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在“
ACS电子期刊
”中,
命中:
17
条,耗时:0.0419812 秒
在所有数据库中总计命中:
679
条
1.
Multiparameter Lead Optimization to Give an Oral
C
he
c
kpoint Kinase 1 (CHK1) Inhibitor Clini
c
al Candidate: (R)-5-((4-((Morpholin-2-ylmethyl)amino)-5-(trifluoromethyl)pyridin-2-yl)amino)pyrazine-2-
c
arbonitrile (CCT245737)
作者:
James D. Osborne
;
Thomas P. Matthews
;
Tatiana M
c
Hardy
;
Ni
c
olas Proisy
;
Kwai-Ming J.
C
heung
;
Mi
c
hael Lain
c
hbury
;
Nathan Brown
;
Mi
c
hael I. Walton
;
Paul D. Eve
;
Katherine J. Boxall
;
Angela Hayes
;
Alan T. Henley
;
Melanie R. Valenti
;
Alexis K. De Haven Brandon
;
Gary Box
;
Yann Jamin
;
Simon P. Robinson
;
Isaa
c
M. Westwood
;
Rob L. M. van Montfort
;
Philip M. Leonard
;
Marieke B. A.
C
. Lamers
;
John
C
.
Reader
;
G. Wynne Aherne
;
Floren
c
e I. Raynaud
;
Suzanne A. E
cc
les
;
Mi
c
helle D. Garrett
;
Ian
C
ollins
刊名:Journal of Medi
c
inal Chemistry
出版年:2016
2.
Thermal
C
ontrast Amplifi
c
ation
Reader
Yielding 8-Fold Analyti
c
al Improvement for Disease Dete
c
tion with Lateral Flow Assays
作者:
Yiru Wang
;
Zhenpeng Qin
;
David R. Boulware
;
Bobbi S. Pritt
;
Lynne M. Sloan
;
Iveth J. González
;
David Bell
;
Roxanne R. Rees-
C
hanner
;
Peter
C
hiodini
;
Warren
C
. W. Chan
;
John
C
. Bis
c
hof
刊名:Analyti
c
al Chemistry
出版年:2016
3.
The Next Generation of Platinum Drugs: Targeted Pt(II) Agents, Nanoparti
c
le Delivery, and Pt(IV) Prodrugs
作者:
Timothy
C
.
John
stone
;
Kogularamanan Suntharalingam
;
Stephen J. Lippard
刊名:
C
hemi
c
al Reviews
出版年:2016
4.
Fragment-Based Drug Dis
c
overy Targeting Inhibitor of Apoptosis Proteins: Dis
c
overy of a Non-Alanine Lead Series with Dual A
c
tivity Against
c
IAP1 and XIAP
作者:
Gianni
C
hessari
;
Ildiko M. Bu
c
k
;
James E. H. Day
;
Philip J. Day
;
Aman Iqbal
;
C
hristopher N.
John
son
;
Edward J. Lewis
;
Vanessa Martins
;
Dar
c
ey Miller
;
Mi
c
hael
Reader
;
David
C
. Rees
;
Sharna J. Ri
c
h
;
Emiliano Tamanini
;
Mar
c
Vitorino
;
George A. Ward
;
Pamela A. Williams
;
Glyn Williams
;
Ni
c
ola E. Wilsher
;
Alison J.-A. Woolford
刊名:Journal of Medi
c
inal Chemistry
出版年:2015
5.
A Sensitive and Robust Enzyme Kineti
c
Experiment Using Mi
c
roplates and Fluorogeni
c
Ester Substrates
作者:
R. Jeremy
John
son
;
Geoffrey
C
. Hoops
;
C
hristopher J. Savas
;
Za
c
hary Kartje
;
Luke D. Lavis
刊名:Journal of
C
hemi
c
al Edu
c
ation
出版年:2015
6.
Ben
c
hmarking Compound Methods (CBS-QB3, CBS-APNO, G3, G4, W1BD) against the A
c
tive Thermo
c
hemi
c
al Tables: Formation Enthalpies of Radi
c
als
作者:
Kieran P. Somers
;
John
M. Simmie
刊名:Journal of Physi
c
al Chemistry A
出版年:2015
7.
Printed Paper Sensors for Serum La
c
tate Dehydrogenase using Pullulan-Based Inks to Immobilize Reagents
作者:
Balamurali Kannan
;
Sana Jahanshahi-Anbuhi
;
Robert H. Pelton
;
Yingfu Li
;
C
arlos D. M Filipe
;
John
D. Brennan
刊名:Analyti
c
al Chemistry
出版年:2015
8.
Part 2: Designation and Justifi
c
ation of API Starting Materials: Current Pra
c
ti
c
es a
c
ross Member Companies of the IQ Consortium
作者:
Margaret M. Faul
;
C
arl A. Busa
cc
a
;
Magnus
C
. Eriksson
;
Fred Hi
c
ks
;
William F. Kiesman
;
Ma
c
iej Smulkowski
;
John
D. Orr
;
Steven Pfeiffer
刊名:Organi
c
Pro
c
ess Resear
c
h & Development
出版年:2014
9.
Aiming for Ben
c
hmark A
cc
ura
c
y with the Many-Body Expansion
作者:
Ryan M. Ri
c
hard
;
Ka Un Lao
;
John
M. Herbert
刊名:A
cc
ounts of Chemi
c
al Resear
c
h
出版年:2014
10.
Dis
c
overy of 3-Alkoxyamino-5-(pyridin-2-ylamino)pyrazine-2-
c
arbonitriles as Sele
c
tive, Orally Bioavailable CHK1 Inhibitors
作者:
Mi
c
hael Lain
c
hbury
;
Thomas P. Matthews
;
Tatiana M
c
Hardy
;
Kathy J. Boxall
;
Mi
c
hael I. Walton
;
Paul D. Eve
;
Angela Hayes
;
Melanie R. Valenti
;
Alexis K. de Haven Brandon
;
Gary Box
;
G. Wynne Aherne
;
John
C
.
Reader
;
Floren
c
e I. Raynaud
;
Suzanne A. E
cc
les
;
Mi
c
helle D. Garrett
;
Ian
C
ollins
刊名:Journal of Medi
c
inal Chemistry
出版年:2012
1
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