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ACS电子期刊(21)

在“ACS电子期刊”中，命中：21条，耗时：小于0.01 秒

在所有数据库中总计命中：26条

1.Central Nervous System Multiparameter Optimization Desirability: Application in Drug Discovery

作者：Travis T. Wager ; Xinjun Hou ; Patrick R. Verhoest ; Anabella Villalobos

刊名：ACS Chemical Neuroscience

出版年：2016

2.Quantitative Assessment of the Impact of Fluorine Substitution on P-Glycoprotein (P-gp) Mediated Efflux, Permeability, Lipophilicity, and Metabolic Stability

作者：Martin Pettersson ; Xinjun Hou ; Max Kuhn ; Travis T. Wager ; Gregory W. Kauffman ; Patrick R. Verhoest

刊名：Journal of Medicinal Chemistry

出版年：2016

3.Design of Pyridopyrazine-1,6-dione 纬-Secretase Modulators that Align Potency, MDR Efflux Ratio, and Metabolic Stability

作者：Martin Pettersson ; Douglas S. Johnson ; John M. Humphrey ; Todd W. Butler ; Christopher W. am Ende ; Benjamin A. Fish ; Michael E. Green ; Gregory W. Kauffman ; Patrick B. Mullins ; Christopher J. O鈥橠onnell ; Antonia F. Stepan ; Cory M. Stiff ; Chakrapani Subramanyam ; Tuan P. Tran ; Beth Cooper Vetelino ; Eddie Yang ; Longfei Xie ; Kelly R. Bales ; Leslie R. Pustilnik ; Stefanus J. Steyn ; Kathleen M. Wood ; Patrick R. Verhoest

刊名：ACS Medicinal Chemistry Letters

出版年：2015

4.Challenges and Opportunities in the Discovery of New Therapeutics Targeting the Kynurenine Pathway

作者：Amy B. Dounay ; Jamison B. Tuttle ; Patrick R. Verhoest

刊名：Journal of Medicinal Chemistry

出版年：2015

5.Discovery and Preclinical Profiling of 3-[4-(Morpholin-4-yl)-7H-pyrrolo[2,3-d]pyrimidin-5-yl]benzonitrile (PF-06447475), a Highly Potent, Selective, Brain Penetrant, and in Vivo Active L

作者：Jaclyn L. Henderson ; Bethany L. Kormos ; Matthew M. Hayward ; Karen J. Coffman ; Jayasankar Jasti ; Ravi G. Kurumbail ; Travis T. Wager ; Patrick R. Verhoest ; G. Stephen Noell ; Yi Chen ; Elie Needle ; Zdenek Berger ; Stefanus J. Steyn ; Christopher Houle ; Warren D. Hirst ; Paul Galatsis

刊名：Journal of Medicinal Chemistry

出版年：2015

6.Design, Synthesis, and Pharmacological Evaluation of a Novel Series of Pyridopyrazine-1,6-dione γ-Secretase Modulators

作者：Martin Pettersson ; Douglas S. Johnson ; Chakrapani Subramanyam ; Kelly R. Bales ; Christopher W. am Ende ; Benjamin A. Fish ; Michael E. Green ; Gregory W. Kauffman ; Patrick B. Mullins ; Thayalan Navaratnam ; Subas M. Sakya ; Cory M. Stiff ; Tuan P. Tran ; Longfei Xie ; Liming Zhang ; Leslie R. Pustilnik ; Beth C. Vetelino ; Kathleen M. Wood ; Nikolay Pozdnyakov ; Patrick R. Verhoest ; Christopher J. O’Donnell

刊名：Journal of Medicinal Chemistry

出版年：2014

7.Discovery and Preclinical Characterization of 1-Methyl-3-(4-methylpyridin-3-yl)-6-(pyridin-2-ylmethoxy)-1H-pyrazolo-[3,4-b]pyrazine (PF470): A Highly Potent, Selective, and Efficacious M

作者：Lei Zhang ; Gayatri Balan ; Gabriela Barreiro ; Brian P. Boscoe ; Lois K. Chenard ; Julie Cianfrogna ; Michelle M. Claffey ; Laigao Chen ; Karen J. Coffman ; Susan E. Drozda ; Joshua R. Dunetz ; Kari R. Fonseca ; Paul Galatsis ; Sarah Grimwood ; John T. Lazzaro ; Jessica Y. Mancuso ; Emily L. Miller ; Matthew R. Reese ; Bruce N. Rogers ; Isao Sakurada ; Marc Skaddan ; Deborah L. Smith ; Antonia F. Stepan ; Patrick Trapa ; Jamison B. Tuttle ; Patrick R. Verhoest ; Daniel P. Walker ; Ann S. Wright ; Margaret M. Zaleska ; Kenneth Zasadny ; Christopher L. Shaffer

刊名：Journal of Medicinal Chemistry

出版年：2014

8.1-(2-Hydroxy-2-methyl-3-phenoxypropanoyl)indoline-4-carbonitrile Derivatives as Potent and Tissue Selective Androgen Receptor Modulators

作者：Eugene L. Piatnitski Chekler ; Rayomond Unwalla ; Taukeer A. Khan ; Raghuram S. Tangirala ; Mark Johnson ; Michael St. Andre ; James T. Anderson ; Thomas Kenney ; Sue Chiparri ; Chris McNally ; Edward Kilbourne ; Catherine Thompson ; Sunil Nagpal ; Gregory Weber ; Scott Schelling ; Jane Owens ; Carl A. Morris ; Dennis Powell ; Patrick R. Verhoest ; Adam M. Gilbert

刊名：Journal of Medicinal Chemistry

出版年：2014

9.Chemoproteomics Demonstrates Target Engagement and Exquisite Selectivity of the Clinical Phosphodiesterase 10A Inhibitor MP-10 in Its Native Environment

作者：Jan-Philip Sch眉lke ; Laura A. McAllister ; Kieran F. Geoghegan ; Vinod Parikh ; Thomas A. Chappie ; Patrick R. Verhoest ; Christopher J. Schmidt ; Douglas S. Johnson ; Nicholas J. Brandon

刊名：ACS Chemical Biology

出版年：2014

10.Structure-Based Design of Irreversible Human KAT II Inhibitors: Discovery of New Potency-Enhancing Interactions

作者：Jamison B. Tuttle ; Marie Anderson ; Bruce M. Bechle ; Brian M. Campbell ; Cheng Chang ; Amy B. Dounay ; Edelweiss Evrard ; Kari R. Fonseca ; Xinmin Gan ; Somraj Ghosh ; Weldon Horner ; Larry C. James ; Ji-Young Kim ; Laura A. McAllister ; Jayvardhan Pandit ; Vinod D. Parikh ; Brian J. Rago ; Michelle A. Salafia ; Christine A. Strick ; Laura E. Zawadzke ; Patrick R. Verhoest

刊名：ACS Medicinal Chemistry Letters

出版年：2013

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