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NATURE电子期刊(1)
Elsevier电子期刊(6)
ACS电子期刊(12)
在“
ACS电子期刊
”中,
命中:
12
条,耗时:小于0.01 秒
在所有数据库中总计命中:
19
条
1.
Small Molecule Disruptors of the Glucokinase鈥揋lucokinase Regulatory Protein Interaction: 5. A Novel Aryl Sulfone Series, Optimization Through Conformational Analysis
作者:
Nuria A. Tamayo
;
Mark H. Norman
;
Michael D. Bartberger
;
Fang-Tsao Hong
;
Yunxin Bo
;
Longbin Liu
;
Nobuko Nishimura
;
Kevin C. Yang
;
Seifu Tadesse
;
Christopher Fotsch
;
Jie Chen
;
Samer Chmait
;
Rod Cupples
;
Clarence
Hale
;
Steven R. Jordan
;
David J. Lloyd
;
Glenn Sivits
;
Gwyneth Van
;
David J. St. Jean
;
Jr.
刊名:Journal of Medicinal Chemistry
出版年:2015
2.
Discovery and Structure-Guided Optimization of Diarylmethanesulfonamide Disrupters of Glucokinase–Glucokinase Regulatory Protein (GK–GKRP) Binding: Strategic Use of a N → S (nN → σ*S–X) Interaction fo
作者:
Lewis D. Pennington
;
Michael D. Bartberger
;
Michael D. Croghan
;
Kristin L. Andrews
;
Kate S. Ashton
;
Matthew P. Bourbeau
;
Jie Chen
;
Samer Chmait
;
Rod Cupples
;
Christopher Fotsch
;
Joan Helmering
;
Fang-Tsao Hong
;
Randall W. Hungate
;
Steven R. Jordan
;
Ke Kong
;
Longbin Liu
;
Klaus Michelsen
;
Carolyn Moyer
;
Nobuko Nishimura
;
Mark H. Norman
;
Andreas Reichelt
;
Aaron C. Siegmund
;
Glenn Sivits
;
Seifu Tadesse
;
Christopher M. Tegley
;
Gwyneth Van
;
Kevin C. Yang
;
Guomin Yao
;
Jiandong Zhang
;
David J. Lloyd
;
Clarence
Hale
;
David J. St. Jean Jr.
刊名:Journal of Medicinal Chemistry
出版年:2015
3.
Small Molecule Disruptors of the Glucokinase鈥揋lucokinase Regulatory Protein Interaction: 3. Structure鈥揂ctivity Relationships within the Aryl Carbinol Region of the N-Arylsulfonamido-N鈥?a
作者:
Nobuko Nishimura
;
Mark H. Norman
;
Longbin Liu
;
Kevin C. Yang
;
Kate S. Ashton
;
Michael D. Bartberger
;
Samer Chmait
;
Jie Chen
;
Rod Cupples
;
Christopher Fotsch
;
Joan Helmering
;
Steven R. Jordan
;
Roxanne K. Kunz
;
Lewis D. Pennington
;
Steve F. Poon
;
Aaron Siegmund
;
Glenn Sivits
;
David J. Lloyd
;
Clarence
Hale
;
David J. St. Jean
;
Jr.
刊名:Journal of Medicinal Chemistry
出版年:2014
4.
Small Molecule Disruptors of the Glucokinase鈥揋lucokinase Regulatory Protein Interaction: 4. Exploration of a Novel Binding Pocket
作者:
Fang-Tsao Hong
;
Mark H. Norman
;
Kate S. Ashton
;
Michael D. Bartberger
;
Jie Chen
;
Samer Chmait
;
Rod Cupples
;
Christopher Fotsch
;
Steven R. Jordan
;
David J. Lloyd
;
Glenn Sivits
;
Seifu Tadesse
;
Clarence
Hale
;
David J. St. Jean
;
Jr.
刊名:Journal of Medicinal Chemistry
出版年:2014
5.
Small Molecule Disruptors of the Glucokinase–Glucokinase Regulatory Protein Interaction: 2. Leveraging Structure-Based Drug Design to Identify Analogues with Improved Pharmacokinetic Profiles
作者:
David J. St. Jean
;
Jr.
;
Kate S. Ashton
;
Michael D. Bartberger
;
Jie Chen
;
Samer Chmait
;
Rod Cupples
;
Elizabeth Galbreath
;
Joan Helmering
;
Fang-Tsao Hong
;
Steven R. Jordan
;
Longbin Liu
;
Roxanne K. Kunz
;
Klaus Michelsen
;
Nobuko Nishimura
;
Lewis D. Pennington
;
Steve F. Poon
;
Darren Reid
;
Glenn Sivits
;
Markian M. Stec
;
Seifu Tadesse
;
Nuria Tamayo
;
Gwyneth Van
;
Kevin C. Yang
;
Jiandong Zhang
;
Mark H. Norman
;
Christopher Fotsch
;
David J. Lloyd
;
Clarence
Hale
刊名:Journal of Medicinal Chemistry
出版年:2014
6.
Small Molecule Disruptors of the Glucokinase–Glucokinase Regulatory Protein Interaction: 1. Discovery of a Novel Tool Compound for in Vivo Proof-of-Concept
作者:
Kate S. Ashton
;
Kristin L. Andrews
;
Marion C. Bryan
;
Jie Chen
;
Kui Chen
;
Michelle Chen
;
Samer Chmait
;
Michael Croghan
;
Rod Cupples
;
Christopher Fotsch
;
Joan Helmering
;
Steve R. Jordan
;
Robert J. M. Kurzeja
;
Klaus Michelsen
;
Lewis D. Pennington
;
Steve F. Poon
;
Glenn Sivits
;
Gwyneth Van
;
Steve L. Vonderfecht
;
Robert C. Wahl
;
Jiandong Zhang
;
David J. Lloyd
;
Clarence
Hale
;
David J. St. Jean
;
Jr.
刊名:Journal of Medicinal Chemistry
出版年:2014
7.
Correction to Small Molecule Disruptors of the Glucokinase鈥揋lucokinase Regulatory Protein Interaction: 1. Discovery of a Novel Tool Compound for in Vivo Proof-of-Concept
作者:
Kate S. Ashton
;
Kristin L. Andrews
;
Marian C. Bryan
;
Jie Chen
;
Kui Chen
;
Michelle Chen
;
Samer Chmait
;
Michael Croghan
;
Rod Cupples
;
Christopher Fotsch
;
Joan Helmering
;
Steve R. Jordan
;
Robert J. M. Kurzeja
;
Klaus Michelsen
;
Lewis D. Pennington
;
Steve F. Poon
;
Glenn Sivits
;
Gwyneth Van
;
Steve L. Vonderfecht
;
Robert C. Wahl
;
Jiandong Zhang
;
David J. Lloyd
;
Clarence
Hale
;
David J. St. Jean
;
Jr.
刊名:Journal of Medicinal Chemistry
出版年:2014
8.
Discovery of a Potent, Orally Active 11β-Hydroxysteroid Dehydrogenase Type 1 Inhibitor for Clinical Study: Identification of (S)-2-((1S,2S,4R)-Bicyclo[2.2.1]heptan-2-y
作者:
Murielle M. Vniant
;
Clarence
Hale
;
Randall W. Hungate
;
Kyung Gahm
;
Maurice G. Emery
;
Janan Jona
;
Smriti Joseph
;
Jeffrey Adams
;
Andrew Hague
;
George Moniz
;
Jiandong Zhang
;
Michael D. Bartberger
;
Vivian
刊名:Journal of Medicinal Chemistry
出版年:2010
9.
2-Amino-1,3-thiazol-4(5H)-ones as Potent and Selective 11β-Hydroxysteroid Dehydrogenase Type 1 Inhibitors: Enzyme−Ligand Co-Crystal Structure and Demonstration of Pharmacodynamic E
作者:
Lars Johansson
;
Christopher Fotsch
;
Michael D. Bartberger
;
Victor M. Castro
;
Michelle Chen
;
Maurice Emery
;
Sonja Gustafsson
;
Clarence
Hale
;
Dean Hickman
;
Evert Homan
;
Steven R. Jordan
;
Renee Komorowsk
刊名:Journal of Medicinal Chemistry
出版年:2008
10.
Further Studies with the 2-Amino-1,3-thiazol-4(5H)-one Class of 11β-Hydroxysteroid Dehydrogenase Type 1 Inhibitors: Reducing Pregnane X Receptor Activity and Exploring Activity in a Monkey
作者:
Christopher Fotsch
;
Michael D. Bartberger
;
Eric A. Bercot
;
Michelle Chen
;
Rod Cupples
;
Maury Emery
;
Jenne Fretland
;
Anil Guram
;
Clarence
Hale
;
Nianhe Han
;
Dean Hickman
;
Randall W. Hungate
;
Michael Hay
刊名:Journal of Medicinal Chemistry
出版年:2008
1
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