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在“Elsevier电子期刊”中，命中：50条，耗时：小于0.01 秒

在所有数据库中总计命中：149条

1.Clk1 deficiency promotes neuroinflammation and subsequent dopaminergic cell death through regulation of microglial metabolic reprogramming

作者：Ruinan Gu^a ; Fali Zhang^a ; Gang Chen^b ; Chaojun Han^a ; Jay Liu^b ; Zhaoxiang Ren^a ; Yi Zhu^a ; John L. Waddington^a ; ^c ; Long Tai Zheng^a ; ^{zhenglongtai@suda.edu.cn} ; Xuechu Zhen^a ; ^{xuechuzhen@suda.edu.cn}

关键词：Clk1 ; Microglia ; Glycolysis ; MPTP ; mTOR/HIF-1α

刊名：Brain, Behavior, and Immunity

出版年：2017

2.Novel CLK1 inhibitors based on N-aryloxazol-2-amine skeleton - A possible way to dual VEGFR2 TK/CLK ligands

作者：Miroslav Murá ; r^a ; Juraj Dobia&scaron ; ^a ; Peter &Scaron ; ramel^a ; ^c ; Gabriela Addová ; ^b ; Gilles Hanquet^c ; Andrej Bohá ; č^a ; ^d ; ^{andrej.bohac@fns.uniba.sk}

关键词：Dual CLK1/VEGFR2 kinase ligands ; CDK9 ; GSK3 ; DYRK1A ; GSK3α/β ; Muti-targeted kinase inhibitors

刊名：European Journal of Medicinal Chemistry

出版年：2017

3.Nerve Growth Factor Promotes Gastric Tumorigenesis through Aberrant Cholinergic Signaling

作者：Yoku Hayakawa¹ ; ² ; ¹² ; Kosuke Sakitani¹ ; ¹² ; Mitsuru Konishi² ; Samuel Asfaha¹ ; ³ ; Ryota Niikura² ; Hiroyuki Tomita⁴ ; Bernhard W. Renz¹ ; ⁵ ; Yagnesh Tailor¹ ; Marina Macchini¹ ; Moritz Middelhoff¹ ; Zhengyu Jiang¹ ; Takayuki Tanaka¹ ; Zinaida A. Dubeykovskaya¹ ; Woosook Kim¹ ; Xiaowei Chen¹ ; Aleksandra M. Urbanska¹ ; Karan Nagar¹ ; Christoph B. Westphalen¹ ; ⁶ ; Michael Quante⁷ ; Chyuan-Sheng Lin⁸ ; ⁹ ; Michael D. Gershon⁸ ; Akira Hara⁴ ; Chun-Mei Zhao¹⁰ ; Duan Chen¹⁰ ; Daniel L. Worthley¹ ; ¹¹ ; Kazuhiko Koike² ; Timothy C. Wang¹ ; ¹³ ; ^{tcw21@columbia.edu}

关键词：NGF ; gastric cancer ; acetylcholine ; Lgr5 ; wnt ; YAP ; Dclk1 ; tuft cell ; stem cell ; muscarinic acetylcholine receptor type 3

刊名：Cancer Cell

出版年：2017

4.miR-613 inhibits the growth and invasiveness of human hepatocellular carcinoma via targeting DCLK1

作者：Wenyao Wang ; ^{wangwy117@163.com" class="auth_mail" title="E-mail the corresponding author} ; Hongfei Zhang ; Lichao Wang ; Shaojun Zhang ; Miao Tang

关键词：Dysregulation ; Growth ; Invasiveness ; microRNA ; Target

刊名：Biochemical and Biophysical Research Communications

出版年：2016

5.Systematic diversification of benzylidene heterocycles yields novel inhibitor scaffolds selective for Dyrk1A, Clk1 and CK2

作者：Marica Mariano^a ; Rolf W. Hartmann^a ; ^b ; Matthias Engel^a ; ^{ma.engel@mx.uni-saarland.de" class="auth_mail" title="E-mail the corresponding author}

关键词：Dyrk1A ; PI3 kinase ; Alzheimer ; Glioma ; Multi-targeted inhibitor

刊名：European Journal of Medicinal Chemistry

出版年：2016

6.Synthesis, biological evaluation and molecular modeling studies of imidazo[1,2-a]pyridines derivatives as protein kinase inhibitors

作者：Marie Lawson^a ; Jordi Rodrigo^a ; Blandine Baratte^b ; Thomas Robert^b ; Claire Delehouzé ; ^b ; Olivier Lozach^b ; Sandrine Ruchaud^b ; Sté ; phane Bach^b ; Jean-Daniel Brion^a ; Mouad Alami^a ; ; Abdallah Hamze^a ; ^{abdallah.hamze@u-psud.fr" class="auth_mail" title="E-mail the corresponding author}

关键词：CLK1 ; DYRK1A ; Kinase inhibitors ; Imidazo[1 ; 2-a]pyridines

刊名：European Journal of Medicinal Chemistry

出版年：2016

7.Release of SR Proteins from CLK1 by SRPK1: A Symbiotic Kinase System for Phosphorylation Control of Pre-mRNA Splicing

作者：Brandon E. Aubol¹ ; Guowei Wu² ; Malik M. Keshwani¹ ; Maliheh Movassat³ ; Laurent Fattet¹ ; Klemens J. Hertel³ ; Xiang-Dong Fu² ; Joseph A. Adams¹ ; ^{j2adams@ucsd.edu" class="auth_mail" title="E-mail the corresponding author}

刊名：Molecular Cell

出版年：2016

8.Discovery of pyrido[3,4-g]quinazoline derivatives as CMGC family protein kinase inhibitors: Design, synthesis, inhibitory potency and X-ray co-crystal structure

作者：Yannick J. Esvan^a ; ^b ; ¹ ; Wael Zeinyeh^a ; ^b ; ¹ ; Thibaut Boibessot^a ; ^b ; Lionel Nauton^a ; ^b ; Vincent Thé ; ry^a ; ^b ; Stefan Knapp^c ; ^d ; Apirat Chaikuad^c ; ^d ; Nadè ; ge Loaë ; c^e ; Laurent Meijer^e ; Fabrice Anizon^a ; ^b ; Francis Giraud^a ; ^b ; ^{Francis.GIRAUD@univ-bpclermont.fr" class="auth_mail" title="E-mail the corresponding author} ; Pascale Moreau^a ; ^b ; ^{Pascale.MOREAU@univ-bpclermont.fr" class="auth_mail" title="E-mail the corresponding author}

关键词：Pyrido[3 ; 4-g]quinazoline ; Kinase inhibitors ; Ser/Thr kinases ; CMGC family ; CLK1 binding mode

刊名：European Journal of Medicinal Chemistry

出版年：2016

9.Su1996 FOXD3 Is a Novel Negative Regulator of Intronv(β)-Promoter Within hDCLK1-Gene in Normal Colonic Cells, But Gets Epigenetically Silenced in hCRCs, Resulting in the Expression of a Short Isoform of DCLK1 (DCLK1-S): Prognostic/Diagnostic Implications

作者：Malaney R. O'Connell ; Shubhashish Sarkar ; Gurinder Luthra ; Yoshinaga Okugawa ; Yuji Toiyama ; Denise Ward ; Ajay Goel ; Pomila Singh

刊名：Gastroenterology

出版年：2016

10.Synthesis and preliminary in vitro kinase inhibition evaluation of new diversely substituted pyrido[3,4-g]quinazoline derivatives

作者：Wael Zeinyeh^a ; ^b ; Yannick J. Esvan^a ; ^b ; Lionel Nauton^a ; ^b ; Nadè ; ge Loaë ; c^c ; Laurent Meijer^c ; Vincent Thé ; ry^a ; ^b ; Fabrice Anizon^a ; ^b ; Francis Giraud^a ; ^b ; ^{Francis.GIRAUD@univ-bpclermont.fr" class="auth_mail" title="E-mail the corresponding author} ; Pascale Moreau^a ; ^b ; ^{Pascale.MOREAU@univ-bpclermont.fr" class="auth_mail" title="E-mail the corresponding author}

关键词：Pyrido[3 ; 4-g]quinazoline ; Protein kinase inhibition ; CLK1 ; DYRK1A ; CDK5 ; GSK3 ; CK1

刊名：Bioorganic & Medicinal Chemistry Letters

出版年：2016

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