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在“ACS电子期刊”中，命中：8条，耗时：小于0.01 秒

在所有数据库中总计命中：30条

1.Multiparameter Lead Optimization to Give an Oral Checkpoint Kinase 1 (CHK1) Inhibitor Clinical Candidate: (R)-5-((4-((Morpholin-2-ylmethyl)amino)-5-(trifluoromethyl)pyridin-2-yl)amino)pyrazine-2-carbonitrile (CCT245737)

作者：James D. Osborne ; Thomas P. Matthews ; Tatiana McHardy ; Nicolas Proisy ; Kwai-Ming J. Cheung ; Michael Lainchbury ; Nathan Brown ; Michael I. Walton ; Paul D. Eve ; Katherine J. Boxall ; Angela Hayes ; Alan T. Henley ; Melanie R. Valenti ; Alexis K. De Haven Brandon ; Gary Box ; Yann Jamin ; Simon P. Robinson ; Isaac M. Westwood ; Rob L. M. van Montfort ; Philip M. Leonard ; Marieke B. A. C. Lamers ; John C. Reader ; G. Wynne Aherne ; Florence I. Raynaud ; Suzanne A. Eccles ; Michelle D. Garrett ; Ian Collins

刊名：Journal of Medicinal Chemistry

出版年：2016

2.Pyridones as Highly Selective, Noncovalent Inhibitors of T790M Double Mutants of EGFR

作者：Marian C. Bryan ; Daniel J. Burdick ; Bryan K. Chan ; Yuan Chen ; Saundra Clausen ; Jennafer Dotson ; Charles Eigenbrot ; Richard Elliott ; Emily J. Hanan ; Robert Heald ; Philip Jackson ; Hank La ; Michael Lainchbury ; Shiva Malek ; Sam E. Mann ; Hans E. Purkey ; Gabriele Schaefer ; Stephen Schmidt ; Eileen Seward ; Steve Sideris ; Shumei Wang ; Ivana Yen ; Christine Yu ; Timothy P. Heffron

刊名：ACS Medicinal Chemistry Letters

出版年：2016

3.Correction to Noncovalent Mutant Selective Epidermal Growth Factor Receptor Inhibitors: A Lead Optimization Case Study

作者：Robert Heald ; Krista K. Bowman ; Marian C. Bryan ; Daniel Burdick ; Bryan Chan ; Emily Chan ; Yuan Chen ; Saundra Clausen ; Belen Dominguez-Fernandez ; Charles Eigenbrot ; Richard Elliott ; Emily J. Hanan ; Philip Jackson ; Jamie Knight ; Hank La ; Michael Lainchbury ; Shiva Malek ; Sam Mann ; Mark Merchant ; Kyle Mortara ; Hans Purkey ; Gabriele Schaefer ; Stephen Schmidt ; Eileen Seward ; Steve Sideris ; Lily Shao ; Shumei Wang ; Kuen Yeap ; Ivana Yen ; Christine Yu ; Timothy P. Heffron

刊名：Journal of Medicinal Chemistry

出版年：2016

4.Discovery of a Noncovalent, Mutant-Selective Epidermal Growth Factor Receptor Inhibitor

作者：Bryan K. Chan ; Emily J. Hanan ; Krista K. Bowman ; Marian C. Bryan ; Daniel Burdick ; Emily Chan ; Yuan Chen ; Saundra Clausen ; Trisha Dela Vega ; Jennafer Dotson ; Charles Eigenbrot ; Richard L. Elliott ; Robert A. Heald ; Philip S. Jackson ; Jamie D. Knight ; Hank La ; Michael D. Lainchbury ; Shiva Malek ; Hans E. Purkey ; Gabriele Schaefer ; Stephen Schmidt ; Eileen M. Seward ; Steve Sideris ; Lily Shao ; Shumei Wang ; Siew Kuen Yeap ; Ivana Yen ; Christine Yu ; Timothy P. Heffron

刊名：Journal of Medicinal Chemistry

出版年：2016

5.Noncovalent Mutant Selective Epidermal Growth Factor Receptor Inhibitors: A Lead Optimization Case Study

刊名：Journal of Medicinal Chemistry

出版年：2015

6.Discovery of Selective and Noncovalent Diaminopyrimidine-Based Inhibitors of Epidermal Growth Factor Receptor Containing the T790M Resistance Mutation

作者：Emily J. Hanan ; Charles Eigenbrot ; Marian C. Bryan ; Daniel J. Burdick ; Bryan K. Chan ; Yuan Chen ; Jennafer Dotson ; Robert A. Heald ; Philip S. Jackson ; Hank La ; Michael D. Lainchbury ; Shiva Malek ; Hans E. Purkey ; Gabriele Schaefer ; Stephen Schmidt ; Eileen M. Seward ; Steve Sideris ; Christine Tam ; Shumei Wang ; Siew Kuen Yeap ; Ivana Yen ; Jianping Yin ; Christine Yu ; Inna Zilberleyb ; Timothy P. Heffron

刊名：Journal of Medicinal Chemistry

出版年：2014

7.Discovery of 3-Alkoxyamino-5-(pyridin-2-ylamino)pyrazine-2-carbonitriles as Selective, Orally Bioavailable CHK1 Inhibitors

作者：Michael Lainchbury ; Thomas P. Matthews ; Tatiana McHardy ; Kathy J. Boxall ; Michael I. Walton ; Paul D. Eve ; Angela Hayes ; Melanie R. Valenti ; Alexis K. de Haven Brandon ; Gary Box ; G. Wynne Aherne ; John C. Reader ; Florence I. Raynaud ; Suzanne A. Eccles ; Michelle D. Garrett ; Ian Collins

刊名：Journal of Medicinal Chemistry

出版年：2012

8.A Protecting Group Free Synthesis of (±)-Neostenine via the [5 + 2] Photocycloaddition of Maleimides

作者：Michael D. Lainchbury ; Marcus I. Medley ; Piers M. Taylor ; Paul Hirst ; Wolfgang Dohle ; Kevin I. Booker-Milburn

刊名：Journal of Organic Chemistry

出版年：2008

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