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Springer电子图书(1)
CNKI学位论文(17)
知网期刊论文(3)
在“
ACS电子期刊
”中,
命中:
9
条,耗时:小于0.01 秒
在所有数据库中总计命中:
21
条
1.
Aminomethyl-Derived Beta Secretase (BACE1) Inhibitors: Engaging Gly230 without an Anilide Functionality
作者:
Christopher R. ButlerKevin Ogilvie
;
Luis Martinez-Alsina
;
Gabriela Barreiro
;
Elizabeth M. Beck
;
Charles E. Nolan
;
Kevin Atchison
;
Eric Benvenuti
;
Leanne Buzon
;
Shawn Doran
;
Cathleen Gonzales
;
Christopher J. Helal
;
Xinjun Hou
;
Mei-Hui Hsu
;
Eric F. Johnson
;
Kimberly Lapham
;
Lorraine Lanyon
;
Kevin Parris
;
Brian T. O’Neill
;
David Riddell
;
Ashley Robshaw
;
Felix Vajdos
;
Michael
A.
Brodney
刊名:Journal of Medicinal Chemistry
出版年:2017
2.
Discovery of the Potent and Selective M1 PAM-Agonist N-[(3R,4S)-3-Hydroxytetrahydro-2H-pyran-4-yl]-5-methyl-4-[4-(1,3-thiazol-4-yl)benzyl]pyridine-2-carboxamide (PF-06767832): Evaluation of Efficacy and Cholinergic Side Effects
作者:
Jennifer E. Davoren
;
Che-Wah Lee
;
Michelle Garnsey
;
Michael
A.
Brodney
;
Jason Cordes
;
Keith Dlugolenski
;
Jeremy R. Edgerton
;
Anthony R. Harris
;
Christopher J. Helal
;
Stephen Jenkinson
;
Gregory W. Kauffman
;
Terrence P. Kenakin
;
John T. Lazzaro
;
Susan M. Lotarski
;
Yuxia Mao
;
Deane M. Nason
;
Carrie Northcott
;
Lisa Nottebaum
;
Steven V. O’Neil
;
Betty Pettersen
;
Michael
Popiolek
;
Veronica Reinhart
;
Romelia Salomon-Ferrer
;
Stefanus J. Steyn
;
Damien Webb
;
Lei Zhang
;
Sarah Grimwood
刊名:Journal of Medicinal Chemistry
出版年:2016
3.
Two Routes to 4-Fluorobenzisoxazol-3-one in the Synthesis of a 5-HT4 Partial Agonist
作者:
Daniel W. Widlicka
;
John C. Murray
;
Karen J. Coffman
;
Chunguang Xiao
;
Michael
A.
Brodney
;
Joseph P. Rainville
;
Brian Samas
刊名:Organic Process Research & Development
出版年:2016
4.
Discovery of a Series of Efficient, Centrally Efficacious BACE1 Inhibitors through Structure-Based Drug Design
作者:
Christopher R. Butler
;
Michael
A.
Brodney
;
Elizabeth M. Beck
;
Gabriela Barreiro
;
Charles E. Nolan
;
Feng Pan
;
Felix Vajdos
;
Kevin Parris
;
Alison H. Varghese
;
Christopher J. Helal
;
Ricardo Lira
;
Shawn D. Doran
;
David R. Riddell
;
Leanne M. Buzon
;
Jason K. Dutra
;
Luis A. Martinez-Alsina
;
Kevin Ogilvie
;
John C. Murray
;
Joseph M. Young
;
Kevin Atchison
;
Ashley Robshaw
;
Cathleen Gonzales
;
Jinlong Wang
;
Yong Zhang
;
Brian T. O鈥橬eill
刊名:Journal of Medicinal Chemistry
出版年:2015
5.
Utilizing Structures of CYP2D6 and BACE1 Complexes To Reduce Risk of Drug鈥揇rug Interactions with a Novel Series of Centrally Efficacious BACE1 Inhibitors
作者:
Michael
A.
Brodney
;
Elizabeth M. Beck
;
Christopher R. Butler
;
Gabriela Barreiro
;
Eric F. Johnson
;
David Riddell
;
Kevin Parris
;
Charles E. Nolan
;
Ying Fan
;
Kevin Atchison
;
Cathleen Gonzales
;
Ashley E. Robshaw
;
Shawn D. Doran
;
Mark W. Bundesmann
;
Leanne Buzon
;
Jason Dutra
;
Kevin Henegar
;
Erik LaChapelle
;
Xinjun Hou
;
Bruce N. Rogers
;
Jayvardhan Pandit
;
Ricardo Lira
;
Luis Martinez-Alsina
;
Peter Mikochik
;
John C. Murray
;
Kevin Ogilvie
;
Loren Price
;
Subas M. Sakya
;
Aijia Yu
;
Yong Zhang
;
Brian T. O鈥橬eill
刊名:Journal of Medicinal Chemistry
出版年:2015
6.
Stereoselective Synthesis of Spiropiperidines as BACE-1 Aspartyl Protease Inhibitors via Late Stage N-Arylation of a 1,8-Diazaspiro[4.5]dec-3-en-2-one Pharmacophore
作者:
Che-Wah Lee
;
Ricardo Lira
;
Jason Dutra
;
Kevin Ogilvie
;
Brian T. O鈥橬eill
;
Michael
Brodney
;
Christopher Helal
;
Joseph Young
;
Erik Lachapelle
;
Subas Sakya
;
John C. Murray
刊名:The Journal of Organic Chemistry
出版年:2013
7.
Spirocyclic Sulfamides as 尾-Secretase 1 (BACE-1) Inhibitors for the Treatment of Alzheimer鈥檚 Disease: Utilization of Structure Based Drug Design, WaterMap, and CNS Penetration Studies To Identify Cent
作者:
Michael
A.
Brodney
;
Gabriela Barreiro
;
Kevin Ogilvie
;
Eva Hajos-Korcsok
;
John Murray
;
Felix Vajdos
;
Claude Ambroise
;
Curt Christoffersen
;
Katherine Fisher
;
Lorraine Lanyon
;
JianHua Liu
;
Charles E. Nolan
;
Jane M. Withka
;
Kris A. Borzilleri
;
Ivan Efremov
;
Christine E. Oborski
;
Alison Varghese
;
Brian T. O鈥橬eill
刊名:Journal of Medicinal Chemistry
出版年:2012
8.
Identification of Multiple 5-HT4 Partial Agonist Clinical Candidates for the Treatment of Alzheimer鈥檚 Disease
作者:
Michael
A.
Brodney
;
David E. Johnson
;
Aarti Sawant-Basak
;
Karen J. Coffman
;
Elena M. Drummond
;
Emily L. Hudson
;
Katherine E. Fisher
;
Hirohide Noguchi
;
Nobuaki Waizumi
;
Laura L. McDowell
;
Alexandros Papanikolaou
;
Betty A. Pettersen
;
Anne W. Schmidt
;
Elaine Tseng
;
Kim Stutzman-Engwall
;
David M. Rubitski
;
Michelle A. Vanase-Frawley
;
Sarah Grimwood
刊名:Journal of Medicinal Chemistry
出版年:2012
9.
1-[(1-Methyl-1H-imidazol-2-yl)methyl]-4-phenylpiperidines as mGluR2 Positive Allosteric Modulators for the Treatment of Psychosis
作者:
Lei Zhang
;
Michael
A.
Brodney
;
John Candler
;
Angela C. Doran
;
Allen J. Duplantier
;
Ivan V. Efremov
;
Edel Evrard
;
Kenneth Kraus
;
Alan H. Ganong
;
Jessica A. Haas
;
Ashley N. Hanks
;
Keith Jenza
;
John T. Lazzaro
;
Noha Maklad
;
Sheryl A. McCarthy
;
Weimin Qian
;
Bruce N. Rogers
;
Melinda D. Rottas
;
Christopher J. Schmidt
;
Judith A. Siuciak
;
F. David Tingley
;
III
;
Andy Q. Zhang
刊名:Journal of Medicinal Chemistry
出版年:2011
1
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