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CNKI学位论文(7)
知网期刊论文(49)
在“
Elsevier电子期刊
”中,
命中:
33
条,耗时:小于0.01 秒
在所有数据库中总计命中:
56
条
1.
Novel 5-nitropyrimidine derivatives bearing endo-azabicyclic alcohols/amines as potent
GPR119
agonists
关键词:
GPR119
agonists
;
5-Nitropyrimidine
;
endo-Azabicyclic alcohol
;
Full
agonists
刊名:Bioorganic & Medicinal Chemistry
出版年:2017
2.
Design and synthesis of 1H-pyrazolo[3,4-c]pyridine derivatives as a novel structural class of potent
GPR119
agonists
作者:
Daisuke Matsuda
a
;
;
Yohei Kobashi
a
;
Ayako Mikami
a
;
Madoka Kawamura
a
;
Fumiyasu Shiozawa
a
;
Kenichi Kawabe
a
;
Makoto Hamada
a
;
Koji Oda
a
;
Shinichi Nishimoto
b
;
Kayo Kimura
c
;
Masako Miyoshi
b
;
Noriko Takayama
b
;
Hiroyuki Kakinuma
a
;
Norikazu Ohtake
a
关键词:
Type 2 diabetes mellitus
;
GPR119
agonist
;
G-protein coupled receptor
;
Pyrazolopyridine
刊名:Bioorganic & Medicinal Chemistry Letters
出版年:2016
3.
Lipid derivatives activate
GPR119
and trigger GLP-1 secretion in primary murine L-cells
作者:
Catherine E. Moss
a
;
Leslie L. Glass
a
;
Eleftheria Diakogiannaki
a
;
Ramona Pais
a
;
Carol Lenaghan
b
;
David M. Smith
c
;
Marianne Wedin
d
;
Mohammad Bohlooly-Y
d
;
Fiona M. Gribble
a
;
fmg23@cam.ac.uk" class="auth_mail" title="E-mail the corresponding author
;
Frank Reimann
a
;
fr222@cam.ac.uk" class="auth_mail" title="E-mail the corresponding author
关键词:
2-OG
;
2-oleoylglycerol
;
Fsk
;
forskolin
;
GLP-1
;
glucagon-like peptide-1
;
IBMX
;
3-isobutyl-1-methylxanthine
;
KO
;
knockout
;
OEA
;
oleoylethanolamide
;
PPAR
;
peroxisome-proliferator-activated receptor
;
WT
;
wildtype
刊名:Peptides
出版年:2016
4.
Biased signaling of lipids and allosteric actions of synthetic molecules for
GPR119
作者:
Helle A. Hassing
a
;
b
;
Suzan Fares
a
;
Olav Larsen
a
;
Hamideh Pad
a
;
b
;
Maria Hauge
a
;
c
;
Robert M. Jones
d
;
Thue W. Schwartz
a
;
c
;
Harald S. Hansen
b
;
hsh@sund.ku.dk" class="auth_mail" title="E-mail the corresponding author
;
Mette M. Rosenkilde
a
;
rosenkilde@sund.ku.dk" class="auth_mail" title="E-mail the corresponding author
关键词:
CREB
;
cAMP response element-binding protein
;
EEC
;
enteroendocrine cell
;
FAAH
;
fatty acid amide hydrolase
;
FBS
;
Fetal Bovine Serum
;
GIP
;
glucose-dependent insulinotropic polypeptide
;
GLP-1
;
glucagon-like-peptide 1
;
GPCR
;
G protein-coupled receptor
;
LPC
;
lysophosphatidylcholine
;
MAG
;
monoacylglycerol
;
MAGL
;
monoacylglycerol lipase
;
MEM
;
minimal essential medium
;
NAE
;
N-acylethanolamine
;
OEA
;
oleoylethanolamide
;
OLDA
;
N-oleoyldopamine
;
SRE
;
serum response element
;
7TM
;
seven transmembrane receptor
刊名:Biochemical Pharmacology
出版年:2016
5.
Discovery of the oxazabicyclo[3.3.1]nonane derivatives as potent and orally active
GPR119
agonists
作者:
Xing Dai
a
;
;
Andrew Stamford
a
;
Hong Liu
a
;
Bernard Neustadt
a
;
Jingsong Hao
a
;
Tim Kowalski
b
;
Brian Hawes
b
;
Xiaoying Xu
c
;
Hana Baker
b
;
Kim O&rsquo
;
Neill
b
;
Morgan Woods
b
;
Huadong Tang
c
;
William Greenlee
a
关键词:
GPR119
agonist
;
Type 2 diabetes
;
Bridged piperidine
;
Glucose-dependent insulin secretion
刊名:Bioorganic & Medicinal Chemistry Letters
出版年:2015
6.
Discovery and optimization of 5-(2-((1-(phenylsulfonyl)-1,2,3,4-tetrahydroquinolin-7-yl)oxy)pyridin-4-yl)-1,2,4-oxadiazoles as novel
gpr119
agonists
作者:
Yingcai Wang
;
Ming Yu
;
Jiang Zhu
;
Jian (Ken) Zhang
;
Frank Kayser
;
Julio C. Medina
;
Karen Siegler
;
Marion Conn
;
Bei Shan
;
Mark P. Grillo
;
Jiwen (Jim) Liu
;
Peter Coward
关键词:
GPR119
;
Agonists
;
Oxadiazole
;
Constrain
;
Free fraction
刊名:Bioorganic and Medicinal Chemistry Letters
出版年:15 February, 2014
7.
Discovery of structurally novel, potent and orally efficacious
GPR119
agonists
作者:
Phil Alper
;
palper@gnf.org" class="auth_mail
;
Mihai Azimioara
;
Christopher Cow
;
Daniel Mutnick
;
Victor Nikulin
;
Pierre-Yves Michellys
;
Zhiliang Wang
;
Esther Reding
;
Michael Paliotti
;
Jing Li
;
Dingjiu Bao
;
Jocelyn Zoll
;
Young Kim
;
Matthew Zimmerman
;
Todd Groessel
;
Tove Tuntland
;
Sean B. Joseph
;
Peter McNamara
;
H. Martin Seidel
;
Robert Epple
;
repple@gnf.org" class="auth_mail
关键词:
GPCR
agonists
;
GPR119
;
Pyrazolopyrimidines
;
Type 2 diabetes
刊名:Bioorganic and Medicinal Chemistry Letters
出版年:15 May 2014
8.
Synthesis and structure-activity relationship of dihydrobenzofuran derivatives as novel human
GPR119
agonists
作者:
Xiang-Yang Ye
a
;
xiang-yang.ye@bms.com" class="auth_mail
;
Christian L. Morales
a
;
Ying Wang
a
;
Karen A. Rossi
b
;
Sarah E. Malmstrom
c
;
Mojgan Abousleiman
c
;
Larisa Sereda
e
;
Atsu Apedo
d
;
Jeffrey A. Robl
a
;
Keith J. Miller
e
;
John Krupinski
e
;
Dean A. Wacker
a
关键词:
GPR119
;
Agonist
;
Type 2 diabetes
刊名:Bioorganic and Medicinal Chemistry Letters
出版年:1 June 2014
9.
Discovery of pyrazolo[3,4-d]pyrimidine derivatives as
GPR119
agonists
作者:
Paul Gillespie
;
Robert A. Goodnow Jr.
;
Goutam Saha
;
Gopal Bose
;
Kakali Moulik
;
Catherine Zwingelstein
;
Michael Myers
;
Karin Conde-Knape
;
Sherrie Pietranico-Cole
;
Sung-Sau So
关键词:
GPR119
;
GPCR
;
Agonist
;
Type 2 diabetes
;
Oral glucose tolerance test
刊名:Bioorganic and Medicinal Chemistry Letters
出版年:1 February, 2014
10.
Discovery and optimization of N-(3-(1,3-dioxo-2,3-dihydro-1H-pyrrolo[3,4-c]pyridin-4-yloxy)phenyl)benzenesulfonamides as novel
GPR119
agonists
作者:
Ming Yu
;
Jian (Ken) Zhang
;
Yingcai Wang
;
Jiang Zhu
;
Frank Kayser
;
Julio C. Medina
;
Karen Siegler
;
Marion Conn
;
Bei Shan
;
Mark P. Grillo
;
Peter Coward
;
Jiwen (Jim) Liu
关键词:
GPR119
;
Agonist
;
Type 2 diabetes
刊名:Bioorganic and Medicinal Chemistry Letters
出版年:1 January, 2014
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