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内部出版物
CNKI学位论文(86)
知网期刊论文(51)
在“
SpringerLink电子期刊
”中,
命中:
13
条,耗时:0.0319858 秒
在所有数据库中总计命中:
137
条
1.
Development and Translational Application of an Integrated, Mechanistic Model of Antibody-
Drug
Conjugate Pharmacokinetics
作者:
Siddharth Sukumaran
;
Crystal Zhang
;
Douglas D. Leipold
;
Ola M. Saad…
关键词:
KEY WORDSantibody
;
drug
conjugate
;
clinical translation
;
drug
deconjugation
;
drug
;
to
;
antibody ratio (DAR)
;
DSTP3086S
;
mathematical modeling
刊名:The AAPS Journal
出版年:2017
2.
Multiscale Modeling of Antibody-
Drug
Conjugates: Connecting Tissue and Cellular Distribution to Whole Animal Pharmacokinetics and Potential Implications for Efficacy
作者:
Cornelius Cilliers
;
Hans Guo
;
Jianshan Liao
;
Nikolas Christodolu…
关键词:
KEY WORDSado
;
trastuzumab emtansine
;
antibody tissue penetration
;
drug
;
antibody ratio (DAR)
;
Herceptin
;
Kadcyla
;
Krogh cylinder
刊名:The AAPS Journal
出版年:2016
3.
Semi-mechanistic Multiple-Analyte Pharmacokinetic Model for an Antibody-
Drug
-Conjugate in Cynomolgus Monkeys
作者:
Dan Lu
;
Jin Yan Jin
;
Sandhya Girish
;
Priya Agarwal
;
Dongwei Li…
关键词:
antibody
;
drug
conjugate
;
integrated modeling
;
multiple analytes
;
pharmacokinetics
刊名:Pharmaceutical Research
出版年:2015
4.
Target-mediated
drug
disposition model and its approximations for antibody–
drug
conjugates
作者:
Leonid Gibiansky (1)
Ekaterina Gibiansky (1)
关键词:
Antibody–
drug
conjugates
;
Target
;
mediated
drug
disposition
;
Quasi
;
steady
;
state approximation
;
Michaelis–Menten approximation
;
Nonlinear pharmacokinetics
;
Identifiability of model parameters
刊名:Journal of Pharmacokinetics and Pharmacodynamics
出版年:2014
5.
A Mechanistic Pharmacokinetic Model Elucidating the Disposition of Trastuzumab Emtansine (T-DM1), an Antibody–
Drug
Conjugate (ADC) for Treatment of Metastatic Breast Cancer
作者:
Brendan Bender
;
Douglas D. Leipold
;
Keyang Xu
;
Ben-Quan Shen…
关键词:
antibody–
drug
conjugate
;
deconjugation
;
population pharmacokinetic model
;
T
;
DM1
;
trastuzumab emtansine
刊名:The AAPS Journal
出版年:2014
6.
Confirmation of diosmetin 3-O-glucuronide as major metabolite of diosmin in humans, using micro-liquid-chromatography–mass spectrometry and ion mobility mass spectrometry
作者:
Luigi Silvestro
;
Isabela Tarcomnicu…
关键词:
Diosmetin
;
Diosmetin glucuronides
;
Liquid chromatography
;
Mass spectrometry
;
Pharmacokinetics
;
Differential ion
;
mobility mass spectrometry
刊名:Analytical and Bioanalytical Chemistry
出版年:2013
7.
An Integrated Multiple-Analyte Pharmacokinetic Model to Characterize Trastuzumab Emtansine (T-DM1) Clearance Pathways and to Evaluate Reduced Pharmacokinetic Sampling in Patients with HER2-Positive Metastatic Breast Cancer
作者:
Dan Lu (1)
Amita Joshi (1)
Bei Wang (1)
Steve Olsen (1)
Joo-Hee Yi (1)
Ian E. Krop (2)
Howard A. Burris (3)
Sandhya Girish (1)
刊名:Clinical Pharmacokinetics
出版年:2013
8.
Alcohol-associated folate disturbances result in altered methylation of folate-regulating genes
作者:
Nissar Ahmad Wani (1)
Abid Hamid (2)
Jyotdeep Kaur (1) jyotdeep2001@yahoo.co.in
关键词:
Folate transport –
;
Gammaglutamyl hydrolase –
;
Folylpolyglutamate synthetase (FPGS) –
;
High resolution melting (HRM) –
;
Methylation –
;
Alcohol
刊名:Molecular and Cellular Biochemistry
出版年:2012
9.
Enterai
Drug
Absorption in Patients with Short Small Bowel
作者:
Dr René Severijnen (1)
Nazila Bayat (1)
Hans Bakker (2)
Jules Tolboom (3)
Ger Bongaerts (4)
刊名:Clinical Pharmacokinetics
出版年:2004
10.
In-vivo indices of CYP2D6 activity: comparison of dextromethorphan metabolic ratios in 4-h urine and 3-h plasma
作者:
J. Chládek
;
G. Zimová
;
M. Beránek and J. Martínková
刊名:European Journal of Clinical Pharmacology
出版年:2000
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