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CNKI期刊论文0611(1)
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在“
Elsevier电子期刊
”中,
命中:
62
条,耗时:小于0.01 秒
在所有数据库中总计命中:
58
条
1.
Design and synthesis of benzodiazepine analogs as isoform-selective human lysine deacetylase inhibitors
作者:
D. Rajasekhar Reddy
;
Flavio Ballante
;
Nancy J. Zhou
;
Garland R. Marshall
;
garlandm@gmail.com
关键词:
Epigenetics
;
Histone deacetylase (HDAC)
;
Lysine deacetylase (KDAC)
;
Benzodiazepine (BZD)
;
Structure-based drug design (
SBDD
)
刊名:European Journal of Medicinal Chemistry
出版年:2017
2.
Structure-based optimization of 1H-imidazole-2-carboxamides as Axl kinase inhibitors utilizing a Mer mutant surrogate
作者:
Walter Keung
a
;
walter.keung@takeda.com
;
Amogh Boloor
a
;
Jason Brown
a
;
Andre Kiryanov
a
;
Anthony Gangloff
a
;
J. David Lawson
b
;
Robert Skene
b
;
Isaac Hoffman
b
;
Josephine Atienza
c
;
Jason Kahana
c
;
Ron De Jong
c
;
Pamela Farrell
c
;
Deepika Balakrishna
c
;
Petro Halkowycz
c
关键词:
Axl
;
Mer
;
Structure design
;
Oncology design
;
Modeling
;
Crystallography
;
SBDD
刊名:Bioorganic & Medicinal Chemistry Letters
出版年:2017
3.
Discovery of a potent and highly selective transforming growth factor β receptor-associated kinase 1 (TAK1) inhibitor by structure based drug design (
SBDD
)
作者:
Terushige Muraoka
a
;
muraokatrs@chugai-pharm.co.jp" class="auth_mail" title="E-mail the corresponding author
;
Mitsuaki Ide
a
;
Kenji Morikami
a
;
Machiko Irie
b
;
Mitsuaki Nakamura
b
;
Takaaki Miura
b
;
Takayuki Kamikawa
b
;
Masamichi Nishihara
a
;
Hirotaka Kashiwagi
a
关键词:
TAK1
;
SBDD
;
Inhibitor
;
Kinase selectivity
刊名:Bioorganic & Medicinal Chemistry
出版年:2016
4.
Design, synthesis and optimization of novel Alk5 (activin-like kinase 5) inhibitors
作者:
Haixia Wang
;
J. David Lawson
;
Nick Scorah
;
Ruhi Kamran
;
Mark S. Hixon
;
Joy Atienza
;
Douglas R. Dougan
;
Mark Sabat
关键词:
Alk5
;
Inhibitors
;
Activin
;
Kinase
;
Transforming
;
Growth
;
Factor
;
SBDD
刊名:Bioorganic & Medicinal Chemistry Letters
出版年:2016
5.
Novel approach of fragment-based lead discovery applied to renin inhibitors
作者:
Michiko Tawada
a
;
michiko.tawada@takeda.com" class="auth_mail" title="E-mail the corresponding author
;
Shinkichi Suzuki
a
;
Yasuhiro Imaeda
a
;
Hideyuki Oki
a
;
Gyorgy Snell
b
;
Craig A. Behnke
b
;
&dagger
;
;
Mitsuyo Kondo
a
;
Naoki Tarui
a
;
Toshimasa Tanaka
a
;
Takanobu Kuroita
a
;
Masaki Tomimoto
a
关键词:
Fragment-based drug discovery (FBDD)
;
High-throughput synthetic chemistry
;
Structure-based drug design (
SBDD
)
;
Renin inhibitor
;
Crystal structure
刊名:Bioorganic & Medicinal Chemistry
出版年:2016
6.
Recent progress on third generation covalent EGFR inhibitors
作者:
Hengmiao Cheng
a
;
henry.cheng@pfizer.com" class="auth_mail" title="E-mail the corresponding author
;
Sajiv K. Nair
a
;
Brion W. Murray
b
关键词:
EGFR
;
Covalent inhibitor
;
T790M
;
Oncogenic mutation
;
Lung cancer
;
NSCLC
;
SBDD
;
Drug resistance
刊名:Bioorganic & Medicinal Chemistry Letters
出版年:2016
7.
Novel drug design for Chagas disease via targeting Trypanosoma cruzi tubulin: Homology modeling and binding pocket prediction on Trypanosoma cruzi tubulin polymerization inhibition by naphthoquinone derivatives
作者:
Charles O. Ogindo
a
;
Mozna H. Khraiwesh
b
;
Matthew George Jr.
c
;
Yakini Brandy
a
;
Nailah Brandy
a
;
Ayele Gugssa
b
;
Mohammad Ashraf
d
;
Muneer Abbas
e
;
f
;
William M. Southerland
c
;
Clarence M. Lee
b
;
Oladapo Bakare
a
;
Yayin Fang
c
;
关键词:
Chagas disease
;
Trypanosoma cruzi
;
Naphthoquinone derivatives
;
Tubulin polymerization inhibition
;
Homology modeling
;
Binding site prediction
;
Structure based drug design (
SBDD
)
刊名:Bioorganic & Medicinal Chemistry
出版年:2016
8.
Discovery of potent, reversible MetAP2 inhibitors via fragment based drug discovery and structure based drug design—Part 2
作者:
Christopher McBride
a
;
;
Zacharia Cheruvallath
a
;
Mallareddy Komandla
a
;
Mingnam Tang
a
;
Pamela Farrell
b
;
J. David Lawson
c
;
Darin Vanderpool
b
;
Yiqin Wu
b
;
Douglas R. Dougan
d
;
Artur Plonowski
b
;
Corine Holub
b
;
Chris Larson
b
关键词:
Methionine aminopeptidase-2
;
MetAP2
;
Metalloprotease
;
Fragment-based drug discovery
;
FBDD
;
Structure-based drug design
;
SBDD
;
Pyrazolo[4
;
3-b]indoles
刊名:Bioorganic & Medicinal Chemistry Letters
出版年:2016
9.
Design and synthesis of potent and selective pyridazin-4(1H)-one-based PDE10A inhibitors interacting with Tyr683 in the PDE10A selectivity pocket
作者:
Masato Yoshikawa
;
masato.yoshikawa@takeda.com" class="auth_mail" title="E-mail the corresponding author
;
Takenori Hitaka
;
Tomoaki Hasui
;
Makoto Fushimi
;
Jun Kunitomo
;
Hironori Kokubo
;
Hideyuki Oki
;
Kosuke Nakashima
;
Takahiko Taniguchi
关键词:
Phosphodiesterase 10A
;
PDE10A
;
Inhibitors
;
Schizophrenia
;
SBDD
刊名:Bioorganic & Medicinal Chemistry
出版年:2016
10.
Optimization of the phenylurea moiety in a phosphoinositide 3-kinase (PI3K) inhibitor to improve water solubility and the PK profile by introducing a solubilizing group and ortho substituents
作者:
Hatsuo Kawada
a
;
kawadahto@chugai-pharm.co.jp" class="auth_mail" title="E-mail the corresponding author
;
Hirosato Ebiike
b
;
Masao Tsukazaki
b
;
Shun Yamamoto
b
;
Kohei Koyama
a
;
Mitsuaki Nakamura
b
;
Kenji Morikami
a
;
Kiyoshi Yoshinari
b
;
Miyuki Yoshida
b
;
Kotaro Ogawa
a
;
Nobuo Shimma
b
;
Takuo Tsukuda
b
;
Jun Ohwada
b
关键词:
PI3K
;
Cancer
;
SBDD
;
Molecular planarity
;
Solubility
;
Pharmacokinetic profile
刊名:Bioorganic & Medicinal Chemistry
出版年:2016
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