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1. Elucidation of first step of the allylmalonyl-CoA biosynthetic pathway by expression of heterologous KSIII gene and enhancement of 36-methyl-FK506 production by genetic and chemical engineering

作者： SangJoon Mo ; Joo-Won Suh

关键词：36 ; Methyl ; FK506 ; Allylmalonyl ; CoA ; β ; Ketoacyl ; acyl carrier protein synthase III ; FK506 ; Heterologous expression

刊名：Journal of the Korean Society for Applied Biological Chemistry

出版年：2016

2. The biosynthetic pathway of FK506 and its engineering: from past achievements to future prospects

作者： Yeon Hee Ban ; Sung Ryeol Park ; Yeo Joon Yoon

关键词：FK506 ; Biological activity ; Biosynthetic pathway ; Production improvement ; FK506 analogs ; Genetic engineering

刊名：Journal of Industrial Microbiology and Biotechnology

出版年：2016

3. Repair of Neurological Function in Response to FK506 Through CaN/NFATc1 Pathway Following Traumatic Brain Injury in Rats

作者： Qiaoli Wu ; Guodong Liu ; Lixia Xu ; Xiaochang Wen ; Ying Cai…

关键词：FK506 ; Traumatic brain injury ; NFATc1 pathway ; Neurological protection

刊名：Neurochemical Research

出版年：2016

4. Defining the contribution of neuroinflammation to Parkinson’s disease in humanized immune system mice

作者： Gunjan Dhawan Manocha ; Angela Marie Floden ; Kendra Lynn Puig…

关键词：Parkinson’s disease ; Humanized mice ; MPTP ; FK506 ; Neuroinflammation

刊名：Molecular Neurodegeneration

出版年：2017

5. HSP90 is a promising target in gemcitabine and 5-fluorouracil resistant pancreatic cancer

作者： Tarik Ghadban ; Judith L. Dibbern ; Matthias Reeh ; Jameel T. Miro ; Tung Y. Tsui…

关键词：HSP90 ; Pancreatic cancer ; Anti ; tumor therapy ; Geldanamycin ; Target therapy

刊名：Apoptosis

出版年：2017

6. FkbN and Tcs7 are pathway-specific regulators of the FK506 biosynthetic gene cluster in Streptomyces tsukubaensis L19

作者： Xiao-Sheng Zhang ; Hong-Dou Luo ; Yang Tao…

关键词：FK506 ; Streptomyces tsukubaensis ; Biosynthesis ; Regulatory mechanism

刊名：Journal of Industrial Microbiology and Biotechnology

出版年：2016

7. Increased expression of long noncoding RNAs LOC100652951 and LOC100506036 in T cells from patients with rheumatoid arthritis facilitates the inflammatory responses

作者： Ming-Chi Lu ; Hui-Chun Yu ; Chia-Li Yu ; Hsien-Bin Huang ; Malcolm Koo…

关键词：Rheumatoid arthritis ; Long noncoding RNAs ; T cells ; Biologic agent ; LOC100652951 and LOC100506036

刊名：Immunologic Research

出版年：2016

8. Impact of a novel precursor on FK506 production and key gene transcription in Streptomyces tsukubaensis No. 9993

作者： Yan Sun ; Ruifang Ye

关键词：FK506 ; Salicyl alcohol ; RT ; qPCR ; Gene transcription ; Fermentation

刊名：Research on Chemical Intermediates

出版年：2016

9. Effect of FK506 on apoptosis of facial motor neurons in rats and its possible mechanism

作者： Ying Zhang ; Ruoyu Zhang ; Song Qiao ; Jing Fan

关键词：FK506 ; Facial nerve ; Apoptosis ; bcl2 ; Bax

刊名：European Archives of Oto-Rhino-Laryngology

出版年：2016

10. Improvement of FK506 production by synthetic biology approaches

作者： Li-Feng Fu ; Yang Tao ; Mei-Ying Jin ; Hui Jiang

关键词：Biosynthesis ; FK506 ; Phosphopantetheinyl transferase ; Regulator ; Synthetic biology

刊名：Biotechnology Letters

出版年：2016

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