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在“
SpringerLink电子期刊
”中,
命中:
15
条,耗时:0.0120268 秒
1.
Activation of IGF-1 and Insulin Signaling Pathways Ameliorate Mitochondrial Function and Energy Metabolism in Huntington’s Disease Human Lymphoblasts
作者:
Luana Naia
;
I. Luísa Ferreira
;
Teresa Cunha-Oliveira…
关键词:
Huntington’s disease
;
Insulin
;
IGF
1 ;
Intracellular signaling
;
Mitochondria
;
Energy metabolism
刊名:Molecular Neurobiology
出版年:2015
2.
Polyglutamine toxicity in yeast induces metabolic alterations and mitochondrial defects
作者:
Katharina Papsdorf
;
Christoph J. O. Kaiser
;
Adrian Drazic…
关键词:
Polyglutamine
;
Iron
;
sulfur cluster
;
Mitochondria
;
Neurodegenerative disease
刊名:BMC Genomics
出版年:2015
3.
Spinocerebellar Ataxia Type 2: Clinical Presentation, Molecular Mechanisms, and Therapeutic Perspectives
作者:
J. J. Maga?a (1)
L. Velázquez-Pérez (2)
B. Cisneros (3)
关键词:
Spinocerebellar ataxia type 2
;
Ataxin
2 ;
Molecular mechanisms
;
Polyglutamines
;
Trinucleotide repeats
;
Gene therapy
刊名:Molecular Neurobiology
出版年:2013
4.
Evidence for dynamic and multiple roles for huntingtin in Ciona intestinalis
作者:
Mohammed M. Idris (1) (2)
Michael C. Thorndyke (3)
Euan R. Brown (2) (4)
关键词:
Ciona intestinalis
;
Mesenchyme cells
;
Stem cells
;
Cell migration
;
Chordate nervous system
;
Evolution
;
Neuropathology
;
Polyglutamines
;
Huntingtons disease
刊名:Invertebrate Neuroscience
出版年:2013
5.
Large-scale functional RNAi screen in C. elegans identifies genes that regulate the dysfunction of mutant polyglutamine neurons
作者:
Fran?ois-Xavier Lejeune (1)
Lilia Mesrob (1)
Frédéric Parmentier (1)
Cedric Bicep (1) (2)
Rafael P Vazquez-Manrique (1) (2)
J Alex Parker (1) (2) (3)
Jean-Philippe Vert (4) (5) (6)
Cendrine Tourette (1) (2) (7)
Christian Neri (1) (2)
刊名:BMC Genomics
出版年:2012
6.
Glial S100B Protein Modulates Mutant Ataxin-1 Aggregation and Toxicity: TRTK12 Peptide, a Potential Candidate for SCA1 Therapy
作者:
Parminder J. S. Vig (1) (2)
Scoty Hearst (1) (2)
Qingmei Shao (1)
Mariper E. Lopez (1)
Henry A. Murphy II (1)
Eshan Safaya (1)
关键词:
Purkinje cells
;
S100B
;
Ataxin
1 ;
Spinocerebellar ataxia
1 ;
Cerebellum
;
Vacuoles
;
Neurodegeneration
;
Bergmann glia
刊名:The Cerebellum
出版年:2011
7.
Identification of the porcine homologous of human disease causing trinucleotide repeat sequences
作者:
Lone Bruhn Madsen
;
Bo Thomsen
;
Christina Ane Elisabeth S?lvsten
;
Christian Bendixen
;
Merete Fredholm
;
Arne Lund J?rgensen and Anders Lade Nielsen
关键词:
Neurodegeneration
;
Repeat expansion
;
Ataxia
;
Animal models
;
Genomics
刊名:neurogenetics
出版年:2007
8.
Identification of the porcine homologous of human disease causing trinucleotide repeat sequences
作者:
Lone Bruhn Madsen
;
Bo Thomsen
;
Christina Ane Elisabeth S?lvsten
;
Christian Bendixen
;
Merete Fredholm
;
Arne Lund J?rgensen and Anders Lade Nielsen
关键词:
Neurodegeneration
;
Repeat expansion
;
Ataxia
;
Animal models
;
Genomics
刊名:neurogenetics
出版年:2007
9.
A novel therapeutic strategy for polyglutamine diseases by stabilizing aggregation-prone proteins with small molecules
作者:
Motomasa Tanaka
;
Yoko Machida and Nobuyuki Nukina
关键词:
Polyglutamine
;
Huntington disease
;
Amyloid
;
Trehalose
刊名:Journal of Molecular Medicine
出版年:2005
10.
Expansion of amino acid homo-sequences in proteins: Insights into the role of amino acid homo-polymers and of the protein context in aggregation
作者:
R. P. Menon and A. Pastore
关键词:
Amyloidogenesis
;
ataxin
;
3
;
Josephin
;
misfolding diseases
;
polyglutamine expansion
;
protein aggregation
刊名:Cellular and Molecular Life Sciences (CMLS)
出版年:2006
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