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CNKI学位论文(731)
知网期刊论文(99)
在“
Elsevier电子期刊
”中,
命中:
162
条,耗时:0.0119909 秒
在所有数据库中总计命中:
830
条
1.
(5aR)-5a-C-Pentyl-4-epi-isofagomine: A powerful inhibitor of lysosomal β-
galactosidase
and a remarkable chaperone for mutations associated with GM1-gangliosidosis and Morquio disease type B
作者:
Sophie Front
a
;
Anna Biela-Banaś
a
;
Patricie Burda
b
;
Diana Ballhausen
c
;
Katsumi Higaki
d
;
Anna Caciotti
e
;
Amelia Morrone
e
;
f
;
Julie Charollais-Thoenig
g
;
Estelle Gallienne
a
;
Sté
;
phane Demotz
g
;
Olivier R. Martin
a
;
olivier.martin@univ-orleans.fr
关键词:
Galactosidase
inhibitors
;
GM1-gangliosidosis
;
Morquio disease type B
;
Iminosugars
;
Pharmacological chaperones
刊名:European Journal of Medicinal Chemistry
出版年:2017
2.
Strategy for designing selective α-l-rhamnosidase
inhibitors
: Synthesis and biological evaluation of l-DMDP cyclic isothioureas
作者:
Shota Miyawaki
a
;
Yuki Hirokami
a
;
Kyoko Kinami
a
;
Masako Hoshino
a
;
Daisuke Minehira
a
;
Daiki Miyamoto
b
;
Robert J. Nash
c
;
George W.J. Fleet
d
;
Isao Adachi
a
;
Naoki Toyooka
b
;
Atsushi Kato
a
;
关键词:
α-l-Rhamnosidase
;
l-DMDP cyclic isothiourea
;
Iminosugars
;
Structure&ndash
;
activity relationships
;
Glycosidase inhibitor
;
Mycobacterium tuberculosis
刊名:Bioorganic & Medicinal Chemistry
出版年:2017
3.
Synthesis of C-5a-substituted derivatives of 4-epi-isofagomine: notable β-
galactosidase
inhibitors
and activity promotors of G
M1
-gangliosidosis related human lysosomal β-
galactosidase
mutant R201C
作者:
Martin Thonhofer
a
;
Patrick Weber
a
;
Andres Gonzalez Santana
b
;
Christina Tysoe
b
;
Roland Fischer
c
;
Bettina M. Pabst
d
;
Eduard Paschke
d
;
Michael Schalli
a
;
Arnold E. Stü
;
tz
a
;
stuetz@tugraz.at" class="auth_mail" title="E-mail the corresponding author
;
Marion Tschernutter
d
;
Werner Windischhofer
d
;
Stephen G. Withers
b
关键词:
Iminoalditol
;
4-Epi-isofagomine
;
Galactosidase
inhibitor
;
Pharmacological chaperone
;
GM1-gangliosidosis
刊名:Carbohydrate Research
出版年:2016
4.
Synthesis of C-5a-chain extended derivatives of 4-epi-isofagomine: Powerful β-
galactosidase
inhibitors
and low concentration activators of G
M1
-gangliosidosis-related human lysosomal β-
galactosidase
作者:
Martin Thonhofer
a
;
Patrick Weber
a
;
Andres Gonzalez Santana
b
;
Roland Fischer
c
;
Bettina M. Pabst
d
;
Eduard Paschke
d
;
Michael Schalli
a
;
Arnold E. Stü
;
tz
a
;
stuetz@tugraz.at" class="auth_mail" title="E-mail the corresponding author
;
Marion Tschernutter
d
;
Werner Windischhofer
d
;
Stephen G. Withers
b
关键词:
Iminoalditol
;
4-epi-Isofagomine
;
Galactosidase
inhibitor
;
Pharmacological chaperone
;
GM1-gangliosidosis
刊名:Bioorganic & Medicinal Chemistry Letters
出版年:2016
5.
5-Fluoro derivatives of 4-epi-isofagomine as d-
galactosidase
inhibitors
and potential pharmacological chaperones for G
M1
-gangliosidosis as well as Fabry's disease
作者:
Martin Thonhofer
a
;
Andres Gonzalez Santana
b
;
Roland Fischer
c
;
Ana Torvisco Gomez
c
;
Robert Saf
d
;
Michael Schalli
a
;
Arnold E. Stü
;
tz
a
;
stuetz@tugraz.at" class="auth_mail" title="E-mail the corresponding author
;
Stephen G. Withers
b
关键词:
Iminoalditol
;
Fluorosugar
;
Galactosidase
inhibitor
;
Pharmacological chaperone
;
Fabry's disease
;
GM1-gangliosidosis
刊名:Carbohydrate Research
出版年:2016
6.
Illuminating the binding interactions of galactonoamidines during the inhibition of β-
galactosidase
(E. coli)
作者:
Qiu-Hua Fan
;
Jessica B. Pickens
;
Susanne Striegler
;
Susanne.striegler@uark.edu" class="auth_mail" title="E-mail the corresponding author
;
Cé
;
dric D. Gervaise
关键词:
Glycosidase
;
Inhibition
;
H-bonding
;
Carbohydrate
刊名:Bioorganic & Medicinal Chemistry
出版年:2016
7.
Comparison of three quantification methods for the TZM-bl pseudovirus assay for screening of anti-HIV-1 agents
作者:
Liying Xing
;
Shunyi Wang
;
Qin Hu
;
hq07616@bjut.edu.cn" class="auth_mail" title="E-mail the corresponding author
;
Jingtao Li
;
Yi Zeng
关键词:
TZM-bl
;
HIV-1 pseudovirus
;
Luciferase
;
β-
galactosidase
刊名:Journal of Virological Methods
出版年:2016
8.
Inhibition of autophagy enhances effects of PF-04691502 on apoptosis and DNA damage of lung cancer cells
作者:
Hong-Rong Fei
a
;
1
;
Hua- Tian
b
;
1
;
Xiao-Lei Zhou
c
;
Ming-Feng Yang
d
;
Bao-Liang Sun
d
;
Xiao-Yi Yang
d
;
xyyang@tsmc.edu.cn" class="auth_mail" title="E-mail the corresponding author
;
Peng- Jiao
b
;
jiaopeng196@163.com" class="auth_mail" title="E-mail the corresponding author
;
Feng-Ze Wang
d
;
e
;
fengzewang@gmail.com" class="auth_mail" title="E-mail the corresponding author
关键词:
PI3
;
K/mTOR
;
PF-04691502
;
Apoptosis
;
DNA damage
;
Autophagy
刊名:International Journal of Biochemistry and Cell Biology
出版年:2016
9.
Compound profiling and 3D-QSAR studies of hydrazone derivatives with activity against intracellular Trypanosoma cruzi
作者:
Lí
;
via Bandeira Costa
a
;
&dagger
;
;
Marcos Verí
;
ssimo de Oliveira Cardoso
a
;
&dagger
;
;
Gevanio Bezerra de Oliveira Filho
a
;
Paulo André
;
Teixeira de Moraes Gomes
a
;
José
;
Wanderlan Pontes Espí
;
ndola
a
;
Thays Gabrielle de Jesus Silva
a
;
Pedro Henrique Monteiro Torres
b
;
Floriano Paes Silva Junior
b
;
Julio Martin
c
;
Regina Cé
;
lia Bressan Queiroz de Figueiredo
d
;
Ana Cristina Lima Leite
a
;
acllb2003@yahoo.com.br" class="auth_mail" title="E-mail the corresponding author
关键词:
Chagas disease
;
Hydrazones
;
Thiosemicarbazones
;
Thiazoles
;
3D-QSAR
;
Drug design
刊名:Bioorganic & Medicinal Chemistry
出版年:2016
10.
Superiority of the S,S conformation in diverse pharmacological processes: Intestinal transport and entry inhibition activity of novel anti-HIV drug lead
作者:
Joseph Fanous
a
;
1
;
Avi Swed
a
;
1
;
Salim Joubran
b
;
1
;
Mattan Hurevich
b
;
Elena Britan-Rosich
c
;
Moshe Kotler
c
;
Chaim Gilon
b
;
Amnon Hoffman
a
;
amnonh@ekmd.huji.ac.il" class="auth_mail" title="E-mail the corresponding author
关键词:
MAGI
;
the multinuclear activation of a
galactosidase
indicator
;
HIV-1
;
human immunodeficiency virus
;
gp-120
;
P-glycoprotein 120
;
BC
;
backbone cyclization
;
PK
;
pharmacokinetic
;
PD
;
pharmacodynamics
;
cm
;
centimeter
;
s
;
seconds
;
渭l
;
microliter
;
Papp
;
the permeability coefficient
;
dQ/dt
;
the steady state rate of appearance of the drug on the receiver side
;
C0
;
the initial concentration of the drug at the donor side
;
A
;
the surface area
刊名:International Journal of Pharmaceutics
出版年:2015
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