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CNKI学位论文(63)
知网期刊论文(6)
在“
ACS电子期刊
”中,
命中:
10
条,耗时:0.0219895 秒
在所有数据库中总计命中:
69
条
1.
Aminomethyl-Derived Beta Secretase (BACE1) Inhibitors: Engaging Gly230 without an Anilide Functionality
作者:
Christopher
R. ButlerKevin Ogilvie
;
Luis Martinez-Alsina
;
Gabriela Barreiro
;
Elizabeth M. Beck
;
Charles E. Nolan
;
Kevin Atchison
;
Eric Benvenuti
;
Leanne Buzon
;
Shawn Doran
;
Cathleen Gonzales
;
Christopher
J
.
Helal
;
Xin
j
un Hou
;
Mei-Hui Hsu
;
Eric F.
J
ohnson
;
Kimberly Lapham
;
Lorraine Lanyon
;
Kevin Parris
;
Brian T. O’Neill
;
David Riddell
;
Ashley Robshaw
;
Felix Va
j
dos
;
Michael A. Brodney
刊名:
J
ournal of Medicinal Chemistry
出版年:2017
2.
Discovery of the Potent and Selective M1 PAM-Agonist N-[(3R,4S)-3-Hydroxytetrahydro-2H-pyran-4-yl]-5-methyl-4-[4-(1,3-thiazol-4-yl)benzyl]pyridine-2-carboxamide (PF-06767832): Evaluation of Efficacy and Cholinergic Side Effects
作者:
J
ennifer E. Davoren
;
Che-Wah Lee
;
Michelle Garnsey
;
Michael A. Brodney
;
J
ason Cordes
;
Keith Dlugolenski
;
J
eremy R. Edgerton
;
Anthony R. Harris
;
Christopher
J
.
Helal
;
Stephen
J
enkinson
;
Gregory W. Kauffman
;
Terrence P. Kenakin
;
J
ohn T. Lazzaro
;
Susan M. Lotarski
;
Yuxia Mao
;
Deane M. Nason
;
Carrie Northcott
;
Lisa Nottebaum
;
Steven V. O’Neil
;
Betty Pettersen
;
Michael Popiolek
;
Veronica Reinhart
;
Romelia Salomon-Ferrer
;
Stefanus
J
. Steyn
;
Damien Webb
;
Lei Zhang
;
Sarah Grimwood
刊名:
J
ournal of Medicinal Chemistry
出版年:2016
3.
Discovery of a Series of Efficient, Centrally Efficacious BACE1 Inhibitors through Structure-Based Drug Design
作者:
Christopher
R. Butler
;
Michael A. Brodney
;
Elizabeth M. Beck
;
Gabriela Barreiro
;
Charles E. Nolan
;
Feng Pan
;
Felix Va
j
dos
;
Kevin Parris
;
Alison H. Varghese
;
Christopher
J
.
Helal
;
Ricardo Lira
;
Shawn D. Doran
;
David R. Riddell
;
Leanne M. Buzon
;
J
ason K. Dutra
;
Luis A. Martinez-Alsina
;
Kevin Ogilvie
;
J
ohn C. Murray
;
J
oseph M. Young
;
Kevin Atchison
;
Ashley Robshaw
;
Cathleen Gonzales
;
J
inlong Wang
;
Yong Zhang
;
Brian T. O鈥橬eill
刊名:
J
ournal of Medicinal Chemistry
出版年:2015
4.
Design and Selection Parameters to Accelerate the Discovery of Novel Central Nervous System Positron Emission Tomography (PET) Ligands and Their Application in the Development of a Novel Phosphodieste
作者:
Lei Zhang
;
Anabella Villalobos
;
Elizabeth M. Beck
;
Thomas Bocan
;
Thomas A. Chappie
;
Laigao Chen
;
Sarah Grimwood
;
Steven D. Heck
;
Christopher
J
.
Helal
;
Xin
j
un Hou
;
J
ohn M. Humphrey
;
J
iemin Lu
;
Marc B. Skaddan
;
Timothy
J
. McCarthy
;
Patrick R. Verhoest
;
Travis T. Wager
;
Kenneth Zasadny
刊名:
J
ournal of Medicinal Chemistry
出版年:2013
5.
Design and Discovery of 6-[(3S,4S)-4-Methyl-1-(pyrimidin-2-ylmethyl)pyrrolidin-3-yl]-1-(tetrahydro-2H-pyran-4-yl)-1,5-dihydro-4H-pyrazolo[3,4-d]pyrimidin-4-one (PF-0
作者:
Patrick R. Verhoest
;
Kari R. Fonseca
;
Xin
j
un Hou
;
Caroline Proulx-LaFrance
;
Michael Corman
;
Christopher
J
.
Helal
;
Michelle M. Claffey
;
J
amison B. Tuttle
;
Karen
J
. Coffman
;
Shenpinq Liu
;
Frederick Nelson
;
Robin
J
. Kleiman
;
Frank S. Menniti
;
Christopher
J
. Schmidt
;
Michelle Vanase-Frawley
;
Spiros Liras
刊名:
J
ournal of Medicinal Chemistry
出版年:2012
6.
Application of Structure-Based Drug Design and Parallel Chemistry to Identify Selective, Brain Penetrant, In Vivo Active Phosphodiesterase 9A Inhibitors
作者:
Michelle M. Claffey
;
Christopher
J
.
Helal
;
Patrick R. Verhoest
;
Zhi
j
un Kang
;
Kristina S. Fors
;
Stanley
J
ung
;
J
iaying Zhong
;
Mark W. Bundesmann
;
Xin
j
un Hou
;
Shenping Lui
;
Robin
J
. Kleiman
;
Michelle Vanase-Frawley
;
Anne W. Schmidt
;
Frank Menniti
;
Christopher
J
. Schmidt
;
William E. Hoffman
;
Mihaly Ha
j
os
;
Laura McDowell
;
Rebecca E. O鈥機onnor
;
Mary MacDougall-Murphy
;
Kari R. Fonseca
;
Stacey L. Becker
;
Frederick R. Nelson
;
Spiros Liras
刊名:
J
ournal of Medicinal Chemistry
出版年:2012
7.
Current Landscape of Phosphodiesterase 10A (PDE10A) Inhibition
作者:
Thomas A. Chappie
;
Christopher
J
.
Helal
;
Xin
j
un Hou
刊名:
J
ournal of Medicinal Chemistry
出版年:2012
8.
Use of Structure-Based Design to Discover a Potent, Selective, In Vivo Active Phosphodiesterase 10A Inhibitor Lead Series for the Treatment of Schizophrenia
作者:
Christopher
J
.
Helal
;
Zhi
j
un Kang
;
Xin
j
un Hou
;
J
ayvardhan Pandit
;
Thomas A. Chappie
;
J
ohn M. Humphrey
;
Eric S. Marr
;
Kimberly F. Fennell
;
Lois K. Chenard
;
Carol Fox
;
Christopher
J
. Schmidt
;
Robert D. Williams
;
Douglas S. Chapin
;
J
udith Siuciak
;
Lorraine Lebel
;
Frank Menniti
;
J
ulia Cianfrogna
;
Kari R. Fonseca
;
Frederick R. Nelson
;
Rebecca O鈥機onnor
;
Mary MacDougall
;
Laura McDowell
;
Spiros Liras
刊名:
J
ournal of Medicinal Chemistry
出版年:2011
9.
Identification of a Brain Penetrant PDE9A Inhibitor Utilizing Prospective Design and Chemical Enablement as a Rapid Lead Optimization Strategy
作者:
Patrick R. Verhoest
;
Caroline Proulx-Lafrance
;
Michael Corman
;
Lois Chenard
;
Christopher
J
.
Helal
;
Xin
j
un Hou
;
Robin Kleiman
;
Shenping Liu
;
Eric Marr
;
Frank S. Menniti
;
Christopher
J
. Schmidt
;
Michell
刊名:
J
ournal of Medicinal Chemistry
出版年:2009
10.
Direct Catalytic Enantioselective Reduction of Achiral ,
作者:
Christopher
J
.
Helal
;
Plato A. Magriotis
;
and E.
J
. Corey
刊名:
J
ournal of the American Chemical Society
出版年:1996
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