设为首页
收藏本站
网站地图
|
English
|
公务邮箱
About the library
Background
History
Leadership
Organization
Readers' Guide
Opening Hours
Collections
Help Via Email
Publications
Electronic Information Resources
常用资源
电子图书
期刊论文
学位会议
外文资源
特色专题
内部出版物
在“
Elsevier电子期刊
”中,
命中:
109
条,耗时:小于0.01 秒
1.
Chemical synthesis and biological evaluation of ω-hydroxy polyunsaturated fatty acids
作者:
Sung Hee Hwang
a
;
Karen Wagner
a
;
Jian Xu
b
;
Jun Yang
a
;
Xichun Li
b
;
Zhengyu Cao
b
;
Christophe Morisseau
a
;
Kin Sing Stephen Lee
a
;
Bruce D. Hammock
a
;
bdhammock@ucdavis.edu
关键词:
ARA
;
arachidonic acid
;
COX
;
cyclooxygenase
;
CYP 450
;
cytochrome P450
;
DHA
;
docosahexaenoic acid
;
EPA
;
eicosapentaenoic acid
;
FLIPR
;
fluorescent imaging plate reader
;
22-HDoHE
;
22-hydroxydocosahexaenoic acid
;
20-HEPE
;
20-hydroxyeicosapentaenoic acid
;
20-HETE
;
20-hydroxyeicosatetranoic acid
;
PUFA
;
polyunsaturated fatty acids
;
TRPV1
;
transient receptor potential vanilloid 1
刊名:Bioorganic & Medicinal Chemistry Letters
出版年:2017
2.
Assessment of extracellular field potential and Ca
2 +
transient signals for early QT/pro-arrhythmia detection using human induced pluripotent stem cell-derived cardiomyocytes
作者:
Najah Abi-Gerges
a
;
1
;
najah.abigeorges@hotmail.com
;
Amy Pointon
a
;
Karen L. Oldman
b
;
Martin R. Brown
b
;
Mark A. Pilling
b
;
Clare E. Sefton
b
;
Helen Garside
c
;
Christopher E. Pollard
a
关键词:
Human stem cell-derived cardiomyocytes
;
Extracellular field potential
;
Ca2
;
+ transient
;
QT prolongation
;
Pro-arrhythmia
;
Cardiac safety
;
Drug discovery and development
刊名:Journal of Pharmacological and Toxicological Methods
出版年:2017
3.
Differential Regulation of CXCL8 Production by Different G Protein Subunits with Synergistic Stimulation by G
i
- and G
q
-Regulated Pathways
作者:
Anthony S.L. Chan
1
;
Winnie W.I. Lau
1
;
Aydan C.H. Szeto
1
;
Jiuling Wang
1
;
Yung H. Wong
1
;
2
;
boyung@ust.hk" class="auth_mail" title="E-mail the corresponding author
关键词:
ELR
;
Glu-Leu-Arg
;
GPCRs
;
G protein-coupled receptors
;
NFκB
;
nuclear factor κB
;
STAT3
;
signal transducer and activator of transcription 3
;
MEM
;
minimum essential media
;
FLIPR
;
fluorometric imaging plate reader
刊名:Journal of Molecular Biology
出版年:2016
4.
Selective 5-HT
2C
receptor agonists: Design and synthesis of pyridazine-fused azepines
作者:
Martin P. Green
a
;
Gordon McMurray
b
;
R. Ian Storer
a
;
ian.storer@pfizer.com" class="auth_mail" title="E-mail the corresponding author
关键词:
ADME
;
absorption
;
distribution
;
metabolism
;
and excretion
;
CHO
;
Chinese hamster ovary
;
CNS
;
central nervous system
;
ER
;
efflux ratio
;
FLIPR
;
fluorescence imaging plate reader
;
HLM
;
human liver microsomes
;
MDCK
;
Madin&ndash
;
Darby Canine Kidney cell line
;
MDR-1
;
multidrug resistance gene 1
;
P-gp
;
P-glycoprotein transporter
;
RRCK
;
Ralph Russ Canine Kidney cell line
;
SPA
;
scintillation proximity assay
;
TFA
;
trifluoroacetic acid
刊名:Bioorganic & Medicinal Chemistry Letters
出版年:2016
5.
Systematic N-methylation of oxytocin: Impact on pharmacology and intramolecular hydrogen bonding network
作者:
Simone Sciabola
b
;
&dagger
;
;
Gilles H. Goetz
a
;
&dagger
;
;
Guoyun Bai
a
;
&dagger
;
;
Bruce N. Rogers
b
;
David L. Gray
b
;
Allen Duplantier
b
;
Kari R. Fonseca
c
;
Michelle A. Vanase-Frawley
a
;
Natasha M. Kablaoui
b
;
&dagger
;
;
Natasha.M.Kablaoui@pfizer.com" class="auth_mail" title="E-mail the corresponding author
关键词:
SFC
;
supercritical fluid chromatography
;
Mpa
;
mercaptopropionic acid
;
SPPS
;
solid phase peptide synthesis
;
FLIPR
;
fluorescent imaging plate reader
刊名:Bioorganic & Medicinal Chemistry
出版年:2016
6.
Synthesis and biology of ring-modified l-Histidine containing thyrotropin-releasing hormone (TRH) analogues
作者:
Chhuttan L. Meena
a
;
Avinash Thakur
b
;
Prajwal P. Nandekar
c
;
Shyam S. Sharma
b
;
Abhay T. Sangamwar
c
;
Rahul Jain
a
;
rahuljain@niper.ac.in" class="auth_mail" title="E-mail the corresponding author
关键词:
TRH
;
TRH analogues
;
Synthesis
;
TRH receptors
;
TSH
;
TRH-DE
;
Molecular modeling
刊名:European Journal of Medicinal Chemistry
出版年:2016
7.
Use of FDSS/μCell imaging platform for preclinical cardiac electrophysiology safety screening of compounds in human induced pluripotent stem cell-derived cardiomyocytes
作者:
Haoyu Zeng
;
haoyu.zeng@merck.com" class="auth_mail" title="E-mail the corresponding author
;
Maria I. Roman
;
Edward Lis
;
Armando Lagrutta
;
Frederick Sannajust
关键词:
hiPSC-CM
;
Preclinical cardiac safety
;
Ca2
;
+-transient
刊名:Journal of Pharmacological and Toxicological Methods
出版年:2016
8.
Hydroxycinnamic acid amides from Scopolia tangutica inhibit the activity of M1 muscarinic acetylcholine receptor in vitro
作者:
Yan Zhang
a
;
1
;
zhangyan_sjtu@sjtu.edu.cn" class="auth_mail" title="E-mail the corresponding author
;
Zhen Long
b
;
1
;
Zhimou Guo
b
;
Zhiwei Wang
c
;
Xiuli Zhang
b
;
Richard D. Ye
a
;
Xinmiao Liang
b
;
Olivier Civelli
c
关键词:
Scopolia tangutica Maxim
;
Hydroxycinnamic acid amides
;
M1 muscarinic acetylcholine receptor
刊名:Fitoterapia
出版年:2016
9.
Variability in high-throughput ion-channel screening data and consequences for cardiac safety assessment
作者:
Ryan C. Elkins
;
Mark R. Davies
;
Stephen J. Brough
;
David J. Gavaghan
;
Yi Cui
;
Najah Abi-Gerges
;
Gary R. Mirams
关键词:
AP(D)
;
Action Potential (Duration)
;
AZ
;
AstraZeneca
;
FLIPR
;
FLuorometric Imaging Plate Reader
;
GSK
;
GlaxoSmithKline
;
HTS
;
High Throughput Screening [assays]
;
IC50
;
Concentration for 50 % Inhibition
;
ICaL
;
L-type calcium current
;
IKr
;
rapid delayed rectifie
刊名:Journal of Pharmacological and Toxicological Methods
出版年:2013
10.
Biophysical and pharmacological characterization of 伪6-containing nicotinic acetylcholine receptors expressed in HEK293 cells
作者:
Andreas H. Rasmussen
;
Dorte Str酶b忙k
;
Tino Dyhring
;
Marianne L. Jensen
;
Dan Peters
;
Morten Grunnet
;
Daniel B. Timmermann
;
Philip K. Ahring
关键词:
ACh
;
Acetylcholine
;
nAChR
;
nicotinic acetylcholine receptor
;
伪6鈦?/sup>
;
伪6-containing
;
TM
;
transmembrane segment
刊名:Brain Research
出版年:13 January, 2014
1
2
3
4
5
6
7
8
9
按检索点细分(109)
题名(7)
关键词(54)
文摘(70)
按出版年细分(109)
2027年及以后(1)
2017年(2)
2016年(6)
2013年(9)
2012年(9)
2011年(1)
2010年(4)
2009年(3)
2008年(5)
2007年(2)
2006年(14)
2005年(7)
2004年(14)
2003年(10)
2002年(5)
2001年(8)
2000年(5)
2000年及以前(4)
NGLC 2004-2010.National Geological Library of China All Rights Reserved.
Add:29 Xueyuan Rd,Haidian District,Beijing,PRC. Mail Add: 8324 mailbox 100083
For exchange or info please contact us via
email
.