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Wiley电子期刊(13)	NATURE电子期刊(11)	ACS电子期刊(221)
SpringerLink电子期刊(320)	Elsevier电子期刊(1176)

在“Elsevier电子期刊”中，命中：1,176条，耗时：小于0.01 秒

在所有数据库中总计命中：1,741条

1.Extended substrate specificity and first potent irreversible inhibitor/activity-based probe design for Zika virus NS2B-NS3 protease

作者：Wioletta Rut^a ; Linlin Zhang^b ; ^c ; Paulina Kasperkiewicz^a ; ^d ; Marcin Poreba^a ; ^d ; Rolf Hilgenfeld^b ; ^c ; Marcin Drąg^a ; ^{marcin.drag@pwr.edu.pl}

关键词：Irreversible inhibitor ; Proteolytic enzyme ; ZIKA ; Substrate specificity

刊名：Antiviral Research

出版年：2017

2.Development of fluorine-18 labeled peptidic PET tracers for imaging active tissue transglutaminase

作者：Berend van der Wildt^a ; ^b ; ^{b.vanderwildt@vumc.nl} ; Micha M.M. Wilhelmus^b ; Esther J.M. Kooijman^a ; Cornelis A.M. Jongenelen^b ; Robert C. Schuit^a ; Christian Bü ; chold^c ; Ralf Pasternack^c ; Adriaan A. Lammertsma^a ; Benjamin Drukarch^b ; Albert D. Windhorst^a

关键词：Tissue transglutaminase ; TG2 ; Fluorine-18 ; Irreversible TG2 inhibitors ; MDA-MB-231

刊名：Nuclear Medicine and Biology

出版年：2017

3.A structure-guided optimization of pyrido[2,3-d]pyrimidin-7-ones as selective inhibitors of EGFR^L858R/T790M mutant with improved pharmacokinetic properties

作者：Lei Yu^a ; ^b ; Minhao Huang^a ; ^b ; Tianfeng Xu^a ; ^b ; Linjiang Tong^d ; Xiao-e Yan^e ; Zhang Zhang^a ; Yong Xu^a ; Caihong Yun^e ; Hua Xie^d ; ^{hxie@simm.ac.cn} ; Ke Ding^a ; ^c ; ^{ding_ke@gibh.ac.cn} ; Xiaoyun Lu^c ; ^{luxy2016@jnu.edu.cn}

关键词：EGFRT790M mutant ; Pyrido[2 ; 3-d]pyrimidin-7-ones ; Pharmacokinetic property ; NSCLC ; Irreversible inhibitor

刊名：European Journal of Medicinal Chemistry

出版年：2017

4.An overview of the binding models of FGFR tyrosine kinases in complex with small molecule inhibitors

作者：Weiyan Cheng^a ; Mixiang Wang^b ; Xin Tian^a ; ^{tianx@zzu.edu.cn} ; Xiaojian Zhang^a ; ^{firstpha@163.com}

关键词：FGFR ; Small molecule inhibitor ; Crystal structure ; DFG-in/out ; Irreversible ; Pharmacological activity

刊名：European Journal of Medicinal Chemistry

出版年：2017

5.Compound Selectivity and Target Residence Time of Kinase Inhibitors Studied with Surface Plasmon Resonance

作者：Nicole Willemsen-Seegers¹ ; Joost C.M. Uitdehaag¹ ; Martine B.W. Prinsen¹ ; Judith R.F. de Vetter¹ ; Jos de Man¹ ; Masaaki Sawa² ; Yusuke Kawase² ; Rogier C. Buijsman¹ ; Guido J.R. Zaman¹ ; ^{guido.zaman@ntrc.nl}

关键词：FDA ; US Food and Drug Administration ; EGFR ; epidermal growth factor receptor ; BTK ; Bruton's tyrosine kinase ; SPR ; surface plasmon resonance ; PI3K ; phosphoinositide 3-kinase ; SD ; standard deviation ; SE ; standard error ; PI3K ; phosphoinositide 3-kinase ; SPR ; surface plasmon resonance

刊名：Journal of Molecular Biology

出版年：2017

6.mTOR Inhibition Mitigates Molecular and Biochemical Alterations of Vigabatrin-Induced Visual Field Toxicity in Mice

作者：Kara R. Vogel ; PhD^a ; Garrett R. Ainslie ; PhD^a ; Michelle A. Schmidt ; MS^b ; Jonathan P. Wisor ; PhD^b ; K. Michael Gibson ; PhD^a ; ^{mike.gibson@wsu.edu}

关键词：vigabatrin ; GABA ; mTOR ; gene expression ; visual evoked potentials ; visual field loss ; ARPE19 cells ; epilepsy

刊名：Pediatric Neurology

出版年：2017

7.Phosphonate-based irreversible inhibitors of human γ-glutamyl transpeptidase (GGT). GGsTop is a non-toxic and highly selective inhibitor with critical electrostatic interaction with an active-site residue Lys562 for enhanced inhibitory activity

作者：Akane Kamiyama^a ; ^&dagger ; ; Mado Nakajima^a ; ^&Dagger ; ; Liyou Han^a ; ^§ ; ; Kei Wada^b ; Masaharu Mizutani^a ; ^¶ ; ; Yukiko Tabuchi^a ; ^‖ ; Akiko Kojima-Yuasa^c ; Isao Matsui-Yuasa^c ; Hideyuki Suzuki^d ; Keiichi Fukuyama^e ; ^&dagger ; &dagger ; ; Bunta Watanabe^a ; ^&Dagger ; &Dagger ; ; ^{bunta@scl.kyoto-u.ac.jp" class="auth_mail" title="E-mail the corresponding author} ; Jun Hiratake^a ; ^&Dagger ; &Dagger ; ; ^{hiratake@scl.kyoto-u.ac.jp" class="auth_mail" title="E-mail the corresponding author}

关键词：γ-Glutamyl transpeptidase ; Phosphonate diesters ; GGsTop ; Mechanism-based inhibitor ; Electrostatic interaction ; Active-site residue Lys562 ; Selectivity ; Cytotoxicity

刊名：Bioorganic & Medicinal Chemistry

出版年：2016

8.Identification of a benzo imidazole thiazole derivative as the specific irreversible inhibitor of protein tyrosine phosphatase

作者：Lin Ge^a ; ^c ; ^&dagger ; ; Kang-shuai Li^a ; ^c ; ^&dagger ; ; Meng-meng Li^a ; Peng Xiao^a ; ^b ; Xu-ben Hou^b ; Xu Chen^c ; Hong-da Liu^a ; Amy Lin^d ; Xiao Yu^c ; Gui-jie Ren^a ; ^{rengj@sdu.edu.cn" class="auth_mail" title="E-mail the corresponding author} ; Hao Fang^b ; ^{haofangcn@sdu.edu.cn" class="auth_mail" title="E-mail the corresponding author} ; Jin-peng Sun^a ; ^{sunjinpeng@sdu.edu.cn" class="auth_mail" title="E-mail the corresponding author}

关键词：PTP ; STEP ; Covalent inhibitor ; Irreversible ; Probe

刊名：Bioorganic & Medicinal Chemistry Letters

出版年：2016

9.Liquid chromatography-tandem mass spectrometric assay for the simultaneous determination of the irreversible BTK inhibitor ibrutinib and its dihydrodiol-metabolite in plasma and its application in mouse pharmacokinetic studies

作者：Johannes J.M. Rood^a ; ^{j.j.m.rood@uu.nl" class="auth_mail" title="E-mail the corresponding author} ; Stephanie van Hoppe^b ; Alfred H. Schinkel^b ; Jan H.M. Schellens^a ; ^c ; Jos H. Beijnen^a ; ^c ; ^d ; Rolf W. Sparidans^a

关键词：BCR ; B-cell antigen receptor ; BSA ; bovine serum albumin ; BTK ; Bruton&rsquo ; s tyrosine kinase ; CHMP ; Committee for Medicinal Products for Human Use ; DHI ; dhihydrodiol-ibrutinib ; DMSO ; dimethyl Sulphoxide ; EMA ; European Medicines Agency ; ErbB2 ; receptor tyrosine-protein kinase erbB-2 ; ESI ; electro spray ionization ; FDA ; Food and Drug Administration ; LC&ndash ; MS/MS ; liquid chromatography&ndash ; tandem mass spectrometry ; LLOQ ; lower limit of quantitation ; MRP1 ; multidrug resistance protein 1 ; PP ; pol

刊名：Journal of Pharmaceutical and Biomedical Analysis

出版年：2016

10.A Prospective Clinical Pilot Study on the Level of Matrix Metalloproteinase-9 in Dental Pulpal Blood as a Marker for the State of Inflammation in the Pulp Tissue

作者：Johannes Mente ; Priv-Doz ; Dr med dent^&lowast ; ; ^{johannes.mente@med.uni-heidelberg.de" class="auth_mail" title="E-mail the corresponding author} ; Jelena Petrovic^&lowast ; ; Holger Gehrig ; Dr med dent ; MSc^&lowast ; ; Sarah Rampf ; Dr med dent^&lowast ; ; Annemarie Michel ; Dr med dent^&lowast ; ; Alexander Schü ; rz^&lowast ; ; Thorsten Pfefferle ; Dr med dent^&lowast ; ; Daniel Saure ; Dr rer nat ; MSc^&dagger ; ; Ralf Erber ; Dr sc hum^&Dagger ;

关键词：Clinical diagnosis ; irreversible pulpitis ; matrix metalloproteinase-9 ; pulp tissue inflammation ; reversible pulpitis

刊名：Journal of Endodontics

出版年：2016

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