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CNKI学位论文(58)
知网期刊论文(37)
在“
Elsevier电子期刊
”中,
命中:
30
条,耗时:小于0.01 秒
在所有数据库中总计命中:
95
条
1.
Structure-activity relationships of 4-hydroxy-4-biaryl-proline acylsulfonamide tripeptides: A series of potent NS3
protease
inhibitors
for the treatment of hepatitis C virus
作者:
Alan Xiangdong Wang
a
;
alan.wang@bms.com
;
Jie Chen
a
;
Qian Zhao
a
;
Li-Qiang Sun
a
;
Jacques Friborg
b
;
Fei Yu
b
;
Dennis Hernandez
b
;
Andrew C. Good
c
;
Herbert E. Klei
c
;
Ramkumar Rajamani
c
;
Kathy Mosure
d
;
Jay O. Knipe
d
;
Danshi Li
d
;
Jialong Zhu
d
;
Paul C. Levesque
d
;
Fiona McPhee
b
;
Nicholas A. Meanwell
a
;
Paul M. Scola
a
;
关键词:
HCV
NS3/4A
serine
protease
inhibitors
;
Tripeptide acylsulfonamides
;
C4 aryl
;
C4 hydroxy-proline
;
Potent and orally bioavailable
;
Cardiovascular profiles
刊名:Bioorganic & Medicinal Chemistry Letters
出版年:2017
2.
Discovery and structural diversity of the hepatitis C virus NS3/4A
serine
protease
inhibitor series leading to clinical candidate IDX320
作者:
Christophe C. Parsy
a
;
christophe.parsy@merck.com" class="auth_mail" title="E-mail the corresponding author
;
Franç
;
ois-René
;
Alexandre
a
;
Valé
;
rie Bidau
a
;
&dagger
;
;
Florence Bonnaterre
a
;
&dagger
;
;
Guillaume Brandt
a
;
Catherine Caillet
a
;
&dagger
;
;
Sylvie Cappelle
a
;
Dominique Chaves
a
;
&dagger
;
;
Thierry Convard
a
;
Michel Derock
a
;
&dagger
;
;
Damien Gloux
a
;
&dagger
;
;
Yann Griffon
a
;
&dagger
;
;
Lisa B. Lallos
b
;
&dagger
;
;
Frederic Leroy
a
;
&dagger
;
;
Michel Liuzzi
b
;
&dagger
;
;
Anna-Giulia Loi
b
;
&dagger
;
;
Laure Moulat
a
;
&dagger
;
;
Musiu Chiara
b
;
&dagger
;
;
Houcine Rahali
a
;
Virginie Roques
a
;
&dagger
;
;
Elodie Rosinovsky
a
;
&dagger
;
;
Simon Savin
a
;
&dagger
;
;
Maria Seifer
b
;
David Standring
b
;
&dagger
;
;
Dominique Surleraux
a
;
&dagger
;
关键词:
Hepatitis C
;
HCV
NS3/4A
protease
inhibitors
;
Macrocycle
刊名:Bioorganic & Medicinal Chemistry Letters
出版年:2015
3.
Discovery of novel P3-oxo inhibitor of hepatitis C virus NS3/4A
serine
protease
作者:
Maosheng Duan
a
;
duanmaosheng@hdbiosciences.com
;
Wieslaw Kazmierski
a
;
wieslaw.m.kazmierski@gsk.com
;
Renae Crosby
a
;
Margaret Gartland
a
;
Jinjing Ji
a
;
Matt Tallant
a
;
Amy Wang
a
;
Robert Hamatake
a
;
Lois Wright
a
;
Min Wu
a
;
Yong-Kang Zhang
b
;
Charles Z. Ding
b
;
Xianfeng Li
b
;
Yang Liu
b
;
Suoming Zhang
b
;
Yasheen Zhou
b
;
Jacob J. Plattner
b
;
Stephen J. Baker
b
关键词:
HCV
;
HCV
protease
;
HCV
protease
inhibitor
;
Inhibitor
刊名:Bioorganic and Medicinal Chemistry Letters
出版年:2012
4.
Molecular modeling study on the resistance mechanism of
HCV
NS3/4A
serine
protease
mutants R155K, A156V and D168A to TMC435
作者:
Weiwei Xue
a
;
Dabo Pan
b
;
Ying Yang
a
;
Huanxiang Liu
b
;
hxliu@lzu.edu.cn
;
Xiaojun Yao
a
;
c
;
xjyao@lzu.edu.cn
关键词:
HCV
NS3/4A
protease
;
TMC435
;
Drug resistance
;
Substrate envelope
;
Molecular dynamics simulations
刊名:Antiviral Research
出版年:2012
5.
Chutes and ladders in hepatitis C nucleoside drug development
作者:
Steven J. Coats
;
Ethel C. Garnier-Amblard
;
Franck Amblard
;
Maryam Ehteshami
;
Sheida Amiralaei
;
Hongwang Zhang
;
Longhu Zhou
;
Sebastien R.L. Boucle
;
Xiao Lu
;
Lavanya Bondada
;
Jadd R. Shelton
;
Hao Li
;
Peng Liu
;
Chengwei Li
;
Jong Hyun Cho
;
Satish N. Chavre
;
Shaoman Zhou
;
Judy Mathew
;
Raymond F. Schinazi
关键词:
HCV
;
Nucleoside analog
;
Clinical trials
;
Antiviral
;
Prodrug
刊名:Antiviral Research
出版年:February, 2014
6.
Molecular modeling based approach, synthesis and in vitro assay to new indole
inhibitors
of hepatitis C NS3/4A
serine
protease
作者:
Nasser S.M. Ismail
a
;
saadnasser2003@yahoo.com
;
Masao Hattori
b
关键词:
3-Aryl-1-(1
H
-indol-3-yl)-2-propen-1-ones
;
HCV
;
Protease
inhibitor
;
Molecular modeling
刊名:Bioorganic and Medicinal Chemistry
出版年:2011
7.
Bioluminescence imaging of Hepatitis C virus NS3/4A
serine
protease
activity in cells and living animals
作者:
Licui Wang
;
Qiuxia Fu
;
Yafeng Dong
;
Yong Zhou
;
Shuaizheng Jia
;
Juan Du
;
Fang Zhao
;
Yingli Wang
;
Xiaohui Wang
;
Jianchun Peng
;
Shuhua Yang
;
Linsheng Zhan
关键词:
NS3/4A
protease
;
Split firefly luciferase complementation strategy
;
In vivo imaging
刊名:Antiviral Research
出版年:2010
8.
Treatment of chronic hepatitis C patients with the NS3/4A
protease
inhibitor danoprevir (ITMN-191/RG7227) leads to robust reductions in viral RNA: A phase 1b multiple ascending dose study
作者:
Nicole Forestier
1
;
nicole.forestier@kgu.de"" rel=""nofollow
;
forestier@med.uni-frankfurt.de"" rel=""nofollow
;
Dominique Larrey
2
;
Dominique Guyader
3
;
Patrick Marcellin
4
;
Ré
;
gine Rouzier
5
;
Alain Patat
6
;
Patrick Smith
7
;
Williamson Bradford
8
;
Steven Porter
8
;
Lawrence Blatt
8
;
Scott D. Seiwert
8
;
Stefan Zeuzem
1
关键词:
HCV
;
Direct antiviral
;
Protease
inhibitor
;
ITMN-191
;
Danoprevir
刊名:Journal of Hepatology
出版年:2011
9.
Hepatitis C virus NS3/4A with sequence variation at amino-terminus has different
serine
protease
activities and inhibitory activities on IFN-β induction and p53-dependent transcriptional activation
作者:
Xueping Wanga
;
Fujun Lib
;
Motoko Nagano-Fujii
;
Lin Deng
;
Kikumi Kitayamac
;
Hak Hottac
关键词:
hepatitis C virus
;
point mutation
;
activity
;
serine
protease
;
secondary structure
刊名:Journal of Nanjing Medical University
出版年:2009
10.
A comparative analysis of the substrate permissiveness of
HCV
and GBV-B NS3/4A
protease
s reveals genetic evidence for an interaction with NS4B protein during genome replication
作者:
Yann Benureau
;
Lucile Warter
;
Bruce A. Malcolm
;
Annette Martin
关键词:
Hepacivirus
;
Hepatitis C virus
;
GB virus B
;
Protease
;
Substrate specificity
;
Replication
;
Mutagenesis
;
Structural model
;
NS3
;
NS4B
刊名:Virology
出版年:2010
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