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Wiley电子期刊(25)	SpringerLink电子期刊(726)	NATURE电子期刊(14)	ACS电子期刊(76)
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在“Elsevier电子期刊”中，命中：1,464条，耗时：0.0159922 秒

在所有数据库中总计命中：2,307条

1.Novel CLK1 inhibitors based on N-aryloxazol-2-amine skeleton - A possible way to dual VEGFR2 TK/CLK ligands

作者：Miroslav Murá ; r^a ; Juraj Dobia&scaron ; ^a ; Peter &Scaron ; ramel^a ; ^c ; Gabriela Addová ; ^b ; Gilles Hanquet^c ; Andrej Bohá ; č^a ; ^d ; ^{andrej.bohac@fns.uniba.sk}

关键词：Dual CLK1/VEGFR2 kinase ligands ; CDK9 ; GSK3 ; DYRK1A ; GSK3α/β ; Muti-targeted kinase inhibitors

刊名：European Journal of Medicinal Chemistry

出版年：2017

2.Design and discovery of 4-anilinoquinazoline-urea derivatives as dual TK inhibitors of EGFR and VEGFR-2

作者：Hai-Qi Zhang¹ ; Fei-Hu Gong¹ ; Ji-Qing Ye ; Chi Zhang ; Xiao-Hong Yue ; Chuan-Gui Li ; Yun-Gen Xu ; Li-Ping Sun

关键词：4-Anilinoquinazoline-urea ; EGFR ; VEGFR-2 ; Tyrosine kinase inhibitor ; Antitumor

刊名：European Journal of Medicinal Chemistry

出版年：2017

3.The marine-derived pachycladin diterpenoids as novel inhibitors of wild-type and mutant EGFR

作者：Mohamed M. Mohyeldin ^{mohyelmm@warhawks.ulm.edu} ; Mohamed R. Akl ^{mohamedreda_pharmacy@yahoo.com} ; Abu Bakar Siddique ; Hossam M. Hassan¹ ; ^{abuh20050@yahoo.com} ; Khalid A. El Sayed ; ^{elsayed@ulm.edu}

关键词：ATCC ; American type culture collection ; CD30 ; cluster of differentiation 30 a type I transmembrane glycoprotein belonging to the TNF receptor superfamily ; CD31 ; platelet endothelial cell adhesion molecule 1 ; EGF ; epidermal growth factor ; EPHB4 ; ephrin type-B receptor 4 ; ERK ; extracellular signal-regulated kinase ; FGFR ; fibroblast growth factor receptor ; FLT3 ; fms-related tyrosine kinase 3 ; JAK2 ; janus kinase 2 ; L858R ; leucine 858 mutated to arginine ; L861Q ; leucine 861 mutated to glutamine ; M ; m

刊名：Biochemical Pharmacology

出版年：2017

4.Targeted Inhibition of EGFR and Glutaminase Induces Metabolic Crisis in EGFR Mutant Lung Cancer

作者：Milica Momcilovic¹ ; ¹⁰ ; Sean T. Bailey¹ ; ¹⁰ ; Jason T. Lee³ ; Michael C. Fishbein² ; Clara Magyar² ; Daniel Braas³ ; ⁶ ; Thomas Graeber³ ; ⁵ ; ⁶ ; Nicholas J. Jackson⁷ ; Johannes Czernin³ ; ⁵ ; Ethan Emberley⁹ ; Matthew Gross⁹ ; Julie Janes⁹ ; Andy Mackinnon⁹ ; Alison Pan⁹ ; Mirna Rodriguez⁹ ; Melissa Works⁹ ; Winter Zhang⁹ ; Francesco Parlati⁹ ; Susan Demo⁹ ; Edward Garon⁴ ; ⁵ ; Kostyantyn Krysan¹ ; Tonya C. Walser¹ ; Steven M. Dubinett¹ ; ² ; ⁵ ; Saman Sadeghi³ ; Heather R. Christofk³ ; ⁵ ; ⁶ ; ⁸ ; David B. Shackelford¹ ; ⁵ ; ¹¹ ; ^{dshackelford@mednet.ucla.edu}

关键词：EGFR ; lung cancer ; glutamine ; erlotinib ; CB-839 ; PET imaging ; AMPK ; metabolic crisis

刊名：Cell Reports

出版年：2017

5.Shikonin inhibits gefitinib-resistant non-small cell lung cancer by inhibiting TrxR and activating the EGFR proteasomal degradation pathway

作者：Xia Li¹ ; Xing-Xing Fan¹ ; Ze-Bo Jiang ; Wings TY Loo ; Xiao-Jun Yao ; Elaine Lai-Han Leung ; ^{lhleung@must.edu.mo} ; Louis WC Chow ; ^{wcchow@must.edu.mo} ; Liang Liu ; ^{lliu@must.edu.mo}

关键词：NSCLC ; non-small cell lung cancer cell ; ROS ; reactive oxygen species ; EGFR ; epidermal growth factor receptor ; T790M ; a substitution mutation of threonine with methionine at position 790 of EGFR ; TrxR ; thioredoxin reductases ; MTT ; 3-(4 ; 5-dimetrylthiazol)-2 ; 5-diphenyltetrazolium bromide ; DCFDA ; dichlorofluorescein diacetate ; PBS ; phosphate-buffered saline ; RIPA ; radioimmunoprecipitation assay ; PARP ; poly (ADP-ribosyl) polymerase ; NAC ; N-acetyl-l-cysteine ; MG132 ; proteasomal degradation pathway inh

刊名：Pharmacological Research

出版年：2017

6.A structure-guided optimization of pyrido[2,3-d]pyrimidin-7-ones as selective inhibitors of EGFR^L858R/T790M mutant with improved pharmacokinetic properties

作者：Lei Yu^a ; ^b ; Minhao Huang^a ; ^b ; Tianfeng Xu^a ; ^b ; Linjiang Tong^d ; Xiao-e Yan^e ; Zhang Zhang^a ; Yong Xu^a ; Caihong Yun^e ; Hua Xie^d ; ^{hxie@simm.ac.cn} ; Ke Ding^a ; ^c ; ^{ding_ke@gibh.ac.cn} ; Xiaoyun Lu^c ; ^{luxy2016@jnu.edu.cn}

关键词：EGFRT790M mutant ; Pyrido[2 ; 3-d]pyrimidin-7-ones ; Pharmacokinetic property ; NSCLC ; Irreversible inhibitor

刊名：European Journal of Medicinal Chemistry

出版年：2017

7.Continuing EGFR inhibition beyond progression in advanced non-small cell lung cancer

作者：Timothy A. Yap^a ; ^b ; Aislinn Macklin-Doherty^a ; Sanjay Popat^a ; ^c ; ^{sanjay.popat@rmh.nhs.uk}

关键词：EGFR mutant NSCLC ; Treatment beyond progression

刊名：European Journal of Cancer

出版年：2017

8.Systematic Identification of Oncogenic EGFR Interaction Partners

作者：Julia Petschnigg¹ ; Max Kotlyar² ; Louise Blair¹ ; Igor Jurisica² ; ³ ; ⁴ ; ⁵ ; Igor Stagljar⁶ ; ⁷ ; ⁸ ; Robin Ketteler¹ ; ^{r.ketteler@ucl.ac.uk}

关键词：EGF ; epidermal growth factor ; EGFR ; epidermal growth factor receptor ; ERK ; extracellular signal-regulated kinase ; GFP ; green fluorescent protein ; Grb2 ; growth factor receptor-bound protein 2 ; SH ; Src homology ; MAPK ; mitogen-activated protein kinase ; TK ; tyrosine kinase ; TKI ; TK inhibitor ; NSCLC ; non-small cell lung cancer ; MaMTH ; mammalian membrane two-hybrid ; TACC ; transforming acidic coiled-coil protein ; GO ; gene ontology ; Cub ; C-terminal half of ubiquitin ; TF ; transcription factor ; Nub ; N-ter

刊名：Journal of Molecular Biology

出版年：2017

9.Design, synthesis, docking and QSAR study of substituted benzimidazole linked oxadiazole as cytotoxic agents, EGFR and erbB2 receptor inhibitors

作者：Md Jawaid Akhtar^a ; Anees Ahmad Siddiqui^a ; Ahsan Ahmed Khan^a ; Zulphikar Ali^a ; Rikeshwer Prasad Dewangan^b ; Santosh Pasha^b ; M. Shahar Yar^a ; ^{yarmsy@rediffmail.com}

关键词：Benzimidazole linked oxadiazole ; Anticancer ; Apoptosis ; 3D-QSAR studies

刊名：European Journal of Medicinal Chemistry

出版年：2017

10.EAI045: The fourth-generation EGFR inhibitor overcoming T790M and C797S resistance

作者：Shuhang Wang^a ; Yongping Song^b ; Delong Liu^b ; ^{delong_liu@nymc.edu}

关键词：EGFR ; EAI045 ; TKI ; AZD9291 ; Rociletinib

刊名：Cancer Letters

出版年：2017

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