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在“ACS电子期刊”中，命中：9条，耗时：小于0.01 秒

1.Oxopyrido[2,3-d]pyrimidines as Covalent L858R/T790M Mutant Selective Epidermal Growth Factor Receptor (EGFR) Inhibitors

作者：Ryan P. Wurz ; Liping H. Pettus ; Kate Ashton ; James Brown ; Jian Jeffrey Chen ; Brad Herberich ; Fang-Tsao Hong ; Essa Hu-Harrington ; Tom Nguyen ; David J. St. Jean ; Jr. ; Seifu Tadesse ; David Bauer ; Michele Kubryk ; Jinghui Zhan ; Keegan Cooke ; Petia Mitchell ; Kristin L. Andrews ; Faye Hsieh ; Dean Hickman ; Nataraj Kalyanaraman ; Tian Wu ; Darren L. Reid ; Edward K. Lobenhofer ; Dina A. Andrews ; Nancy Everds ; Roberto Guzman ; Andrew T. Parsons ; Simon J. Hedley ; Jason Tedrow ; Oliver R. Thiel ; Matthew Potter ; Robert Radinsky ; Pedro J. Beltran ; Andrew S. Tasker

刊名：ACS Medicinal Chemistry Letters

出版年：2015

2.Small Molecule Disruptors of the Glucokinase鈥揋lucokinase Regulatory Protein Interaction: 5. A Novel Aryl Sulfone Series, Optimization Through Conformational Analysis

作者：Nuria A. Tamayo ; Mark H. Norman ; Michael D. Bartberger ; Fang-Tsao Hong ; Yunxin Bo ; Longbin Liu ; Nobuko Nishimura ; Kevin C. Yang ; Seifu Tadesse ; Christopher Fotsch ; Jie Chen ; Samer Chmait ; Rod Cupples ; Clarence Hale ; Steven R. Jordan ; David J. Lloyd ; Glenn Sivits ; Gwyneth Van ; David J. St. Jean ; Jr.

刊名：Journal of Medicinal Chemistry

出版年：2015

3.Discovery and Structure-Guided Optimization of Diarylmethanesulfonamide Disrupters of Glucokinase–Glucokinase Regulatory Protein (GK–GKRP) Binding: Strategic Use of a N → S (nN → σ*S–X) Interaction fo

作者：Lewis D. Pennington ; Michael D. Bartberger ; Michael D. Croghan ; Kristin L. Andrews ; Kate S. Ashton ; Matthew P. Bourbeau ; Jie Chen ; Samer Chmait ; Rod Cupples ; Christopher Fotsch ; Joan Helmering ; Fang-Tsao Hong ; Randall W. Hungate ; Steven R. Jordan ; Ke Kong ; Longbin Liu ; Klaus Michelsen ; Carolyn Moyer ; Nobuko Nishimura ; Mark H. Norman ; Andreas Reichelt ; Aaron C. Siegmund ; Glenn Sivits ; Seifu Tadesse ; Christopher M. Tegley ; Gwyneth Van ; Kevin C. Yang ; Guomin Yao ; Jiandong Zhang ; David J. Lloyd ; Clarence Hale ; David J. St. Jean Jr.

刊名：Journal of Medicinal Chemistry

出版年：2015

4.Small Molecule Disruptors of the Glucokinase鈥揋lucokinase Regulatory Protein Interaction: 4. Exploration of a Novel Binding Pocket

作者：Fang-Tsao Hong ; Mark H. Norman ; Kate S. Ashton ; Michael D. Bartberger ; Jie Chen ; Samer Chmait ; Rod Cupples ; Christopher Fotsch ; Steven R. Jordan ; David J. Lloyd ; Glenn Sivits ; Seifu Tadesse ; Clarence Hale ; David J. St. Jean ; Jr.

刊名：Journal of Medicinal Chemistry

出版年：2014

5.Small Molecule Disruptors of the Glucokinase–Glucokinase Regulatory Protein Interaction: 2. Leveraging Structure-Based Drug Design to Identify Analogues with Improved Pharmacokinetic Profiles

作者：David J. St. Jean ; Jr. ; Kate S. Ashton ; Michael D. Bartberger ; Jie Chen ; Samer Chmait ; Rod Cupples ; Elizabeth Galbreath ; Joan Helmering ; Fang-Tsao Hong ; Steven R. Jordan ; Longbin Liu ; Roxanne K. Kunz ; Klaus Michelsen ; Nobuko Nishimura ; Lewis D. Pennington ; Steve F. Poon ; Darren Reid ; Glenn Sivits ; Markian M. Stec ; Seifu Tadesse ; Nuria Tamayo ; Gwyneth Van ; Kevin C. Yang ; Jiandong Zhang ; Mark H. Norman ; Christopher Fotsch ; David J. Lloyd ; Clarence Hale

刊名：Journal of Medicinal Chemistry

出版年：2014

6.Structure-Based Design of a Novel Series of Potent, Selective Inhibitors of the Class I Phosphatidylinositol 3-Kinases

作者：Adrian L. Smith ; Noel D. D鈥橝ngelo ; Yunxin Y. Bo ; Shon K. Booker ; Victor J. Cee ; Brad Herberich ; Fang-Tsao Hong ; Claire L. M. Jackson ; Brian A. Lanman ; Longbin Liu ; Nobuko Nishimura ; Liping H. Pettus ; Anthony B. Reed ; Seifu Tadesse ; Nuria A. Tamayo ; Ryan P. Wurz ; Kevin Yang ; Kristin L. Andrews ; Douglas A. Whittington ; John D. McCarter ; Tisha San Miguel ; Leeanne Zalameda ; Jian Jiang ; Raju Subramanian ; Erin L. Mullady ; Sean Caenepeel ; Daniel J. Freeman ; Ling Wang ; Nancy Zhang ; Tian Wu ; Paul E. Hughes ; Mark H. Norman

刊名：Journal of Medicinal Chemistry

出版年：2012

7.Selective Class I Phosphoinositide 3-Kinase Inhibitors: Optimization of a Series of Pyridyltriazines Leading to the Identification of a Clinical Candidate, AMG 511

作者：Mark H. Norman ; Kristin L. Andrews ; Yunxin Y. Bo ; Shon K. Booker ; Sean Caenepeel ; Victor J. Cee ; Noel D. D鈥橝ngelo ; Daniel J. Freeman ; Bradley J. Herberich ; Fang-Tsao Hong ; Claire L. M. Jackson ; Jian Jiang ; Brian A. Lanman ; Longbin Liu ; John D. McCarter ; Erin L. Mullady ; Nobuko Nishimura ; Liping H. Pettus ; Anthony B. Reed ; Tisha San Miguel ; Adrian L. Smith ; Markian M. Stec ; Seifu Tadesse ; Andrew Tasker ; Divesh Aidasani ; Xiaochun Zhu ; Raju Subramanian ; Nuria A. Tamayo ; Ling Wang ; Douglas A. Whittington ; Bin Wu ; Tian Wu ; Ryan P. Wurz ; Kevin Yang ; Leeanne Zalameda ; Nancy Zhang ; Paul E. Hughes

刊名：Journal of Medicinal Chemistry

出版年：2012

8.Correction to Selective Class I Phosphoinositide 3-Kinase Inhibitors: Optimization of a Series of Pyridyltriazines Leading to the Identification of a Clinical Candidate, AMG 511

刊名：Journal of Medicinal Chemistry

出版年：2012

9.Cytochrome P450-Mediated Epoxidation of 2-Aminothiazole-Based AKT Inhibitors: Identification of Novel GSH Adducts and Reduction of Metabolic Activation through Structural Changes Guided by in Silico a

作者：Raju Subramanian ; Matthew R. Lee ; John G. Allen ; Matthew P. Bourbeau ; Christopher Fotsch ; Fang-Tsao Hong ; Seifu Tadesse ; Guomin Yao ; Chester C. Yuan ; Sekhar Surapaneni ; Gary L. Skiles ; Xianghong Wang

刊名：Chemical Research in Toxicology

出版年：2010

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