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Wiley电子期刊(3)
NATURE电子期刊(1)
ACS电子期刊(9)
SpringerLink电子期刊(2)
Elsevier电子期刊(25)
在“
Elsevier电子期刊
”中,
命中:
25
条,耗时:小于0.01 秒
在所有数据库中总计命中:
40
条
1.
Identification of azabenzimidazoles as potent JAK1 selective inhibitors
作者:
Melissa M. Vasbinder
a
;
melissa.vasbinder@astrazeneca.com" class="auth_mail" title="E-mail the corresponding author
;
Marat Alimzhanov
a
;
Martin Augustin
d
;
Geraldine Bebernitz
a
;
Kirsten Bell
a
;
Claudio Chuaqui
a
;
Tracy Deegan
a
;
Andrew D. Ferguson
b
;
Kelly Goodwin
a
;
Dennis Huszar
a
;
Aarti Kawatkar
a
;
Sameer Kawatkar
a
;
Jon Read
c
;
Jie Shi
a
;
Stefan
Steinbacher
d
;
Holger Steuber
d
;
Qibin Su
a
;
Dorin Toader
a
;
Haixia Wang
a
;
Richard Woessner
a
;
Allan Wu
b
;
Minwei Ye
a
;
Michael Zinda
a
关键词:
Azabenzimidazoles
;
JAK1
;
JAK selectivity
;
JAK1 inhibitors
刊名:Bioorganic & Medicinal Chemistry Letters
出版年:2016
2.
Kinetic and structural insights into the binding of histone deacetylase 1 and 2 (HDAC1, 2) inhibitors
作者:
Florence F. Wagner
a
;
fwagner@broadinstitute.org" class="auth_mail" title="E-mail the corresponding author
;
Michel Weï
;
wer
a
;
Stefan
Steinbacher
b
;
Adrian Schomburg
b
;
Peter Reinemer
b
;
Jennifer P. Gale
a
;
Arthur J. Campbell
a
;
Stewart L. Fisher
c
;
Wen-Ning Zhao
d
;
Surya A. Reis
d
;
Krista M. Hennig
d
;
Mé
;
ryl Thomas
a
;
Peter Mü
;
ller
e
;
Martin R. Jefson
f
;
Daniel M. Fass
d
;
Stephen J. Haggarty
d
;
Yan-Ling Zhang
a
;
Edward B. Holson
a
;
&dagger
;
;
EHolson@atlasventure.com" class="auth_mail" title="E-mail the corresponding author
关键词:
HATs
;
histone acetyl transferases
;
HDACs
;
histone deacetylases
;
SAR
;
structure activity relationship
;
SKR
;
structure kinetic relationship
;
T1/2
;
half-life
刊名:Bioorganic & Medicinal Chemistry
出版年:2016
3.
Isosteric replacements for benzothiazoles and optimisation to potent Cathepsin K inhibitors free from hERG channel inhibition
作者:
Alex
;
er G. Dossetter
;
Jonathan Bowyer
;
Calum R. Cook
;
James J. Crawford
;
Jonathan E. Finlayson
;
Nicola M. Heron
;
Christine Heyes
;
Adrian J. Highton
;
Julian A. Hudson
;
Anja Jestel
;
Stephan Krapp
;
Philip A. MacFaul
;
Thomas M. McGuire
;
Andrew D. Morley
;
Jeffrey J. Morris
;
Ken M. Page
;
Lyn Rosenbrier Ribeiro
;
Helen Sawney
;
Stefan
Steinbacher
;
Caroline Smith
;
et al.
关键词:
Cathepsin K
;
Covalent inhibitor
;
Molecular complexity
;
Structure based design
;
hERG
;
Pharmacokinetics
;
Matched molecular pair analysis
;
MMPA
;
Synthesis
刊名:Bioorganic and Medicinal Chemistry Letters
出版年:2012
4.
NSAID-derived γ-secretase modulation requires an acidic moiety on the carbazole scaffold
作者:
Andrea Zall
a
;
Daniel Kieser
a
;
Nicole Hö
;
ttecke
a
;
Eva C. Naumann
a
;
Binia Thomaszewski
a
;
Katrin Schneider
a
;
Dirk T.
Steinbacher
a
;
Robert Schubenel
b
;
Stefan
Masur
b
;
Karlheinz Baumann
b
;
Boris Schmidt
a
;
Schmidt_boris@mac.com"" rel=""nofollow
关键词:
Alzheimer’
;
s disease
;
γ
;
-Secretase modulation
;
Carboxylic acid isosteres
;
Carprofen
刊名:Bioorganic and Medicinal Chemistry
出版年:2011
5.
A combined spectroscopic and crystallographic approach to probing drug–human serum albumin interactions
作者:
David Buttar
;
Nicola Colclough
;
Stefan
Gerhardt
;
Philip A. MacFaul
;
Scott D. Phillips
;
Alleyn Plowright
;
Paul Whittamore
;
Kin Tam
;
Klaus Maskos
;
Stefan
Steinbacher
;
Holger Steuber
关键词:
Drug
;
Binding
;
Albumin
;
Fluorescence
;
Subdomain IB
;
Crystallography
刊名:Bioorganic and Medicinal Chemistry
出版年:2010
6.
Conventional MRI and
1
H MR spectroscopy in primary central nervous system lymphoma
作者:
Stefan
Martin Golaszewski
;
Stefan
ie Klein
;
Alex
;
er Baden Kunz
;
Mark Mc Coy
;
Jü
;
rgen
Steinbacher
;
Serge Weis
;
Gunther Ladurner
;
Raffaele Nardone
关键词:
Magnetic resonance imaging
;
Magnetic resonance spectroscopy
;
Primary CNS lymphoma
刊名:European Journal of Radiology Extra
出版年:2010
7.
Design of selective Cathepsin inhibitors
作者:
Paul A. Bethel
;
Stefan
Gerhardt
;
Emma V. Jones
;
Peter W. Kenny
;
Galith I. Karoutchi
;
Andrew D. Morley
;
Keith Oldham
;
Neil Rankine
;
Martin Augustin
;
Stephan Krapp
;
Hannes Simader
;
Stefan
Steinbacher
关键词:
Cathepsin
;
Cathepsin B
;
Cathepsin K
;
Cathepsin L
;
Cathepsin L2
;
Cathepsin S
;
Cathepsin V
;
Cysteine protease
;
Nitrile
;
Covalent inhibitor
;
Selectity
;
Protein structure
;
X-ray crystallography
;
Structure-based design
;
Hydrogen bonding
;
Hot spot
;
Electrostati
刊名:Bioorganic and Medicinal Chemistry Letters
出版年:2009
8.
Structure of the Murine Unglycosylated IgG1 Fc Fragment
作者:
Matthias J. Feige
;
Susanne Nath
;
Silvia R. Catharino
;
Daniel Weinfurtner
;
Stefan
Steinbacher
;
Johannes Buchner
关键词:
IgG1
;
antibody structure
;
glycosylation
;
antibody stability
;
antibody effector functions
刊名:Journal of Molecular Biology
出版年:2009
9.
Road vehicle emissions of molecular hydrogen (H
2
) from a tunnel study
作者:
Martin K. Vollmer
;
Niklas Juergens
;
Martin
Steinbacher
;
Stefan
Reimann
;
Martin Weilenmann
;
Brigitte Buchmann
关键词:
Emission factor
;
H
2
/CO ratio
;
H
2
/CO
2
ratio
;
Global emissions
;
Traffic emission
刊名:Atmospheric Environment
出版年:2007
10.
Potential Anti-infective Targets in Pathogenic Yeasts: Structure and Properties of 3,4-Dihydroxy-2-butanone 4-phosphate Synthase of
Candida albicans
作者:
Echt
;
Stefan
ie
;
Bauer
;
Stefan
ie
;
Steinbacher
;
Stefan
;
Huber
;
Robert
;
Bacher
;
Adelbert
;
Fischer
;
Markus
关键词:
Candida albicans
;
riboflavin biosynthesis
;
3
;
4-dihydroxy-2-butanone 4-phosphate synthase
;
crystal structure
;
synthetic gene
;
CA
;
Candida albicans
;
CD
;
circular dichroism
;
DHBP
;
l-3
;
4-dihydroxy-2-butanone 4-phosphate
;
DHBPS
;
3
;
4-dihydroxy-2-b
刊名:Journal of Molecular Biology
出版年:2004
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