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在“Elsevier电子期刊”中，命中：85条，耗时：小于0.01 秒

在所有数据库中总计命中：127条

1.Pyrrolopyrimidine derivatives and purine analogs as novel activators of Multidrug Resistance-associated Protein 1 (MRP1, ABCC1)

作者：Sven Marcel Schmitt¹ ; Katja Stefan¹ ; Michael Wiese ; ^{mwiese@uni-bonn.de}

关键词：ABC ; ATP-binding cassette ; ABCB1 ; synonymous for P-gp ; ABCC1 ; synonymous for MRP1 ; ABCG2 ; synonymous for BCRP ; APT ; attached proton test ; ATP ; adenosine 5&prime ; -triphosphate ; BCECF ; 2&prime ; .7&prime ; -bis(2-carboxyethyl)-5-(and-6)-carboxyfluorescein ; BCPCF ; 3-carboxy-propyl-5-(and-6-)-carboxyfluorescein ; BCRP ; Breast Cancer Resistance Protein ; calcein AM ; calcein acetoxymethyl ester ; δ ; chemical shift in ppm ; DAD ; diode array detector ; DEPT ; distortion less enhancement by polarization transfer

刊名：Biochimica et Biophysica Acta (BBA) - Biomembranes

出版年：2017

2.Balancing potency, metabolic stability and permeability in pyrrolopyrimidine-based EGFR inhibitors

作者：Jin Han^a ; ^b ; ^{Jin.Han@ntnu.no" class="auth_mail" title="E-mail the corresponding author} ; Silje Henriksen^a ; ¹ ; ^{Silje.Henriksen@Jotun.no" class="auth_mail" title="E-mail the corresponding author} ; Kristin G. Nø ; rsett^c ; ^{Kristin.Norsett@ntnu.no" class="auth_mail" title="E-mail the corresponding author} ; Eirik Sundby^b ; ^{Eirik.Sundby@hist.no" class="auth_mail" title="E-mail the corresponding author} ; Bå ; rd Helge Hoff^a ; ^{Bard.Helge.Hoff@chem.ntnu.no" class="auth_mail" title="E-mail the corresponding author}

关键词：EGFR ; Pyrrolopyrimidine ; SAR ; ADME ; Metabolism ; Erlotinib

刊名：European Journal of Medicinal Chemistry

出版年：2016

3.Design, synthesis, assessment, and molecular docking of novel pyrrolopyrimidine (7-deazapurine) derivatives as non-nucleoside hepatitis C virus NS5B polymerase inhibitors

作者：Mosaad S. Mohamed^a ; Amira I. Sayed^a ; Mohammed A. Khedr^b ; Sameh H. Soror^c ; ^d ; ^{sameh_soror@pharm.helwan.edu.eg" class="auth_mail" title="E-mail the corresponding author}

关键词：Antiviral drugs ; HCV ; Molecular modeling ; NS5B polymerase ; Pyrrolopyrimidine

刊名：Bioorganic & Medicinal Chemistry

出版年：2016

4.The discovery of 2,5-isomers of triazole-pyrrolopyrimidine as selective Janus kinase 2 (JAK2) inhibitors versus JAK1 and JAK3

作者：Sun-Mi Lee^a ; Kyoung Bin Yoon^b ; Hyo Jeong Lee^b ; Jiwon Kim^c ; You Kyoung Chung^d ; Won-Jea Cho^e ; Chisato Mukai^f ; Sun Choi^d ; Keon Wook Kang^c ; Sun-Young Han^b ; ^{syhan@gnu.ac.kr" class="auth_mail" title="E-mail the corresponding author} ; Hyojin Ko^g ; ^{kohyojin@gist.ac.kr" class="auth_mail" title="E-mail the corresponding author} ; Yong-Chul Kim^a ; ^g ; ^{yongchul@gist.ac.kr" class="auth_mail" title="E-mail the corresponding author}

关键词：JAK2 ; JAK2V617F ; JAK2 inhibitor ; STAT (signal transducer and activator of transcription) ; 4-(2 ; 5-Triazole)-pyrrolopyrimidine

刊名：Bioorganic & Medicinal Chemistry

出版年：2016

5.77 - Structure-activity relationship of pyrrolopyrimidine derivatives as maternal embryonic leucine zipper kinase inhibitor

作者：S.U. Choi ; P. Chi Hoon ; S. You Hwa ; P. Chul Min ; L. Sunkyung ; S. Jong Whan

刊名：European Journal of Cancer

出版年：2016

6.Ensemble docking-based virtual screening yields novel spirocyclic JAK1 inhibitors

作者：Dá ; vid Bajusz ; Gyö ; rgy G. Ferenczy ; Gyö ; rgy M. Keserű ; ^{keseru.gyorgy@ttk.mta.hu}

关键词：AUC ; area under the (ROC) curve ; EF ; enrichment factor ; FDA ; Food and Drug Administration ; FPR ; false positive rate ; HTVS ; high throughput virtual screening ; JAK ; Janus kinase ; LLE ; lipophilic ligand efficiency ; LELP ; lipophilicity-corrected ligand efficiency ; PME ; particle mesh Ewald [method] ; ROC ; receiver operating characteristic [curve] ; SP ; standard precision ; STAT ; signal transducers and activators of transcription ; TPR ; true positive rate

刊名：Journal of Molecular Graphics and Modelling

出版年：2016

7.In vitro baselining of new pyrrolopyrimidine EGFR-TK inhibitors with Erlotinib

作者：Eirik Sundby^a ; ^{Eirik.Sundby@hist.no" class="auth_mail" title="E-mail the corresponding author} ; Jin Han^a ; ^b ; ^{Jin.han@chem.ntnu.no" class="auth_mail" title="E-mail the corresponding author} ; Svein Jacob Kaspersen^b ; ¹ ; ^{Svein.jacob.kaspersen@chem.ntnu.no" class="auth_mail" title="E-mail the corresponding author} ; Bå ; rd Helge Hoff^b ; ^{bard.helge.hoff@chem.ntnu.no" class="auth_mail" title="E-mail the corresponding author}

关键词：Erlotinib (PubChem CID ; 176870) ; Dasatinib (PubChem CID ; 3062316) ; Lapatinib (PubChem CID ; 208908) ; 2-[[6-[4-(Hydroxymethyl)-2-methoxyphenyl]-7H-pyrrolo[2 ; 3-d]pyrimidin-4-yl]amino]-2-phenylethanol (PubChem CID ; 90466098)

刊名：European Journal of Pharmaceutical Sciences

出版年：2015

8.Optimisation of a 5-[3-phenyl-(2-cyclic-ether)-methyl-ether]-4-aminopyrrolopyrimidine series of IGF-1R inhibitors

作者：Robin A. Fairhurst^a ; ^{robin.fairhurst@novartis.com" class="auth_mail" title="E-mail the corresponding author} ; Thomas H. Marsilje^b ; Stefan Stutz^a ; Andreas Boos^a ; Michel Niklaus^a ; Bei Chen^b ; Songchun Jiang^b ; Wenshuo Lu^b ; Pascal Furet^a ; Clive McCarthy^a ; Fré ; dé ; ric Stauffer^a ; Vito Guagnano^a ; Andrea Vaupel^a ; Pierre-Yves Michellys^b ; Christian Schnell^a ; Sé ; bastien Jeay^a

关键词：Oncology ; Kinase inhibitor ; Insulin-like growth factor receptor-1

刊名：Bioorganic & Medicinal Chemistry Letters

出版年：2016

9.Carbonic anhydrase inhibitors: Synthesis, molecular docking, cytotoxic and inhibition of the human carbonic anhydrase isoforms I, II, IX, XII with novel benzenesulfonamides incorporating pyrrole, pyrrolopyrimidine and fused pyrrolopyrimidine moieties

作者：Mostafa M. Ghorab^a ; ^b ; ^{mmsghorab@yahoo.com" class="auth_mail} ; Mansour S. Alsaid^a ; Mariangela Ceruso^c ; Yassin M. Nissan^d ; Claudiu T. Supuran^c ; ^e ; ^{claudiu.supuran@unifi.it" class="auth_mail}

关键词：Pyrrolopyrimidines ; Sulfonamide ; Cytotoxic activity ; Carbonic anhydrase inhibitors ; Molecular docking

刊名：Bioorganic and Medicinal Chemistry

出版年：15 July 2014

10.Synthesis and biological evaluation of substituted 2-anilino-7H-pyrrolopyrimidines as PDK1 inhibitors

作者：Nathan J. O'Brien ; Martin Brzozowski ; David J.D. Wilson ; Leslie W. Deady ; Belinda M. Abbott ; ^{b.abbott@latrobe.edu.au" class="auth_mail}

关键词：3-Phosphoinositide-dependent kinase 1 (PDK1) ; 2-Anilino-7H-pyrrolopyrimidines ; Inhibitor ; Suzuki cross-coupling ; Buchwald&ndash ; Hartwig cross-coupling

刊名：Tetrahedron

出版年：19 August 2014

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