therapeutics

作者：Sandipan Chakraborty¹ ; ^{sandipanchakraborty.13@gmail.com} ; Soumalee Basu ; ^{soumalee@gmail.com}

关键词：AD therapeutics ; BACE1 ; Aβ aggregation ; Steady-state and time-resolved fluorescence ; Molecular modeling ; AFM

刊名：International Journal of Biological Macromolecules

出版年：2017

2.Neuritogenic activity of bi-functional bis-tryptoline triazole

作者：Jutamas Jiaranaikulwanitch^a ; ^b ; ^{jutamas.jia@cmu.ac.th} ; Sarin Tadtong^c ; Piyarat Govitrapong^d ; Valery V. Fokin^e ; Opa Vajragupta^b

关键词：Bis-tryptoline triazole ; Multifunctional activity ; Neuritogenic activity ; β-secretase inhibitor ; β-amyloid aggregation

刊名：Bioorganic & Medicinal Chemistry

出版年：2017

3.HIV Protease Inhibitors Alter Amyloid Precursor Protein Processing via β-Site Amyloid Precursor Protein Cleaving Enzyme-1 Translational Up-Regulation

作者：Patrick J. Gannon^&lowast ; ; ^&dagger ; ; Cagla Akay-Espinoza^&dagger ; ; Alan C. Yee^&dagger ; ; Lisa A. Briand^&Dagger ; ; Michelle A. Erickson^&dagger ; ; Benjamin B. Gelman^§ ; ; Yan Gao^¶ ; ; Norman J. Haughey^‖ ; M. Christine Zink^&lowast ; &lowast ; ; Janice E. Clements^&lowast ; &lowast ; ; Nicholas S. Kim^&dagger ; ; Gabriel Van De Walle^&dagger ; ; Brigid K. Jensen^&dagger ; ; Robert Vassar^&dagger ; &dagger ; ; R. Christopher Pierce^&Dagger ; &Dagger ; ; Alexander J. Gill^§ ; § ; ; Dennis L. Kolson^§ ; § ; ; J. Alan Diehl^¶ ; ; Joseph L. Mankowski^‖ ; Kelly L. Jordan-Sciutto^&dagger ; ; ^{jordank@upenn.edu}

刊名：The American Journal of Pathology

出版年：2017

4.4-O-galloylalbiflorin discovered from Paeonia lactiflora Pall. is a potential β-site amyloid precursor protein cleaving enzyme 1 (BACE1) inhibitor

作者：Xiao-Long Hu^a ; ^b ; ¹ ; Ye-Bo Li^a ; ¹ ; Song Qi^b ; Qiao Zhang^b ; Tian-Shu Ren^a ; Wei-Hong Meng^a ; ^{weihongmeng_edu@163.com} ; Qing-Chun Zhao^a ; ^{zhaoqingchun1967@163.com}

关键词：Alzheimer's disease (AD) ; β-secretase (BACE1) ; β-amyloid peptide ; Paeonia lactiflora Pall ; 4-O-galloylalbiflorin ; Docking

刊名：Journal of Functional Foods

出版年：2016

5.Discovery of furo[2,3-d][1,3]thiazinamines as beta amyloid cleaving enzyme-1 (BACE1) inhibitors

作者：Yong-Jin Wu^a ; ^{Yong-Jin.Wu@bms.com" class="auth_mail" title="E-mail the corresponding author} ; Jason Guernon^a ; Ramkumar Rajamani^a ; Jeremy H. Toyn^a ; ^&dagger ; ; Michael K. Ahlijanian^a ; Charles F. Albright^a ; Jodi Muckelbauer^b ; ChiehYing Chang^b ; Dan Camac^b ; John E. Macor^b ; Lorin A. Thompson^a

关键词：BACE1 inhibitor ; Furo[2 ; 3-d][1 ; 3]thiazinamine ; Alzheimer&rsquo ; s disease

刊名：Bioorganic & Medicinal Chemistry Letters

出版年：2016

6.Gastrodin suppresses BACE1 expression under oxidative stress condition via inhibition of the PKR/eIF2α pathway in Alzheimer’s disease

作者：J.-S. Zhang^a ; ^&dagger ; ; S.-F. Zhou^a ; ^&dagger ; ; Q. Wang^a ; J.-N. Guo^a ; H.-M. Liang^a ; J.-B. Deng^a ; ^b ; ^{dengjinbohn@163.com" class="auth_mail" title="E-mail the corresponding author} ; W.-Y. He^a ; ^{hewy001@126.com" class="auth_mail" title="E-mail the corresponding author}

关键词：AD ; Alzheimer&rsquo ; s disease ; Aβ ; β-amyloid protein ; BACE1 ; β-site APP-cleaving enzyme 1 ; CAT ; catalase ; eIF2α ; Eukaryotic initiation factor-2α ; Gas ; gastrodin ; H2O2 ; hydrogen peroxide ; MDA ; malondialdehyde ; NF-κB ; nuclear factor-κB ; PKR/eIF2 ; αprotein kinase/Eukaryotic initiation factor-2α ; PRI ; PKR inhibitor ; SD ; standard deviation ; SOD ; superoxide dismutase

刊名：Neuroscience

出版年：2016

7.Design and synthesis of 5-cyclopropyl substituted cyclic acylguanidine compounds as BACE1 inhibitors

作者：Jia-Kuo Liu ; Wei Gu ; Xiao-Rui Cheng ; Jun-Ping Cheng ; Ai-Hua Nie ; ^{ahnie512@163.com" class="auth_mail" title="E-mail the corresponding author} ; Wen-Xia Zhou ; ^{zhouwx@nic.bmi.ac.cn" class="auth_mail" title="E-mail the corresponding author}

关键词：Alzheimer's disease ; BACE1 inhibitor ; β-Secretase ; Drug discovery ; Cyclic acylguanidine

刊名：Chinese Chemical Letters

出版年：2016

8.Design and synthesis of 3′-(prop-2-yn-1-yloxy)-biphenyl substituted cyclic acylguanidine compounds as BACE1 inhibitors

关键词：Alzheimer's disease ; BACE1 inhibitor ; Prop-2-yn-1-yloxy ; Cyclic acylguanidine

刊名：Chinese Chemical Letters

出版年：2016

9.Profiling the dynamics of CSF and plasma Aβ reduction after treatment with JNJ-54861911, a potent oral BACE inhibitor

作者：Maarten Timmers^a ; ^b ; ¹ ; Bianca Van Broeck^a ; ¹ ; Steven Ramael^c ; John Slemmon^d ; Katja De Waepenaert^a ; Alberto Russu^a ; Jennifer Bogert^e ; Hans Stieltjes^a ; Leslie M. Shaw^f ; Sebastiaan Engelborghs^b ; ^g ; Dieder Moechars^a ; Marc Mercken^a ; Enchi Liu^d ; Vikash Sinha^h ; John Kemp^a ; Luc Van Nueten^a ; Luc Tritsmans^a ; Johannes Rolf Streffer^a ; ^b ; ^{jstreffe@its.jnj.com" class="auth_mail" title="E-mail the corresponding author}

关键词：JNJ-54861911 ; Alzheimer's disease ; Amyloid β ; β-secretase enzyme ; BACE1 ; BACE inhibitors

刊名：Alzheimer's & Dementia: Translational Research & Clinical Interventions

出版年：2016

10.Alzheimer’s therapy targeting the β-secretase enzyme BACE1: Benefits and potential limitations from the perspective of animal model studies

作者：Masuo Ohno^a ; ^b ; ^{mohno@nki.rfmh.org" class="auth_mail" title="E-mail the corresponding author}

关键词：Alzheimer&rsquo ; s disease ; β-Secretase ; BACE1 ; Learning and memory ; Synaptic function ; Mouse model

刊名：Brain Research Bulletin

出版年：2016

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